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CLOCK (clock circadian regulator)

Identity

Alias_namesclock (mouse) homolog
clock homolog (mouse)
Alias_symbol (synonym)KIAA0334
KAT13D
bHLHe8
Other alias
HGNC (Hugo) CLOCK
LocusID (NCBI) 9575
Atlas_Id 50468
Location 4q12  [Link to chromosome band 4q12]
Location_base_pair Starts at 55427901 and ends at 55545932 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CLOCK (4q12) / CLOCK (4q12)CLOCK (4q12) / NMU (4q12)CLOCK (4q12) / PDGFRA (4q12)
CLOCK (4q12) / PHF21A (11p11.2)CLOCK (4q12) / SRD5A3 (4q12)CLOCK (4q12) / UGT2A3 (4q13.2)
CLOCK 4q12 / NMU 4q12CLOCK 4q12 / PDGFRA 4q12CLOCK 4q12 / PHF21A 11p11.2
CLOCK 4q12 / SRD5A3 4q12CLOCK 4q12 / UGT2A3 4q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CLOCK   2082
Cards
Entrez_Gene (NCBI)CLOCK  9575  clock circadian regulator
AliasesKAT13D; bHLHe8
GeneCards (Weizmann)CLOCK
Ensembl hg19 (Hinxton)ENSG00000134852 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134852 [Gene_View]  chr4:55427901-55545932 [Contig_View]  CLOCK [Vega]
ICGC DataPortalENSG00000134852
TCGA cBioPortalCLOCK
AceView (NCBI)CLOCK
Genatlas (Paris)CLOCK
WikiGenes9575
SOURCE (Princeton)CLOCK
Genetics Home Reference (NIH)CLOCK
Genomic and cartography
GoldenPath hg38 (UCSC)CLOCK  -     chr4:55427901-55545932 -  4q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CLOCK  -     4q12   [Description]    (hg19-Feb_2009)
EnsemblCLOCK - 4q12 [CytoView hg19]  CLOCK - 4q12 [CytoView hg38]
Mapping of homologs : NCBICLOCK [Mapview hg19]  CLOCK [Mapview hg38]
OMIM601851   
Gene and transcription
Genbank (Entrez)AB002332 AB005535 AF011568 AK096319 AK124437
RefSeq transcript (Entrez)NM_001267843 NM_004898
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CLOCK
Cluster EST : UnigeneHs.689578 [ NCBI ]
CGAP (NCI)Hs.689578
Alternative Splicing GalleryENSG00000134852
Gene ExpressionCLOCK [ NCBI-GEO ]   CLOCK [ EBI - ARRAY_EXPRESS ]   CLOCK [ SEEK ]   CLOCK [ MEM ]
Gene Expression Viewer (FireBrowse)CLOCK [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9575
GTEX Portal (Tissue expression)CLOCK
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15516   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15516  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15516
Splice isoforms : SwissVarO15516
Catalytic activity : Enzyme2.3.1.48 [ Enzyme-Expasy ]   2.3.1.482.3.1.48 [ IntEnz-EBI ]   2.3.1.48 [ BRENDA ]   2.3.1.48 [ KEGG ]   
PhosPhoSitePlusO15516
Domaine pattern : Prosite (Expaxy)BHLH (PS50888)    PAS (PS50112)   
Domains : Interpro (EBI)bHLH_dom    Nuc_translocat    PAC    PAS    PAS_fold   
Domain families : Pfam (Sanger)HLH (PF00010)    PAS (PF00989)   
Domain families : Pfam (NCBI)pfam00010    pfam00989   
Domain families : Smart (EMBL)HLH (SM00353)  PAC (SM00086)  PAS (SM00091)  
Conserved Domain (NCBI)CLOCK
DMDM Disease mutations9575
Blocks (Seattle)CLOCK
PDB (SRS)4H10   
PDB (PDBSum)4H10   
PDB (IMB)4H10   
PDB (RSDB)4H10   
Structural Biology KnowledgeBase4H10   
SCOP (Structural Classification of Proteins)4H10   
CATH (Classification of proteins structures)4H10   
SuperfamilyO15516
Human Protein AtlasENSG00000134852
Peptide AtlasO15516
HPRD03508
IPIIPI00007284   IPI00853422   
Protein Interaction databases
DIP (DOE-UCLA)O15516
IntAct (EBI)O15516
FunCoupENSG00000134852
BioGRIDCLOCK
STRING (EMBL)CLOCK
ZODIACCLOCK
Ontologies - Pathways
QuickGOO15516
Ontology : AmiGODNA damage checkpoint  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding  core promoter sequence-specific DNA binding  core promoter binding  transcriptional activator activity, RNA polymerase II transcription factor binding  DNA binding  transcription factor activity, sequence-specific DNA binding  histone acetyltransferase activity  protein binding  nucleus  nucleoplasm  nucleoplasm  transcription factor complex  chromosome  regulation of transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  signal transduction  spermatogenesis  circadian rhythm  photoperiodism  histone acetylation  chromatin DNA binding  circadian regulation of gene expression  circadian regulation of gene expression  circadian regulation of gene expression  chromatoid body  regulation of hair cycle  proteasome-mediated ubiquitin-dependent protein catabolic process  intracellular membrane-bounded organelle  sequence-specific DNA binding  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  protein dimerization activity  positive regulation of inflammatory response  regulation of insulin secretion  positive regulation of NF-kappaB transcription factor activity  response to redox state  E-box binding  cellular response to ionizing radiation  regulation of type B pancreatic cell development  negative regulation of glucocorticoid receptor signaling pathway  
Ontology : EGO-EBIDNA damage checkpoint  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding  core promoter sequence-specific DNA binding  core promoter binding  transcriptional activator activity, RNA polymerase II transcription factor binding  DNA binding  transcription factor activity, sequence-specific DNA binding  histone acetyltransferase activity  protein binding  nucleus  nucleoplasm  nucleoplasm  transcription factor complex  chromosome  regulation of transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  signal transduction  spermatogenesis  circadian rhythm  photoperiodism  histone acetylation  chromatin DNA binding  circadian regulation of gene expression  circadian regulation of gene expression  circadian regulation of gene expression  chromatoid body  regulation of hair cycle  proteasome-mediated ubiquitin-dependent protein catabolic process  intracellular membrane-bounded organelle  sequence-specific DNA binding  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  protein dimerization activity  positive regulation of inflammatory response  regulation of insulin secretion  positive regulation of NF-kappaB transcription factor activity  response to redox state  E-box binding  cellular response to ionizing radiation  regulation of type B pancreatic cell development  negative regulation of glucocorticoid receptor signaling pathway  
Pathways : BIOCARTACircadian Rhythms [Genes]   
Pathways : KEGGCircadian rhythm    Dopaminergic synapse    Herpes simplex infection   
NDEx NetworkCLOCK
Atlas of Cancer Signalling NetworkCLOCK
Wikipedia pathwaysCLOCK
Orthology - Evolution
OrthoDB9575
GeneTree (enSembl)ENSG00000134852
Phylogenetic Trees/Animal Genes : TreeFamCLOCK
HOVERGENO15516
HOGENOMO15516
Homologs : HomoloGeneCLOCK
Homology/Alignments : Family Browser (UCSC)CLOCK
Gene fusions - Rearrangements
Fusion : MitelmanCLOCK/PHF21A [4q12/11p11.2]  
Fusion : MitelmanCLOCK/UGT2A3 [4q12/4q13.2]  [t(4;4)(q12;q13)]  
Fusion: TCGACLOCK 4q12 NMU 4q12 LUAD
Fusion: TCGACLOCK 4q12 PDGFRA 4q12 LUAD
Fusion: TCGACLOCK 4q12 PHF21A 11p11.2 LUAD
Fusion: TCGACLOCK 4q12 SRD5A3 4q12 LUSC
Fusion: TCGACLOCK 4q12 UGT2A3 4q13.2 BLCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCLOCK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CLOCK
dbVarCLOCK
ClinVarCLOCK
1000_GenomesCLOCK 
Exome Variant ServerCLOCK
ExAC (Exome Aggregation Consortium)CLOCK (select the gene name)
Genetic variants : HAPMAP9575
Genomic Variants (DGV)CLOCK [DGVbeta]
DECIPHERCLOCK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCLOCK 
Mutations
ICGC Data PortalCLOCK 
TCGA Data PortalCLOCK 
Broad Tumor PortalCLOCK
OASIS PortalCLOCK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCLOCK  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCLOCK
intOGen PortalCLOCK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CLOCK
DgiDB (Drug Gene Interaction Database)CLOCK
DoCM (Curated mutations)CLOCK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CLOCK (select a term)
intoGenCLOCK
Cancer3DCLOCK(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601851   
Orphanet
MedgenCLOCK
Genetic Testing Registry CLOCK
NextProtO15516 [Medical]
TSGene9575
GENETestsCLOCK
Target ValidationCLOCK
Huge Navigator CLOCK [HugePedia]
snp3D : Map Gene to Disease9575
BioCentury BCIQCLOCK
ClinGenCLOCK
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9575
Chemical/Pharm GKB GenePA26609
Clinical trialCLOCK
Miscellaneous
canSAR (ICR)CLOCK (select the gene name)
Probes
Litterature
PubMed203 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCLOCK
EVEXCLOCK
GoPubMedCLOCK
iHOPCLOCK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:28:47 CEST 2017

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