CLEC7A (C-type lectin domain containing 7A)

2008-10-01  

Identity

HGNC
LOCATION
12p13.2
LOCUSID
ALIAS
BGR,CANDF4,CD369,CLECSF12,DECTIN1,SCARE2

Other Information

Locus ID:

NCBI: 64581
MIM: 606264
HGNC: 14558
Ensembl: ENSG00000172243

Variants:

dbSNP: 64581
ClinVar: 64581
TCGA: ENSG00000172243
COSMIC: CLEC7A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172243ENST00000298523Q9BXN2
ENSG00000172243ENST00000304084Q9BXN2
ENSG00000172243ENST00000304084A0A024RAN9
ENSG00000172243ENST00000310002Q9BXN2
ENSG00000172243ENST00000310002A0A0S2Z5Q1
ENSG00000172243ENST00000349926Q9BXN2
ENSG00000172243ENST00000353231Q9BXN2
ENSG00000172243ENST00000396484Q9BXN2
ENSG00000172243ENST00000465100Q9BXN2
ENSG00000172243ENST00000525605Q68D78
ENSG00000172243ENST00000529761Q9BXN2
ENSG00000172243ENST00000529761A0A024RAN9
ENSG00000172243ENST00000531192Q9BXN2
ENSG00000172243ENST00000533022Q9BXN2

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
C-type lectin receptors (CLRs)REACTOMER-HSA-5621481
CLEC7A (Dectin-1) signalingREACTOMER-HSA-5607764

References

Pubmed IDYearTitleCitations
226743282012Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis.318
198646742009Human dectin-1 deficiency and mucocutaneous fungal infections.254
222672172012Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome.201
159562832005Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production.167
191226532009Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk.154
185494572008Dectin-1 synergizes with TLR2 and TLR4 for cytokine production in human primary monocytes and macrophages.99
208078862010Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity.99
208078862010Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity.99
192231622009Pattern recognition: recent insights from Dectin-1.97
204216392010(1,3)-beta-glucans activate both dectin-1 and NLRP3 inflammasome in human macrophages.87

Citation

Dessen P

CLEC7A (C-type lectin domain containing 7A)

Atlas Genet Cytogenet Oncol Haematol. 2008-10-01

Online version: http://atlasgeneticsoncology.org/gene/50429/clec7a