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CLK3 (CDC-like kinase 3)

Identity

Other namesPHCLK3
PHCLK3/152
HGNC (Hugo) CLK3
LocusID (NCBI) 1198
Location 15q24.1
Location_base_pair Starts at 74907335 and ends at 74922542 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CLK3   2071
Entrez_Gene (NCBI)CLK3  1198  CDC-like kinase 3
Cards
GeneCards (Weizmann)CLK3
Ensembl (Hinxton)ENSG00000179335 [Gene_View]  chr15:74907335-74922542 [Contig_View]  CLK3 [Vega]
AceView (NCBI)CLK3
Genatlas (Paris)CLK3
SOURCE (Stanford)NM_001130028 NM_001292 NM_003992
Genomic and cartography
GoldenPath (UCSC)CLK3  -  15q24.1   chr15:74907335-74922542 +  15q24.1   [Description]    (hg19-Feb_2009)
EnsemblCLK3 - 15q24.1 [CytoView]
Mapping of homologs : NCBICLK3 [Mapview]
OMIM602990   
Gene and transcription
Genbank (Entrez)AB209535 AK026511 AK091692 AK096115 AK097982
RefSeq transcript (SRS)NM_001130028 NM_001292 NM_003992
RefSeq transcript (Entrez)NM_001130028 NM_001292 NM_003992
RefSeq genomic (SRS)AC_000147 NC_000015 NC_018926 NT_010194 NW_001838219 NW_004078084
RefSeq genomic (Entrez)AC_000147 NC_000015 NC_018926 NT_010194 NW_001838219 NW_004078084
Consensus coding sequences : CCDS (NCBI)CLK3
Cluster EST : UnigeneHs.584748 [ SRS ] Hs.584748 [ NCBI ]
CGAP (NCI)Hs.584748
Alternative Splicing : Fast-db (Paris)GSHG0033226
Alternative Splicing GalleryENSG00000179335
Gene ExpressionCLK3 [ NCBI-GEO ]   CLK3 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49761 (SRS) P49761 (Uniprot)
NextProtP49761
With graphics : InterProP49761
Splice isoforms : SwissVarP49761(Swissvar)
Domaine pattern : Prosite (SRS)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (SRS)Kinase-like_dom    Prot_kinase_cat_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase_dom    Ser/Thr_kinase_AS   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_cat_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase_dom    Ser/Thr_kinase_AS   
Related proteins : CluSTrP49761
Domain families : Pfam (SRS)Pkinase (PF00069)   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
DMDM1198
Blocks (Seattle)P49761
PDB (SRS)2EU9    2EXE    2WU6    2WU7    3RAW   
PDB (PDBSum)2EU9    2EXE    2WU6    2WU7    3RAW   
PDB (IMB)2EU9    2EXE    2WU6    2WU7    3RAW   
PDB (RSDB)2EU9    2EXE    2WU6    2WU7    3RAW   
Human Protein AtlasENSG00000179335
HPRD04290
IPIIPI00298896   IPI00219340   IPI00219341   IPI00847415   IPI00910193   IPI00902581   
Protein Interaction databases
DIP (DOE-UCLA)P49761
IntAct (EBI)P49761
FunCoupENSG00000179335
REACTOMECLK3
Protein Interaction Database1198
BioGRIDCLK3
InParanoidP49761
Interologous Interaction database P49761
IntegromeDBCLK3
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)CLK3
SNP (GeneSNP Utah)CLK3
SNP : HGBaseCLK3
Genetic variants : HAPMAPCLK3
Somatic Mutations in Cancer : COSMICCLK3 
CONAN: Copy Number AnalysisCLK3 
Mutations and Diseases : HGMDCLK3
OMIM602990   
GENETests602990   
Disease Genetic AssociationCLK3
Huge Navigator CLK3 [HugePedia]  CLK3 [HugeCancerGEM]
Genomic VariantsCLK3  CLK3 [DGVbeta]
ClinVarCLK3
snp3D : Map Gene to Disease1198
General knowledge
Homologs : HomoloGeneCLK3
Homology/Alignments : Family Browser (UCSC)CLK3
Phylogenetic Trees/Animal Genes : TreeFamCLK3
Catalytic activity : Enzyme2.7.12.1 [ Enzyme-Expasy ]   2.7.12.1 [ Enzyme-SRS ]   2.7.12.1 [ IntEnz-EBI ]   2.7.12.1 [ BRENDA ]   2.7.12.1 [ KEGG ]   
Chemical/Protein Interactions : CTD1198
Chemical/Pharm GKB GenePA26597
Clinical trialCLK3
Cancer Resource (Charite)ENSG00000179335
Ontology : AmiGOacrosomal vesicle  protein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  ATP binding  nucleus  nucleolus  protein phosphorylation  nuclear speck  peptidyl-tyrosine phosphorylation  regulation of RNA splicing  intermediate filament cytoskeleton  protein autophosphorylation  
Ontology : EGO-EBIacrosomal vesicle  protein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  ATP binding  nucleus  nucleolus  protein phosphorylation  nuclear speck  peptidyl-tyrosine phosphorylation  regulation of RNA splicing  intermediate filament cytoskeleton  protein autophosphorylation  
Other databases
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
PubGeneCLK3
iHOPCLK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 14 17:52:27 CEST 2013
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