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CLIP1 (CAP-Gly domain containing linker protein 1)

Identity

Alias_namesRSN
restin (Reed-Steinberg cell-expressed intermediate filament-associated protein)
CAP-GLY domain containing linker protein 1
Alias_symbol (synonym)CYLN1
CLIP170
CLIP
CLIP-170
Other alias
HGNC (Hugo) CLIP1
LocusID (NCBI) 6249
Atlas_Id 42178
Location 12q24.31  [Link to chromosome band 12q24]
Location_base_pair Starts at 122271434 and ends at 122422569 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ADAM12 (10q26.2) / CLIP1 (12q24.31)CCDC58 (3q21.1) / CLIP1 (12q24.31)CLIP1 (12q24.31) / APEX1 (14q11.2)
CLIP1 (12q24.31) / CLIP1 (12q24.31)CLIP1 (12q24.31) / DPP9 (19p13.3)CLIP1 (12q24.31) / RILPL2 (12q24.31)
CLIP1 (12q24.31) / ROS1 (6q22.1)CLIP1 (12q24.31) / SLC8B1 (12q24.13)CLIP1 (12q24.31) / SLFN12L (17q12)
CLIP1 (12q24.31) / SPIN3 (Xp11.21)CLIP1 (12q24.31) / TMEM161B (5q14.3)LIPA (10q23.31) / CLIP1 (12q24.31)
RABGAP1L (1q25.1) / CLIP1 (12q24.31)CLIP1 12q24.31 / ROS1 6q22.1CLIP1 12q24.31 SLC24A6

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CLIP1   10461
Cards
Entrez_Gene (NCBI)CLIP1  6249  CAP-Gly domain containing linker protein 1
AliasesCLIP; CLIP-170; CLIP170; CYLN1; 
RSN
GeneCards (Weizmann)CLIP1
Ensembl hg19 (Hinxton)ENSG00000130779 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000130779 [Gene_View]  chr12:122271434-122422569 [Contig_View]  CLIP1 [Vega]
ICGC DataPortalENSG00000130779
TCGA cBioPortalCLIP1
AceView (NCBI)CLIP1
Genatlas (Paris)CLIP1
WikiGenes6249
SOURCE (Princeton)CLIP1
Genetics Home Reference (NIH)CLIP1
Genomic and cartography
GoldenPath hg38 (UCSC)CLIP1  -     chr12:122271434-122422569 -  12q24.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CLIP1  -     12q24.31   [Description]    (hg19-Feb_2009)
EnsemblCLIP1 - 12q24.31 [CytoView hg19]  CLIP1 - 12q24.31 [CytoView hg38]
Mapping of homologs : NCBICLIP1 [Mapview hg19]  CLIP1 [Mapview hg38]
OMIM179838   
Gene and transcription
Genbank (Entrez)AB209115 AF045652 AF045653 AK123769 AK126990
RefSeq transcript (Entrez)NM_001247997 NM_002956 NM_198240
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CLIP1
Cluster EST : UnigeneHs.524809 [ NCBI ]
CGAP (NCI)Hs.524809
Alternative Splicing GalleryENSG00000130779
Gene ExpressionCLIP1 [ NCBI-GEO ]   CLIP1 [ EBI - ARRAY_EXPRESS ]   CLIP1 [ SEEK ]   CLIP1 [ MEM ]
Gene Expression Viewer (FireBrowse)CLIP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6249
GTEX Portal (Tissue expression)CLIP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP30622   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP30622  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP30622
Splice isoforms : SwissVarP30622
PhosPhoSitePlusP30622
Domaine pattern : Prosite (Expaxy)CAP_GLY_1 (PS00845)    CAP_GLY_2 (PS50245)   
Domains : Interpro (EBI)CAP-Gly_domain    CLIP1_ZNF   
Domain families : Pfam (Sanger)CAP_GLY (PF01302)    CLIP1_ZNF (PF16641)   
Domain families : Pfam (NCBI)pfam01302    pfam16641   
Domain families : Smart (EMBL)CAP_GLY (SM01052)  
Conserved Domain (NCBI)CLIP1
DMDM Disease mutations6249
Blocks (Seattle)CLIP1
PDB (SRS)2CP5    2CP6    2E3H    2E3I    2E4H    2HQH    2QK0    3E2U    3RDV   
PDB (PDBSum)2CP5    2CP6    2E3H    2E3I    2E4H    2HQH    2QK0    3E2U    3RDV   
PDB (IMB)2CP5    2CP6    2E3H    2E3I    2E4H    2HQH    2QK0    3E2U    3RDV   
PDB (RSDB)2CP5    2CP6    2E3H    2E3I    2E4H    2HQH    2QK0    3E2U    3RDV   
Structural Biology KnowledgeBase2CP5    2CP6    2E3H    2E3I    2E4H    2HQH    2QK0    3E2U    3RDV   
SCOP (Structural Classification of Proteins)2CP5    2CP6    2E3H    2E3I    2E4H    2HQH    2QK0    3E2U    3RDV   
CATH (Classification of proteins structures)2CP5    2CP6    2E3H    2E3I    2E4H    2HQH    2QK0    3E2U    3RDV   
SuperfamilyP30622
Human Protein AtlasENSG00000130779
Peptide AtlasP30622
HPRD01568
IPIIPI00027172   IPI00217113   IPI00013455   IPI01013516   IPI00747225   IPI01013425   IPI00384485   IPI00873870   IPI01012520   IPI00788776   IPI01010481   IPI01010166   
Protein Interaction databases
DIP (DOE-UCLA)P30622
IntAct (EBI)P30622
FunCoupENSG00000130779
BioGRIDCLIP1
STRING (EMBL)CLIP1
ZODIACCLIP1
Ontologies - Pathways
QuickGOP30622
Ontology : AmiGOmitotic cell cycle  kinetochore  microtubule bundle formation  ruffle  protein binding  nuclear envelope  endosome  centrosome  cytosol  microtubule  microtubule  cytoplasmic microtubule  intermediate filament  sister chromatid cohesion  microtubule binding  zinc ion binding  microtubule cytoskeleton  tubulin binding  cytoplasmic vesicle membrane  positive regulation of microtubule polymerization  microtubule plus-end  protein homodimerization activity  macropinosome  protein transport into plasma membrane raft  metal ion binding  microtubule plus-end binding  
Ontology : EGO-EBImitotic cell cycle  kinetochore  microtubule bundle formation  ruffle  protein binding  nuclear envelope  endosome  centrosome  cytosol  microtubule  microtubule  cytoplasmic microtubule  intermediate filament  sister chromatid cohesion  microtubule binding  zinc ion binding  microtubule cytoskeleton  tubulin binding  cytoplasmic vesicle membrane  positive regulation of microtubule polymerization  microtubule plus-end  protein homodimerization activity  macropinosome  protein transport into plasma membrane raft  metal ion binding  microtubule plus-end binding  
Pathways : BIOCARTALissencephaly gene (LIS1) in neuronal migration and development [Genes]   
NDEx NetworkCLIP1
Atlas of Cancer Signalling NetworkCLIP1
Wikipedia pathwaysCLIP1
Orthology - Evolution
OrthoDB6249
GeneTree (enSembl)ENSG00000130779
Phylogenetic Trees/Animal Genes : TreeFamCLIP1
HOVERGENP30622
HOGENOMP30622
Homologs : HomoloGeneCLIP1
Homology/Alignments : Family Browser (UCSC)CLIP1
Gene fusions - Rearrangements
Fusion : MitelmanCLIP1/SLC8B1 [12q24.31/12q24.13]  
Fusion: TCGACLIP1 12q24.31 SLC24A6 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCLIP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CLIP1
dbVarCLIP1
ClinVarCLIP1
1000_GenomesCLIP1 
Exome Variant ServerCLIP1
ExAC (Exome Aggregation Consortium)CLIP1 (select the gene name)
Genetic variants : HAPMAP6249
Genomic Variants (DGV)CLIP1 [DGVbeta]
DECIPHERCLIP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCLIP1 
Mutations
ICGC Data PortalCLIP1 
TCGA Data PortalCLIP1 
Broad Tumor PortalCLIP1
OASIS PortalCLIP1 [ Somatic mutations - Copy number]
Cancer Gene: CensusCLIP1 
Somatic Mutations in Cancer : COSMICCLIP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCLIP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CLIP1
DgiDB (Drug Gene Interaction Database)CLIP1
DoCM (Curated mutations)CLIP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CLIP1 (select a term)
intoGenCLIP1
Cancer3DCLIP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM179838   
Orphanet11804   
MedgenCLIP1
Genetic Testing Registry CLIP1
NextProtP30622 [Medical]
TSGene6249
GENETestsCLIP1
Target ValidationCLIP1
Huge Navigator CLIP1 [HugePedia]
snp3D : Map Gene to Disease6249
BioCentury BCIQCLIP1
ClinGenCLIP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6249
Chemical/Pharm GKB GenePA162382349
Clinical trialCLIP1
Miscellaneous
canSAR (ICR)CLIP1 (select the gene name)
Probes
Litterature
PubMed75 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCLIP1
EVEXCLIP1
GoPubMedCLIP1
iHOPCLIP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:50:05 CEST 2017

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