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CLK2 (CDC like kinase 2)

Identity

Alias (NCBI)-
HGNC (Hugo) CLK2
HGNC Previous nameCDC-like kinase 2
LocusID (NCBI) 1196
Atlas_Id 40103
Location 1q22  [Link to chromosome band 1q22]
Location_base_pair Starts at 155262868 and ends at 155273504 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CLK2 (1q22) / ASH1L (1q22)CLK2 (1q22) / CD244 (1q23.3)CLK2 (1q22) / DLGAP1 (18p11.31)
CLK2 (1q22) / PAFAH1B3 (19q13.2)DXO (6p21.33) / CLK2 (1q22)PAFAH1B3 (19q13.2) / CLK2 (1q22)
RBM19 (12q24.13) / CLK2 (1q22)CLK2 1q22 / ASH1L 1q22CLK2 1q22 / CD244 1q23.3
RBM19 12q24.13 / CLK2 1q22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CLK2   2069
Cards
Entrez_Gene (NCBI)CLK2    CDC like kinase 2
Aliases
GeneCards (Weizmann)CLK2
Ensembl hg19 (Hinxton)ENSG00000176444 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000176444 [Gene_View]  ENSG00000176444 [Sequence]  chr1:155262868-155273504 [Contig_View]  CLK2 [Vega]
ICGC DataPortalENSG00000176444
TCGA cBioPortalCLK2
AceView (NCBI)CLK2
Genatlas (Paris)CLK2
SOURCE (Princeton)CLK2
Genetics Home Reference (NIH)CLK2
Genomic and cartography
GoldenPath hg38 (UCSC)CLK2  -     chr1:155262868-155273504 -  1q22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CLK2  -     1q22   [Description]    (hg19-Feb_2009)
GoldenPathCLK2 - 1q22 [CytoView hg19]  CLK2 - 1q22 [CytoView hg38]
ImmunoBaseENSG00000176444
Genome Data Viewer NCBICLK2 [Mapview hg19]  
OMIM602989   
Gene and transcription
Genbank (Entrez)AK091036 AK291995 AK303696 AU136826 BC006274
RefSeq transcript (Entrez)NM_001291 NM_001294338 NM_001294339 NM_001363704 NM_003993
Consensus coding sequences : CCDS (NCBI)CLK2
Gene ExpressionCLK2 [ NCBI-GEO ]   CLK2 [ EBI - ARRAY_EXPRESS ]   CLK2 [ SEEK ]   CLK2 [ MEM ]
Gene Expression Viewer (FireBrowse)CLK2 [ Firebrowse - Broad ]
GenevisibleExpression of CLK2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1196
GTEX Portal (Tissue expression)CLK2
Human Protein AtlasENSG00000176444-CLK2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49760   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49760  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49760
Catalytic activity : Enzyme2.7.12.1 [ Enzyme-Expasy ]   2.7.12.12.7.12.1 [ IntEnz-EBI ]   2.7.12.1 [ BRENDA ]   2.7.12.1 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP49760
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CLK2
PDB (RSDB)3NR9    5UNP    6FYI    6FYK    6FYL    6KHE   
PDB Europe3NR9    5UNP    6FYI    6FYK    6FYL    6KHE   
PDB (PDBSum)3NR9    5UNP    6FYI    6FYK    6FYL    6KHE   
PDB (IMB)3NR9    5UNP    6FYI    6FYK    6FYL    6KHE   
Structural Biology KnowledgeBase3NR9    5UNP    6FYI    6FYK    6FYL    6KHE   
SCOP (Structural Classification of Proteins)3NR9    5UNP    6FYI    6FYK    6FYL    6KHE   
CATH (Classification of proteins structures)3NR9    5UNP    6FYI    6FYK    6FYL    6KHE   
SuperfamilyP49760
AlphaFold pdb e-kbP49760   
Human Protein Atlas [tissue]ENSG00000176444-CLK2 [tissue]
HPRD04289
Protein Interaction databases
DIP (DOE-UCLA)P49760
IntAct (EBI)P49760
BioGRIDCLK2
STRING (EMBL)CLK2
ZODIACCLK2
Ontologies - Pathways
QuickGOP49760
Ontology : AmiGOprotein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  protein phosphorylation  response to ionizing radiation  nuclear body  nuclear speck  peptidyl-tyrosine phosphorylation  identical protein binding  regulation of RNA splicing  negative regulation of gluconeogenesis  protein autophosphorylation  protein serine kinase activity  protein threonine kinase activity  
Ontology : EGO-EBIprotein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  protein phosphorylation  response to ionizing radiation  nuclear body  nuclear speck  peptidyl-tyrosine phosphorylation  identical protein binding  regulation of RNA splicing  negative regulation of gluconeogenesis  protein autophosphorylation  protein serine kinase activity  protein threonine kinase activity  
NDEx NetworkCLK2
Atlas of Cancer Signalling NetworkCLK2
Wikipedia pathwaysCLK2
Orthology - Evolution
OrthoDB1196
GeneTree (enSembl)ENSG00000176444
Phylogenetic Trees/Animal Genes : TreeFamCLK2
Homologs : HomoloGeneCLK2
Homology/Alignments : Family Browser (UCSC)CLK2
Gene fusions - Rearrangements
Fusion : MitelmanCLK2/CD244 [1q22/1q23.3]  
Fusion : MitelmanRBM19/CLK2 [12q24.13/1q22]  
Fusion : QuiverCLK2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCLK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CLK2
dbVarCLK2
ClinVarCLK2
MonarchCLK2
1000_GenomesCLK2 
Exome Variant ServerCLK2
GNOMAD BrowserENSG00000176444
Varsome BrowserCLK2
ACMGCLK2 variants
VarityP49760
Genomic Variants (DGV)CLK2 [DGVbeta]
DECIPHERCLK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCLK2 
Mutations
ICGC Data PortalCLK2 
TCGA Data PortalCLK2 
Broad Tumor PortalCLK2
OASIS PortalCLK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCLK2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCLK2
Mutations and Diseases : HGMDCLK2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCLK2
DgiDB (Drug Gene Interaction Database)CLK2
DoCM (Curated mutations)CLK2
CIViC (Clinical Interpretations of Variants in Cancer)CLK2
Cancer3DCLK2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602989   
Orphanet
DisGeNETCLK2
MedgenCLK2
Genetic Testing Registry CLK2
NextProtP49760 [Medical]
GENETestsCLK2
Target ValidationCLK2
Huge Navigator CLK2 [HugePedia]
ClinGenCLK2
Clinical trials, drugs, therapy
MyCancerGenomeCLK2
Protein Interactions : CTDCLK2
Pharm GKB GenePA26595
PharosP49760
Clinical trialCLK2
Miscellaneous
canSAR (ICR)CLK2
HarmonizomeCLK2
DataMed IndexCLK2
Probes
Litterature
PubMed55 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCLK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:04:21 CEST 2021

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