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CLK3 (CDC like kinase 3)

Identity

Other namesPHCLK3
PHCLK3/152
HGNC (Hugo) CLK3
LocusID (NCBI) 1198
Atlas_Id 40104
Location 15q24.1  [Link to chromosome band 15q24]
Location_base_pair Starts at 74907335 and ends at 74922542 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CLK3 (15q24.1) / ZSWIM7 (17p12)DYRK1A (21q22.13) / CLK3 (15q24.1)SKI (1p36.33) / CLK3 (15q24.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CLK3   2071
Cards
Entrez_Gene (NCBI)CLK3  1198  CDC like kinase 3
AliasesPHCLK3; PHCLK3/152
GeneCards (Weizmann)CLK3
Ensembl hg19 (Hinxton)ENSG00000179335 [Gene_View]  chr15:74907335-74922542 [Contig_View]  CLK3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000179335 [Gene_View]  chr15:74907335-74922542 [Contig_View]  CLK3 [Vega]
ICGC DataPortalENSG00000179335
TCGA cBioPortalCLK3
AceView (NCBI)CLK3
Genatlas (Paris)CLK3
WikiGenes1198
SOURCE (Princeton)CLK3
Genomic and cartography
GoldenPath hg19 (UCSC)CLK3  -     chr15:74907335-74922542 +  15q24.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CLK3  -     15q24.1   [Description]    (hg38-Dec_2013)
EnsemblCLK3 - 15q24.1 [CytoView hg19]  CLK3 - 15q24.1 [CytoView hg38]
Mapping of homologs : NCBICLK3 [Mapview hg19]  CLK3 [Mapview hg38]
OMIM602990   
Gene and transcription
Genbank (Entrez)AB209535 AK026511 AK091692 AK095335 AK096115
RefSeq transcript (Entrez)NM_001130028 NM_001292 NM_003992
RefSeq genomic (Entrez)NC_000015 NC_018926 NT_010194 NW_004929398
Consensus coding sequences : CCDS (NCBI)CLK3
Cluster EST : UnigeneHs.584748 [ NCBI ]
CGAP (NCI)Hs.584748
Alternative Splicing GalleryENSG00000179335
Gene ExpressionCLK3 [ NCBI-GEO ]   CLK3 [ EBI - ARRAY_EXPRESS ]   CLK3 [ SEEK ]   CLK3 [ MEM ]
Gene Expression Viewer (FireBrowse)CLK3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1198
GTEX Portal (Tissue expression)CLK3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49761 (Uniprot)
NextProtP49761  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49761
Splice isoforms : SwissVarP49761 (Swissvar)
Catalytic activity : Enzyme2.7.12.1 [ Enzyme-Expasy ]   2.7.12.12.7.12.1 [ IntEnz-EBI ]   2.7.12.1 [ BRENDA ]   2.7.12.1 [ KEGG ]   
PhosPhoSitePlusP49761
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
DMDM Disease mutations1198
Blocks (Seattle)CLK3
PDB (SRS)2EU9    2EXE    2WU6    2WU7    3RAW   
PDB (PDBSum)2EU9    2EXE    2WU6    2WU7    3RAW   
PDB (IMB)2EU9    2EXE    2WU6    2WU7    3RAW   
PDB (RSDB)2EU9    2EXE    2WU6    2WU7    3RAW   
Structural Biology KnowledgeBase2EU9    2EXE    2WU6    2WU7    3RAW   
SCOP (Structural Classification of Proteins)2EU9    2EXE    2WU6    2WU7    3RAW   
CATH (Classification of proteins structures)2EU9    2EXE    2WU6    2WU7    3RAW   
SuperfamilyP49761
Human Protein AtlasENSG00000179335
Peptide AtlasP49761
HPRD04290
IPIIPI00298896   IPI00219340   IPI00219341   IPI00847415   IPI00910193   IPI00902581   
Protein Interaction databases
DIP (DOE-UCLA)P49761
IntAct (EBI)P49761
FunCoupENSG00000179335
BioGRIDCLK3
STRING (EMBL)CLK3
ZODIACCLK3
Ontologies - Pathways
QuickGOP49761
Ontology : AmiGOacrosomal vesicle  protein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  protein phosphorylation  membrane  nuclear speck  peptidyl-tyrosine phosphorylation  regulation of RNA splicing  poly(A) RNA binding  intermediate filament cytoskeleton  protein autophosphorylation  
Ontology : EGO-EBIacrosomal vesicle  protein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  protein phosphorylation  membrane  nuclear speck  peptidyl-tyrosine phosphorylation  regulation of RNA splicing  poly(A) RNA binding  intermediate filament cytoskeleton  protein autophosphorylation  
NDEx NetworkCLK3
Atlas of Cancer Signalling NetworkCLK3
Wikipedia pathwaysCLK3
Orthology - Evolution
OrthoDB1198
GeneTree (enSembl)ENSG00000179335
Phylogenetic Trees/Animal Genes : TreeFamCLK3
Homologs : HomoloGeneCLK3
Homology/Alignments : Family Browser (UCSC)CLK3
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerCLK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CLK3
dbVarCLK3
ClinVarCLK3
1000_GenomesCLK3 
Exome Variant ServerCLK3
ExAC (Exome Aggregation Consortium)CLK3 (select the gene name)
Genetic variants : HAPMAP1198
Genomic Variants (DGV)CLK3 [DGVbeta]
Mutations
ICGC Data PortalCLK3 
TCGA Data PortalCLK3 
Broad Tumor PortalCLK3
OASIS PortalCLK3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCLK3 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CLK3
DgiDB (Drug Gene Interaction Database)CLK3
DoCM (Curated mutations)CLK3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CLK3 (select a term)
intoGenCLK3
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)15:74907335-74922542  ENSG00000179335
CONAN: Copy Number AnalysisCLK3 
Mutations and Diseases : HGMDCLK3
OMIM602990   
MedgenCLK3
Genetic Testing Registry CLK3
NextProtP49761 [Medical]
TSGene1198
GENETestsCLK3
Huge Navigator CLK3 [HugePedia]
snp3D : Map Gene to Disease1198
BioCentury BCIQCLK3
ClinGenCLK3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1198
Chemical/Pharm GKB GenePA26597
Clinical trialCLK3
Miscellaneous
canSAR (ICR)CLK3 (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCLK3
EVEXCLK3
GoPubMedCLK3
iHOPCLK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 19 18:42:54 CEST 2016

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