Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CLEC7A (C-type lectin domain containing 7A)

Identity

Alias_namesCLECSF12
C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12
C-type lectin domain family 7, member A
Alias_symbol (synonym)dectin-1
hDectin-1
CD369
SCARE2
Other aliasBGR
CANDF4
DECTIN1
HGNC (Hugo) CLEC7A
LocusID (NCBI) 64581
Atlas_Id 50429
Location 12p13.2  [Link to chromosome band 12p13]
Location_base_pair Starts at 10116781 and ends at 10130269 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CLEC7A   14558
LRG (Locus Reference Genomic)LRG_179
Cards
Entrez_Gene (NCBI)CLEC7A  64581  C-type lectin domain containing 7A
AliasesBGR; CANDF4; CD369; CLECSF12; 
DECTIN1; SCARE2
GeneCards (Weizmann)CLEC7A
Ensembl hg19 (Hinxton)ENSG00000172243 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000172243 [Gene_View]  chr12:10116781-10130269 [Contig_View]  CLEC7A [Vega]
ICGC DataPortalENSG00000172243
TCGA cBioPortalCLEC7A
AceView (NCBI)CLEC7A
Genatlas (Paris)CLEC7A
WikiGenes64581
SOURCE (Princeton)CLEC7A
Genetics Home Reference (NIH)CLEC7A
Genomic and cartography
GoldenPath hg38 (UCSC)CLEC7A  -     chr12:10116781-10130269 -  12p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CLEC7A  -     12p13.2   [Description]    (hg19-Feb_2009)
EnsemblCLEC7A - 12p13.2 [CytoView hg19]  CLEC7A - 12p13.2 [CytoView hg38]
Mapping of homologs : NCBICLEC7A [Mapview hg19]  CLEC7A [Mapview hg38]
OMIM606264   613108   614079   
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)NM_022570 NM_197947 NM_197948 NM_197949 NM_197950 NM_197951 NM_197952 NM_197953 NM_197954
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CLEC7A
Cluster EST : UnigeneHs.143929 [ NCBI ]
CGAP (NCI)Hs.143929
Alternative Splicing GalleryENSG00000172243
Gene ExpressionCLEC7A [ NCBI-GEO ]   CLEC7A [ EBI - ARRAY_EXPRESS ]   CLEC7A [ SEEK ]   CLEC7A [ MEM ]
Gene Expression Viewer (FireBrowse)CLEC7A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64581
GTEX Portal (Tissue expression)CLEC7A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BXN2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BXN2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BXN2
Splice isoforms : SwissVarQ9BXN2
PhosPhoSitePlusQ9BXN2
Domaine pattern : Prosite (Expaxy)C_TYPE_LECTIN_2 (PS50041)   
Domains : Interpro (EBI)C-type_lectin-like    C-type_lectin-like/link    CTDL_fold    NKR-like_CTLD   
Domain families : Pfam (Sanger)Lectin_C (PF00059)   
Domain families : Pfam (NCBI)pfam00059   
Domain families : Smart (EMBL)CLECT (SM00034)  
Conserved Domain (NCBI)CLEC7A
DMDM Disease mutations64581
Blocks (Seattle)CLEC7A
SuperfamilyQ9BXN2
Human Protein AtlasENSG00000172243
Peptide AtlasQ9BXN2
HPRD08396
IPIIPI00411381   IPI00021735   IPI00155858   IPI00186897   IPI00044332   IPI00815987   IPI00170475   IPI00044331   IPI00432359   IPI00060623   IPI00044329   IPI00470855   
Protein Interaction databases
DIP (DOE-UCLA)Q9BXN2
IntAct (EBI)Q9BXN2
FunCoupENSG00000172243
BioGRIDCLEC7A
STRING (EMBL)CLEC7A
ZODIACCLEC7A
Ontologies - Pathways
QuickGOQ9BXN2
Ontology : AmiGOpattern recognition receptor signaling pathway  stimulatory C-type lectin receptor signaling pathway  leukocyte activation involved in immune response  protein binding  nucleoplasm  cytoplasm  plasma membrane  phagocytosis, recognition  inflammatory response  cell recognition  signaling pattern recognition receptor activity  carbohydrate mediated signaling  integral component of membrane  carbohydrate binding  T cell activation  MHC protein binding  defense response to protozoan  intracellular membrane-bounded organelle  innate immune response  metal ion binding  cellular response to molecule of fungal origin  
Ontology : EGO-EBIpattern recognition receptor signaling pathway  stimulatory C-type lectin receptor signaling pathway  leukocyte activation involved in immune response  protein binding  nucleoplasm  cytoplasm  plasma membrane  phagocytosis, recognition  inflammatory response  cell recognition  signaling pattern recognition receptor activity  carbohydrate mediated signaling  integral component of membrane  carbohydrate binding  T cell activation  MHC protein binding  defense response to protozoan  intracellular membrane-bounded organelle  innate immune response  metal ion binding  cellular response to molecule of fungal origin  
Pathways : KEGGPhagosome    Tuberculosis   
NDEx NetworkCLEC7A
Atlas of Cancer Signalling NetworkCLEC7A
Wikipedia pathwaysCLEC7A
Orthology - Evolution
OrthoDB64581
GeneTree (enSembl)ENSG00000172243
Phylogenetic Trees/Animal Genes : TreeFamCLEC7A
HOVERGENQ9BXN2
HOGENOMQ9BXN2
Homologs : HomoloGeneCLEC7A
Homology/Alignments : Family Browser (UCSC)CLEC7A
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCLEC7A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CLEC7A
dbVarCLEC7A
ClinVarCLEC7A
1000_GenomesCLEC7A 
Exome Variant ServerCLEC7A
ExAC (Exome Aggregation Consortium)CLEC7A (select the gene name)
Genetic variants : HAPMAP64581
Genomic Variants (DGV)CLEC7A [DGVbeta]
DECIPHERCLEC7A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCLEC7A 
Mutations
ICGC Data PortalCLEC7A 
TCGA Data PortalCLEC7A 
Broad Tumor PortalCLEC7A
OASIS PortalCLEC7A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCLEC7A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCLEC7A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch CLEC7A
DgiDB (Drug Gene Interaction Database)CLEC7A
DoCM (Curated mutations)CLEC7A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CLEC7A (select a term)
intoGenCLEC7A
Cancer3DCLEC7A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606264    613108    614079   
Orphanet432   
MedgenCLEC7A
Genetic Testing Registry CLEC7A
NextProtQ9BXN2 [Medical]
TSGene64581
GENETestsCLEC7A
Target ValidationCLEC7A
Huge Navigator CLEC7A [HugePedia]
snp3D : Map Gene to Disease64581
BioCentury BCIQCLEC7A
ClinGenCLEC7A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64581
Chemical/Pharm GKB GenePA26581
Clinical trialCLEC7A
Miscellaneous
canSAR (ICR)CLEC7A (select the gene name)
Probes
Litterature
PubMed100 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCLEC7A
EVEXCLEC7A
GoPubMedCLEC7A
iHOPCLEC7A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:28:42 CEST 2017

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