Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

CLIC5 (chloride intracellular channel 5)

Identity

Alias_symbol (synonym)DFNB102
Other aliasDFNB103
MST130
MSTP130
HGNC (Hugo) CLIC5
LocusID (NCBI) 53405
Atlas_Id 55730
Location 6p21.1  [Link to chromosome band 6p21]
Location_base_pair Starts at 45898453 and ends at 46015889 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CLIC5 (6p21.1) / CLIC5 (6p21.1)CLIC5 (6p21.1) / SUPT3H (6p21.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;6)(p21;p21) CLIC5/SUPT3H


External links

Nomenclature
HGNC (Hugo)CLIC5   13517
Cards
Entrez_Gene (NCBI)CLIC5  53405  chloride intracellular channel 5
AliasesDFNB102; DFNB103; MST130; MSTP130
GeneCards (Weizmann)CLIC5
Ensembl hg19 (Hinxton)ENSG00000112782 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112782 [Gene_View]  ENSG00000112782 [Sequence]  chr6:45898453-46015889 [Contig_View]  CLIC5 [Vega]
ICGC DataPortalENSG00000112782
TCGA cBioPortalCLIC5
AceView (NCBI)CLIC5
Genatlas (Paris)CLIC5
WikiGenes53405
SOURCE (Princeton)CLIC5
Genetics Home Reference (NIH)CLIC5
Genomic and cartography
GoldenPath hg38 (UCSC)CLIC5  -     chr6:45898453-46015889 -  6p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CLIC5  -     6p21.1   [Description]    (hg19-Feb_2009)
EnsemblCLIC5 - 6p21.1 [CytoView hg19]  CLIC5 - 6p21.1 [CytoView hg38]
Mapping of homologs : NCBICLIC5 [Mapview hg19]  CLIC5 [Mapview hg38]
OMIM607293   616042   
Gene and transcription
Genbank (Entrez)AF086005 AF176920 AF216941 AJ420547 AK025350
RefSeq transcript (Entrez)NM_001114086 NM_001256023 NM_016929
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CLIC5
Cluster EST : UnigeneHs.734348 [ NCBI ]
CGAP (NCI)Hs.734348
Alternative Splicing GalleryENSG00000112782
Gene ExpressionCLIC5 [ NCBI-GEO ]   CLIC5 [ EBI - ARRAY_EXPRESS ]   CLIC5 [ SEEK ]   CLIC5 [ MEM ]
Gene Expression Viewer (FireBrowse)CLIC5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)53405
GTEX Portal (Tissue expression)CLIC5
Human Protein AtlasENSG00000112782-CLIC5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NZA1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NZA1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NZA1
Splice isoforms : SwissVarQ9NZA1
PhosPhoSitePlusQ9NZA1
Domaine pattern : Prosite (Expaxy)GST_CTER (PS50405)   
Domains : Interpro (EBI)CLIC    CLIC-5    Glutathione-S-Trfase_C-like    Glutathione-S-Trfase_C_sf    Glutathione_S-Trfase_N    Thioredoxin-like_sf   
Domain families : Pfam (Sanger)GST_N_3 (PF13417)   
Domain families : Pfam (NCBI)pfam13417   
Conserved Domain (NCBI)CLIC5
DMDM Disease mutations53405
Blocks (Seattle)CLIC5
SuperfamilyQ9NZA1
Human Protein Atlas [tissue]ENSG00000112782-CLIC5 [tissue]
Peptide AtlasQ9NZA1
HPRD06292
IPIIPI00027193   IPI00294443   IPI00166951   IPI00844301   
Protein Interaction databases
DIP (DOE-UCLA)Q9NZA1
IntAct (EBI)Q9NZA1
FunCoupENSG00000112782
BioGRIDCLIC5
STRING (EMBL)CLIC5
ZODIACCLIC5
Ontologies - Pathways
QuickGOQ9NZA1
Ontology : AmiGOvoltage-gated ion channel activity  chloride channel activity  protein binding  Golgi apparatus  microtubule organizing center  cell cortex  chloride transport  female pregnancy  sensory perception of sound  actin cytoskeleton  chloride channel complex  regulation of ion transmembrane transport  extracellular exosome  chloride transmembrane transport  
Ontology : EGO-EBIvoltage-gated ion channel activity  chloride channel activity  protein binding  Golgi apparatus  microtubule organizing center  cell cortex  chloride transport  female pregnancy  sensory perception of sound  actin cytoskeleton  chloride channel complex  regulation of ion transmembrane transport  extracellular exosome  chloride transmembrane transport  
NDEx NetworkCLIC5
Atlas of Cancer Signalling NetworkCLIC5
Wikipedia pathwaysCLIC5
Orthology - Evolution
OrthoDB53405
GeneTree (enSembl)ENSG00000112782
Phylogenetic Trees/Animal Genes : TreeFamCLIC5
HOVERGENQ9NZA1
HOGENOMQ9NZA1
Homologs : HomoloGeneCLIC5
Homology/Alignments : Family Browser (UCSC)CLIC5
Gene fusions - Rearrangements
Fusion : QuiverCLIC5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCLIC5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CLIC5
dbVarCLIC5
ClinVarCLIC5
1000_GenomesCLIC5 
Exome Variant ServerCLIC5
ExAC (Exome Aggregation Consortium)ENSG00000112782
GNOMAD BrowserENSG00000112782
Varsome BrowserCLIC5
Genetic variants : HAPMAP53405
Genomic Variants (DGV)CLIC5 [DGVbeta]
DECIPHERCLIC5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCLIC5 
Mutations
ICGC Data PortalCLIC5 
TCGA Data PortalCLIC5 
Broad Tumor PortalCLIC5
OASIS PortalCLIC5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCLIC5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCLIC5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CLIC5
DgiDB (Drug Gene Interaction Database)CLIC5
DoCM (Curated mutations)CLIC5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CLIC5 (select a term)
intoGenCLIC5
Cancer3DCLIC5(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607293    616042   
Orphanet12047   
DisGeNETCLIC5
MedgenCLIC5
Genetic Testing Registry CLIC5
NextProtQ9NZA1 [Medical]
TSGene53405
GENETestsCLIC5
Target ValidationCLIC5
Huge Navigator CLIC5 [HugePedia]
snp3D : Map Gene to Disease53405
BioCentury BCIQCLIC5
ClinGenCLIC5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD53405
Chemical/Pharm GKB GenePA26592
Clinical trialCLIC5
Miscellaneous
canSAR (ICR)CLIC5 (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCLIC5
EVEXCLIC5
GoPubMedCLIC5
iHOPCLIC5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 10:58:48 CET 2018

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.