CLEC9A (C-type lectin domain containing 9A)

2016-04-01 Affiliation

Identity

HGNC

CLEC9A

LOCATION

12p13.2

LOCUSID

283420

ALIAS

CD370,DNGR-1,DNGR1,UNQ9341

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 283420
MIM: 612252
HGNC: 26705
Ensembl: ENSG00000197992

Variants:

dbSNP: 283420
ClinVar: 283420
TCGA: ENSG00000197992
COSMIC: CLEC9A

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000197992	ENST00000355819	Q6UXN8

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

References

Pubmed ID	Year	Title	Citations
20479117	2010	Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cells.	267
21677141	2011	Targeting antigen to mouse dendritic cells via Clec9A induces potent CD4 T cell responses biased toward a follicular helper phenotype.	66
24910448	2015	BDCA3(+)CLEC9A(+) human dendritic cell function and development.	20
24049150	2013	Increased tubulointerstitial recruitment of human CD141(hi) CLEC9A(+) and CD1c(+) myeloid dendritic cell subsets in renal fibrosis and chronic kidney disease.	19
18408006	2008	CLEC9A is a novel activation C-type lectin-like receptor expressed on BDCA3+ dendritic cells and a subset of monocytes.	0
18497879	2008	Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin.	0
18497879	2008	Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin.	0
18669894	2008	The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement.	0
19219027	2009	Identification of a dendritic cell receptor that couples sensing of necrosis to immunity.	0
22234694	2012	The C-type lectin receptor CLEC9A mediates antigen uptake and (cross-)presentation by human blood BDCA3+ myeloid dendritic cells.	0

Citation

Dessen P

CLEC9A (C-type lectin domain containing 9A)

Atlas Genet Cytogenet Oncol Haematol. 2016-04-01

Online version: http://atlasgeneticsoncology.org/gene/55695/clec9a