| Nomenclature |
|---|
| HGNC (Hugo) | CLOCK 2082 |
| Cards |
|---|
| Entrez_Gene (NCBI) | CLOCK 9575 clock circadian regulator |
| Aliases | KAT13D; bHLHe8 |
| GeneCards (Weizmann) | CLOCK |
| Ensembl hg19 (Hinxton) | ENSG00000134852 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000134852 [Gene_View] chr4:55427901-55546909 [Contig_View] CLOCK [Vega] |
| ICGC DataPortal | ENSG00000134852 |
| TCGA cBioPortal | CLOCK |
| AceView (NCBI) | CLOCK |
| Genatlas (Paris) | CLOCK |
| WikiGenes | 9575 |
| SOURCE (Princeton) | CLOCK |
| Genetics Home Reference (NIH) | CLOCK |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | CLOCK - chr4:55427901-55546909 - 4q12 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | CLOCK - 4q12 [Description] (hg19-Feb_2009) |
| Ensembl | CLOCK - 4q12 [CytoView hg19] CLOCK - 4q12 [CytoView hg38] |
| Mapping of homologs : NCBI | CLOCK [Mapview hg19] CLOCK [Mapview hg38] |
| OMIM | 601851 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AB002332 AB005535 AF011568 AK096319 AK124437 |
| RefSeq transcript (Entrez) | NM_001267843 NM_004898 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | CLOCK |
| Cluster EST : Unigene | Hs.689578 [ NCBI ] |
| CGAP (NCI) | Hs.689578 |
| Alternative Splicing Gallery | ENSG00000134852 |
| Gene Expression | CLOCK [ NCBI-GEO ] CLOCK [ EBI - ARRAY_EXPRESS ]
CLOCK [ SEEK ] CLOCK [ MEM ] |
| Gene Expression Viewer (FireBrowse) | CLOCK [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 9575 |
| GTEX Portal (Tissue expression) | CLOCK |
| Human Protein Atlas | ENSG00000134852-CLOCK [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | O15516 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | O15516 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | O15516 |
| Splice isoforms : SwissVar | O15516 |
| Catalytic activity : Enzyme | 2.3.1.48 [ Enzyme-Expasy ] 2.3.1.482.3.1.48 [ IntEnz-EBI ] 2.3.1.48 [ BRENDA ] 2.3.1.48 [ KEGG ] |
| PhosPhoSitePlus | O15516 |
| Domaine pattern : Prosite (Expaxy) | BHLH (PS50888) PAS (PS50112) |
| Domains : Interpro (EBI) | bHLH_dom Nuc_translocat PAC PAS PAS_fold |
| Domain families : Pfam (Sanger) | HLH (PF00010) PAS (PF00989) |
| Domain families : Pfam (NCBI) | pfam00010 pfam00989 |
| Domain families : Smart (EMBL) | HLH (SM00353) PAC (SM00086) PAS (SM00091) |
| Conserved Domain (NCBI) | CLOCK |
| DMDM Disease mutations | 9575 |
| Blocks (Seattle) | CLOCK |
| PDB (SRS) | 4H10 |
| PDB (PDBSum) | 4H10 |
| PDB (IMB) | 4H10 |
| PDB (RSDB) | 4H10 |
| Structural Biology KnowledgeBase | 4H10 |
| SCOP (Structural Classification of Proteins) | 4H10 |
| CATH (Classification of proteins structures) | 4H10 |
| Superfamily | O15516 |
| Human Protein Atlas [tissue] | ENSG00000134852-CLOCK [tissue] |
| Peptide Atlas | O15516 |
| HPRD | 03508 |
| IPI | IPI00007284 IPI00853422 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | O15516 |
| IntAct (EBI) | O15516 |
| FunCoup | ENSG00000134852 |
| BioGRID | CLOCK |
| STRING (EMBL) | CLOCK |
| ZODIAC | CLOCK |
| Ontologies - Pathways |
|---|
| QuickGO | O15516 |
| Ontology : AmiGO | DNA damage checkpoint RNA polymerase II proximal promoter sequence-specific DNA binding transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding core promoter sequence-specific DNA binding core promoter binding transcriptional activator activity, RNA polymerase II transcription factor binding DNA binding DNA binding transcription factor activity histone acetyltransferase activity protein binding nucleus nucleoplasm nucleoplasm transcription factor complex chromosome cytosol regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II transcription by RNA polymerase II protein acetylation signal transduction spermatogenesis circadian rhythm photoperiodism histone acetylation chromatin DNA binding circadian regulation of gene expression circadian regulation of gene expression circadian regulation of gene expression chromatoid body regulation of hair cycle proteasome-mediated ubiquitin-dependent protein catabolic process intracellular membrane-bounded organelle sequence-specific DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II protein dimerization activity positive regulation of inflammatory response regulation of insulin secretion positive regulation of NF-kappaB transcription factor activity response to redox state E-box binding cellular response to ionizing radiation regulation of type B pancreatic cell development negative regulation of glucocorticoid receptor signaling pathway |
| Ontology : EGO-EBI | DNA damage checkpoint RNA polymerase II proximal promoter sequence-specific DNA binding transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding core promoter sequence-specific DNA binding core promoter binding transcriptional activator activity, RNA polymerase II transcription factor binding DNA binding DNA binding transcription factor activity histone acetyltransferase activity protein binding nucleus nucleoplasm nucleoplasm transcription factor complex chromosome cytosol regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II transcription by RNA polymerase II protein acetylation signal transduction spermatogenesis circadian rhythm photoperiodism histone acetylation chromatin DNA binding circadian regulation of gene expression circadian regulation of gene expression circadian regulation of gene expression chromatoid body regulation of hair cycle proteasome-mediated ubiquitin-dependent protein catabolic process intracellular membrane-bounded organelle sequence-specific DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II protein dimerization activity positive regulation of inflammatory response regulation of insulin secretion positive regulation of NF-kappaB transcription factor activity response to redox state E-box binding cellular response to ionizing radiation regulation of type B pancreatic cell development negative regulation of glucocorticoid receptor signaling pathway |
| Pathways : BIOCARTA | Circadian Rhythms [Genes] |
| Pathways : KEGG | Circadian rhythm |
| NDEx Network | CLOCK |
| Atlas of Cancer Signalling Network | CLOCK |
| Wikipedia pathways | CLOCK |
| Orthology - Evolution |
|---|
| OrthoDB | 9575 |
| GeneTree (enSembl) | ENSG00000134852 |
| Phylogenetic Trees/Animal Genes : TreeFam | CLOCK |
| HOVERGEN | O15516 |
| HOGENOM | O15516 |
| Homologs : HomoloGene | CLOCK |
| Homology/Alignments : Family Browser (UCSC) | CLOCK |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | CLOCK/PHF21A [4q12/11p11.2] |
| Fusion : Mitelman | CLOCK/UGT2A3 [4q12/4q13.2] [t(4;4)(q12;q13)] |
| Fusion: TCGA_MDACC | CLOCK 4q12 NMU 4q12 LUAD |
| Fusion: TCGA_MDACC | CLOCK 4q12 PDGFRA 4q12 LUAD |
| Fusion: TCGA_MDACC | CLOCK 4q12 PHF21A 11p11.2 LUAD |
| Fusion: TCGA_MDACC | CLOCK 4q12 SRD5A3 4q12 LUSC |
| Fusion: TCGA_MDACC | CLOCK 4q12 UGT2A3 4q13.2 BLCA |
| Fusion Portal | CLOCK 4q12 NMU 4q12 LUAD |
| Fusion Portal | CLOCK 4q12 PDGFRA 4q12 LUAD |
| Fusion Portal | CLOCK 4q12 PHF21A 11p11.2 LUAD |
| Fusion Portal | CLOCK 4q12 SRD5A3 4q12 LUSC |
| Fusion Portal | CLOCK 4q12 UGT2A3 4q13.2 BLCA |
| Fusion : Quiver | CLOCK |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | CLOCK [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | CLOCK |
| dbVar | CLOCK |
| ClinVar | CLOCK |
| 1000_Genomes | CLOCK |
| Exome Variant Server | CLOCK |
| ExAC (Exome Aggregation Consortium) | ENSG00000134852 |
| GNOMAD Browser | ENSG00000134852 |
| Genetic variants : HAPMAP | 9575 |
| Genomic Variants (DGV) | CLOCK [DGVbeta] |
| DECIPHER | CLOCK [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | CLOCK |
| Mutations |
|---|
| ICGC Data Portal | CLOCK |
| TCGA Data Portal | CLOCK |
| Broad Tumor Portal | CLOCK |
| OASIS Portal | CLOCK [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | CLOCK [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | CLOCK |
| intOGen Portal | CLOCK |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search CLOCK |
| DgiDB (Drug Gene Interaction Database) | CLOCK |
| DoCM (Curated mutations) | CLOCK (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | CLOCK (select a term) |
| intoGen | CLOCK |
| Cancer3D | CLOCK(select the gene name) |
| Impact of mutations | [PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 601851 |
| Orphanet | |
| DisGeNET | CLOCK |
| Medgen | CLOCK |
| Genetic Testing Registry | CLOCK
|
| NextProt | O15516 [Medical] |
| TSGene | 9575 |
| GENETests | CLOCK |
| Target Validation | CLOCK |
| Huge Navigator |
CLOCK [HugePedia] |
| snp3D : Map Gene to Disease | 9575 |
| BioCentury BCIQ | CLOCK |
| ClinGen | CLOCK |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 9575 |
| Chemical/Pharm GKB Gene | PA26609 |
| Clinical trial | CLOCK |
| Miscellaneous |
|---|
| canSAR (ICR) | CLOCK (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 216 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | CLOCK |
| EVEX | CLOCK |
| GoPubMed | CLOCK |
| iHOP | CLOCK |
