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CLK2 (CDC like kinase 2)

Identity

Alias_namesCDC-like kinase 2
Alias_symbol (synonym)clk2
Other alias-
HGNC (Hugo) CLK2
LocusID (NCBI) 1196
Atlas_Id 40103
Location 1q22  [Link to chromosome band 1q22]
Location_base_pair Starts at 155262868 and ends at 155273529 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CLK2 (1q22) / ASH1L (1q22)CLK2 (1q22) / CD244 (1q23.3)CLK2 (1q22) / DLGAP1 (18p11.31)
CLK2 (1q22) / PAFAH1B3 (19q13.2)DXO (6p21.33) / CLK2 (1q22)PAFAH1B3 (19q13.2) / CLK2 (1q22)
RBM19 (12q24.13) / CLK2 (1q22)CLK2 1q22 / ASH1L 1q22CLK2 1q22 / CD244 1q23.3
RBM19 12q24.13 / CLK2 1q22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;1)(q22;q23) CLK2/CD244


External links

Nomenclature
HGNC (Hugo)CLK2   2069
Cards
Entrez_Gene (NCBI)CLK2  1196  CDC like kinase 2
Aliases
GeneCards (Weizmann)CLK2
Ensembl hg19 (Hinxton)ENSG00000176444 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000176444 [Gene_View]  ENSG00000176444 [Sequence]  chr1:155262868-155273529 [Contig_View]  CLK2 [Vega]
ICGC DataPortalENSG00000176444
TCGA cBioPortalCLK2
AceView (NCBI)CLK2
Genatlas (Paris)CLK2
WikiGenes1196
SOURCE (Princeton)CLK2
Genetics Home Reference (NIH)CLK2
Genomic and cartography
GoldenPath hg38 (UCSC)CLK2  -     chr1:155262868-155273529 -  1q22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CLK2  -     1q22   [Description]    (hg19-Feb_2009)
EnsemblCLK2 - 1q22 [CytoView hg19]  CLK2 - 1q22 [CytoView hg38]
Mapping of homologs : NCBICLK2 [Mapview hg19]  CLK2 [Mapview hg38]
OMIM602989   
Gene and transcription
Genbank (Entrez)AK091036 AK291995 AK303696 AU136826 BC006274
RefSeq transcript (Entrez)NM_001291 NM_001294338 NM_001294339 NM_003993
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CLK2
Cluster EST : UnigeneHs.73986 [ NCBI ]
CGAP (NCI)Hs.73986
Alternative Splicing GalleryENSG00000176444
Gene ExpressionCLK2 [ NCBI-GEO ]   CLK2 [ EBI - ARRAY_EXPRESS ]   CLK2 [ SEEK ]   CLK2 [ MEM ]
Gene Expression Viewer (FireBrowse)CLK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1196
GTEX Portal (Tissue expression)CLK2
Human Protein AtlasENSG00000176444-CLK2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49760   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49760  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49760
Splice isoforms : SwissVarP49760
Catalytic activity : Enzyme2.7.12.1 [ Enzyme-Expasy ]   2.7.12.12.7.12.1 [ IntEnz-EBI ]   2.7.12.1 [ BRENDA ]   2.7.12.1 [ KEGG ]   
PhosPhoSitePlusP49760
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CLK2
DMDM Disease mutations1196
Blocks (Seattle)CLK2
PDB (SRS)3NR9   
PDB (PDBSum)3NR9   
PDB (IMB)3NR9   
PDB (RSDB)3NR9   
Structural Biology KnowledgeBase3NR9   
SCOP (Structural Classification of Proteins)3NR9   
CATH (Classification of proteins structures)3NR9   
SuperfamilyP49760
Human Protein Atlas [tissue]ENSG00000176444-CLK2 [tissue]
Peptide AtlasP49760
HPRD04289
IPIIPI00028071   IPI00937288   IPI00643082   IPI00902546   IPI00478691   
Protein Interaction databases
DIP (DOE-UCLA)P49760
IntAct (EBI)P49760
FunCoupENSG00000176444
BioGRIDCLK2
STRING (EMBL)CLK2
ZODIACCLK2
Ontologies - Pathways
QuickGOP49760
Ontology : AmiGOprotein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  protein phosphorylation  response to ionizing radiation  nuclear body  nuclear speck  peptidyl-tyrosine phosphorylation  response to retinoic acid  identical protein binding  regulation of RNA splicing  negative regulation of gluconeogenesis  protein autophosphorylation  
Ontology : EGO-EBIprotein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  protein phosphorylation  response to ionizing radiation  nuclear body  nuclear speck  peptidyl-tyrosine phosphorylation  response to retinoic acid  identical protein binding  regulation of RNA splicing  negative regulation of gluconeogenesis  protein autophosphorylation  
NDEx NetworkCLK2
Atlas of Cancer Signalling NetworkCLK2
Wikipedia pathwaysCLK2
Orthology - Evolution
OrthoDB1196
GeneTree (enSembl)ENSG00000176444
Phylogenetic Trees/Animal Genes : TreeFamCLK2
HOVERGENP49760
HOGENOMP49760
Homologs : HomoloGeneCLK2
Homology/Alignments : Family Browser (UCSC)CLK2
Gene fusions - Rearrangements
Fusion : MitelmanCLK2/CD244 [1q22/1q23.3]  
Fusion : MitelmanRBM19/CLK2 [12q24.13/1q22]  [t(1;12)(q22;q24)]  
Fusion PortalCLK2 1q22 ASH1L 1q22 LUAD
Fusion PortalCLK2 1q22 CD244 1q23.3 BRCA
Fusion PortalRBM19 12q24.13 CLK2 1q22 PRAD
Fusion : QuiverCLK2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCLK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CLK2
dbVarCLK2
ClinVarCLK2
1000_GenomesCLK2 
Exome Variant ServerCLK2
ExAC (Exome Aggregation Consortium)ENSG00000176444
GNOMAD BrowserENSG00000176444
Genetic variants : HAPMAP1196
Genomic Variants (DGV)CLK2 [DGVbeta]
DECIPHERCLK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCLK2 
Mutations
ICGC Data PortalCLK2 
TCGA Data PortalCLK2 
Broad Tumor PortalCLK2
OASIS PortalCLK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCLK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCLK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CLK2
DgiDB (Drug Gene Interaction Database)CLK2
DoCM (Curated mutations)CLK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CLK2 (select a term)
intoGenCLK2
Cancer3DCLK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602989   
Orphanet
DisGeNETCLK2
MedgenCLK2
Genetic Testing Registry CLK2
NextProtP49760 [Medical]
TSGene1196
GENETestsCLK2
Target ValidationCLK2
Huge Navigator CLK2 [HugePedia]
snp3D : Map Gene to Disease1196
BioCentury BCIQCLK2
ClinGenCLK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1196
Chemical/Pharm GKB GenePA26595
Clinical trialCLK2
Miscellaneous
canSAR (ICR)CLK2 (select the gene name)
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCLK2
EVEXCLK2
GoPubMedCLK2
iHOPCLK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:19:52 CEST 2018

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