Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CLIC2 (chloride intracellular channel 2)

Identity

Alias_symbol (synonym)XAP121
Other aliasCLIC2b
MRXS32
HGNC (Hugo) CLIC2
LocusID (NCBI) 1193
Atlas_Id 61884
Location Xq28  [Link to chromosome band Xq28]
Location_base_pair Starts at 155276207 and ends at 155334681 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CLIC2 (Xq28) / VPS39 (15q15.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CLIC2   2063
Cards
Entrez_Gene (NCBI)CLIC2  1193  chloride intracellular channel 2
AliasesCLIC2b; MRXS32; XAP121
GeneCards (Weizmann)CLIC2
Ensembl hg19 (Hinxton)ENSG00000155962 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000155962 [Gene_View]  chrX:155276207-155334681 [Contig_View]  CLIC2 [Vega]
ICGC DataPortalENSG00000155962
TCGA cBioPortalCLIC2
AceView (NCBI)CLIC2
Genatlas (Paris)CLIC2
WikiGenes1193
SOURCE (Princeton)CLIC2
Genetics Home Reference (NIH)CLIC2
Genomic and cartography
GoldenPath hg38 (UCSC)CLIC2  -     chrX:155276207-155334681 -  Xq28   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CLIC2  -     Xq28   [Description]    (hg19-Feb_2009)
EnsemblCLIC2 - Xq28 [CytoView hg19]  CLIC2 - Xq28 [CytoView hg38]
Mapping of homologs : NCBICLIC2 [Mapview hg19]  CLIC2 [Mapview hg38]
OMIM300138   300886   
Gene and transcription
Genbank (Entrez)AK292785 AM393055 AW961768 AY191592 BC005367
RefSeq transcript (Entrez)NM_001289
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CLIC2
Cluster EST : UnigeneHs.655445 [ NCBI ]
CGAP (NCI)Hs.655445
Alternative Splicing GalleryENSG00000155962
Gene ExpressionCLIC2 [ NCBI-GEO ]   CLIC2 [ EBI - ARRAY_EXPRESS ]   CLIC2 [ SEEK ]   CLIC2 [ MEM ]
Gene Expression Viewer (FireBrowse)CLIC2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1193
GTEX Portal (Tissue expression)CLIC2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15247   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15247  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15247
Splice isoforms : SwissVarO15247
PhosPhoSitePlusO15247
Domaine pattern : Prosite (Expaxy)GST_CTER (PS50405)   
Domains : Interpro (EBI)CLIC    CLIC-2    Glutathione-S-Trfase_C-like    Glutathione_S-Trfase_N    Thioredoxin-like_fold   
Domain families : Pfam (Sanger)GST_N_2 (PF13409)   
Domain families : Pfam (NCBI)pfam13409   
Conserved Domain (NCBI)CLIC2
DMDM Disease mutations1193
Blocks (Seattle)CLIC2
PDB (SRS)2PER    2R4V    2R5G   
PDB (PDBSum)2PER    2R4V    2R5G   
PDB (IMB)2PER    2R4V    2R5G   
PDB (RSDB)2PER    2R4V    2R5G   
Structural Biology KnowledgeBase2PER    2R4V    2R5G   
SCOP (Structural Classification of Proteins)2PER    2R4V    2R5G   
CATH (Classification of proteins structures)2PER    2R4V    2R5G   
SuperfamilyO15247
Human Protein AtlasENSG00000155962
Peptide AtlasO15247
HPRD02139
IPIIPI00221328   IPI00853014   IPI00384724   
Protein Interaction databases
DIP (DOE-UCLA)O15247
IntAct (EBI)O15247
FunCoupENSG00000155962
BioGRIDCLIC2
STRING (EMBL)CLIC2
ZODIACCLIC2
Ontologies - Pathways
QuickGOO15247
Ontology : AmiGOglutathione transferase activity  glutathione peroxidase activity  voltage-gated ion channel activity  chloride channel activity  protein binding  intracellular  nucleus  cytoplasm  cytoplasm  transport  signal transduction  regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  chloride channel complex  positive regulation of binding  negative regulation of ryanodine-sensitive calcium-release channel activity  cellular oxidant detoxification  chloride transmembrane transport  
Ontology : EGO-EBIglutathione transferase activity  glutathione peroxidase activity  voltage-gated ion channel activity  chloride channel activity  protein binding  intracellular  nucleus  cytoplasm  cytoplasm  transport  signal transduction  regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  chloride channel complex  positive regulation of binding  negative regulation of ryanodine-sensitive calcium-release channel activity  cellular oxidant detoxification  chloride transmembrane transport  
NDEx NetworkCLIC2
Atlas of Cancer Signalling NetworkCLIC2
Wikipedia pathwaysCLIC2
Orthology - Evolution
OrthoDB1193
GeneTree (enSembl)ENSG00000155962
Phylogenetic Trees/Animal Genes : TreeFamCLIC2
HOVERGENO15247
HOGENOMO15247
Homologs : HomoloGeneCLIC2
Homology/Alignments : Family Browser (UCSC)CLIC2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCLIC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CLIC2
dbVarCLIC2
ClinVarCLIC2
1000_GenomesCLIC2 
Exome Variant ServerCLIC2
ExAC (Exome Aggregation Consortium)CLIC2 (select the gene name)
Genetic variants : HAPMAP1193
Genomic Variants (DGV)CLIC2 [DGVbeta]
DECIPHERCLIC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCLIC2 
Mutations
ICGC Data PortalCLIC2 
TCGA Data PortalCLIC2 
Broad Tumor PortalCLIC2
OASIS PortalCLIC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCLIC2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCLIC2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch CLIC2
DgiDB (Drug Gene Interaction Database)CLIC2
DoCM (Curated mutations)CLIC2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CLIC2 (select a term)
intoGenCLIC2
Cancer3DCLIC2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300138    300886   
Orphanet21774   
MedgenCLIC2
Genetic Testing Registry CLIC2
NextProtO15247 [Medical]
TSGene1193
GENETestsCLIC2
Target ValidationCLIC2
Huge Navigator CLIC2 [HugePedia]
snp3D : Map Gene to Disease1193
BioCentury BCIQCLIC2
ClinGenCLIC2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1193
Chemical/Pharm GKB GenePA26589
Clinical trialCLIC2
Miscellaneous
canSAR (ICR)CLIC2 (select the gene name)
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCLIC2
EVEXCLIC2
GoPubMedCLIC2
iHOPCLIC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:04:57 CEST 2017

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