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CLK4 (CDC like kinase 4)

Identity

Alias_namesCDC-like kinase 4
Other alias-
HGNC (Hugo) CLK4
LocusID (NCBI) 57396
Atlas_Id 43216
Location 5q35.3  [Link to chromosome band 5q35]
Location_base_pair Starts at 178602664 and ends at 178627053 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CLK4 (5q35.3) / ATP2C1 (3q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CLK4   13659
Cards
Entrez_Gene (NCBI)CLK4  57396  CDC like kinase 4
Aliases
GeneCards (Weizmann)CLK4
Ensembl hg19 (Hinxton)ENSG00000113240 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000113240 [Gene_View]  chr5:178602664-178627053 [Contig_View]  CLK4 [Vega]
ICGC DataPortalENSG00000113240
TCGA cBioPortalCLK4
AceView (NCBI)CLK4
Genatlas (Paris)CLK4
WikiGenes57396
SOURCE (Princeton)CLK4
Genetics Home Reference (NIH)CLK4
Genomic and cartography
GoldenPath hg38 (UCSC)CLK4  -     chr5:178602664-178627053 -  5q35.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CLK4  -     5q35.3   [Description]    (hg19-Feb_2009)
EnsemblCLK4 - 5q35.3 [CytoView hg19]  CLK4 - 5q35.3 [CytoView hg38]
Mapping of homologs : NCBICLK4 [Mapview hg19]  CLK4 [Mapview hg38]
OMIM607969   
Gene and transcription
Genbank (Entrez)AF294429 AK294921 AK304614 AK308578 AK308674
RefSeq transcript (Entrez)NM_020666
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CLK4
Cluster EST : UnigeneHs.406557 [ NCBI ]
CGAP (NCI)Hs.406557
Alternative Splicing GalleryENSG00000113240
Gene ExpressionCLK4 [ NCBI-GEO ]   CLK4 [ EBI - ARRAY_EXPRESS ]   CLK4 [ SEEK ]   CLK4 [ MEM ]
Gene Expression Viewer (FireBrowse)CLK4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57396
GTEX Portal (Tissue expression)CLK4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HAZ1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HAZ1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HAZ1
Splice isoforms : SwissVarQ9HAZ1
Catalytic activity : Enzyme2.7.12.1 [ Enzyme-Expasy ]   2.7.12.12.7.12.1 [ IntEnz-EBI ]   2.7.12.1 [ BRENDA ]   2.7.12.1 [ KEGG ]   
PhosPhoSitePlusQ9HAZ1
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CLK4
DMDM Disease mutations57396
Blocks (Seattle)CLK4
SuperfamilyQ9HAZ1
Human Protein AtlasENSG00000113240
Peptide AtlasQ9HAZ1
HPRD12140
IPIIPI00180143   IPI00976706   IPI00977343   IPI00979074   IPI00978382   
Protein Interaction databases
DIP (DOE-UCLA)Q9HAZ1
IntAct (EBI)Q9HAZ1
FunCoupENSG00000113240
BioGRIDCLK4
STRING (EMBL)CLK4
ZODIACCLK4
Ontologies - Pathways
QuickGOQ9HAZ1
Ontology : AmiGOprotein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  nucleus  peptidyl-tyrosine phosphorylation  regulation of RNA splicing  protein autophosphorylation  
Ontology : EGO-EBIprotein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  nucleus  peptidyl-tyrosine phosphorylation  regulation of RNA splicing  protein autophosphorylation  
NDEx NetworkCLK4
Atlas of Cancer Signalling NetworkCLK4
Wikipedia pathwaysCLK4
Orthology - Evolution
OrthoDB57396
GeneTree (enSembl)ENSG00000113240
Phylogenetic Trees/Animal Genes : TreeFamCLK4
HOVERGENQ9HAZ1
HOGENOMQ9HAZ1
Homologs : HomoloGeneCLK4
Homology/Alignments : Family Browser (UCSC)CLK4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCLK4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CLK4
dbVarCLK4
ClinVarCLK4
1000_GenomesCLK4 
Exome Variant ServerCLK4
ExAC (Exome Aggregation Consortium)CLK4 (select the gene name)
Genetic variants : HAPMAP57396
Genomic Variants (DGV)CLK4 [DGVbeta]
DECIPHERCLK4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCLK4 
Mutations
ICGC Data PortalCLK4 
TCGA Data PortalCLK4 
Broad Tumor PortalCLK4
OASIS PortalCLK4 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDCLK4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CLK4
DgiDB (Drug Gene Interaction Database)CLK4
DoCM (Curated mutations)CLK4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CLK4 (select a term)
intoGenCLK4
Cancer3DCLK4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607969   
Orphanet
MedgenCLK4
Genetic Testing Registry CLK4
NextProtQ9HAZ1 [Medical]
TSGene57396
GENETestsCLK4
Target ValidationCLK4
Huge Navigator CLK4 [HugePedia]
snp3D : Map Gene to Disease57396
BioCentury BCIQCLK4
ClinGenCLK4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57396
Chemical/Pharm GKB GenePA26598
Clinical trialCLK4
Miscellaneous
canSAR (ICR)CLK4 (select the gene name)
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCLK4
EVEXCLK4
GoPubMedCLK4
iHOPCLK4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:28:44 CEST 2017

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