| Nomenclature |
|---|
| HGNC (Hugo) | CLOCK 2082 |
| Cards |
|---|
| Entrez_Gene (NCBI) | CLOCK clock circadian regulator |
| Aliases | KAT13D; bHLHe8 |
| GeneCards (Weizmann) | CLOCK |
| Ensembl hg19 (Hinxton) | ENSG00000134852 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000134852 [Gene_View] ENSG00000134852 [Sequence] chr4:55427903-55546909 [Contig_View] CLOCK [Vega] |
| ICGC DataPortal | ENSG00000134852 |
| TCGA cBioPortal | CLOCK |
| AceView (NCBI) | CLOCK |
| Genatlas (Paris) | CLOCK |
| SOURCE (Princeton) | CLOCK |
| Genetics Home Reference (NIH) | CLOCK |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | CLOCK - chr4:55427903-55546909 - 4q12 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | CLOCK - 4q12 [Description] (hg19-Feb_2009) |
| GoldenPath | CLOCK - 4q12 [CytoView hg19] CLOCK - 4q12 [CytoView hg38] |
| ImmunoBase | ENSG00000134852 |
| Genome Data Viewer NCBI | CLOCK [Mapview hg19] |
| OMIM | 601851 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AB002332 AB005535 AF011568 AK096319 AK124437 |
| RefSeq transcript (Entrez) | NM_001267843 NM_004898 |
| Consensus coding sequences : CCDS (NCBI) | CLOCK |
| Gene Expression | CLOCK [ NCBI-GEO ] CLOCK [ EBI - ARRAY_EXPRESS ]
CLOCK [ SEEK ] CLOCK [ MEM ] |
| Gene Expression Viewer (FireBrowse) | CLOCK [ Firebrowse - Broad ] |
| Genevisible | Expression of CLOCK in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 9575 |
| GTEX Portal (Tissue expression) | CLOCK |
| Human Protein Atlas | ENSG00000134852-CLOCK [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | O15516 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | O15516 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | O15516 |
| Catalytic activity : Enzyme | 2.3.1.48 [ Enzyme-Expasy ] 2.3.1.482.3.1.48 [ IntEnz-EBI ] 2.3.1.48 [ BRENDA ] 2.3.1.48 [ KEGG ] [ MEROPS ] |
| PhosPhoSitePlus | O15516 |
| Domaine pattern : Prosite (Expaxy) | BHLH (PS50888) PAS (PS50112) |
| Domains : Interpro (EBI) | bHLH_dom HLH_DNA-bd_sf Nuc_translocat PAC PAS PAS-like_dom_sf PAS_fold |
| Domain families : Pfam (Sanger) | HLH (PF00010) PAS (PF00989) |
| Domain families : Pfam (NCBI) | pfam00010 pfam00989 |
| Domain families : Smart (EMBL) | HLH (SM00353) PAC (SM00086) PAS (SM00091) |
| Conserved Domain (NCBI) | CLOCK |
| PDB (RSDB) | 4H10 6QPJ |
| PDB Europe | 4H10 6QPJ |
| PDB (PDBSum) | 4H10 6QPJ |
| PDB (IMB) | 4H10 6QPJ |
| Structural Biology KnowledgeBase | 4H10 6QPJ |
| SCOP (Structural Classification of Proteins) | 4H10 6QPJ |
| CATH (Classification of proteins structures) | 4H10 6QPJ |
| Superfamily | O15516 |
| AlphaFold pdb e-kb | O15516 |
| Human Protein Atlas [tissue] | ENSG00000134852-CLOCK [tissue] |
| HPRD | 03508 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | O15516 |
| IntAct (EBI) | O15516 |
| BioGRID | CLOCK |
| STRING (EMBL) | CLOCK |
| ZODIAC | CLOCK |
| Ontologies - Pathways |
|---|
| QuickGO | O15516 |
| Ontology : AmiGO | DNA damage checkpoint signaling chromatin RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity histone acetyltransferase activity protein binding nucleus nucleoplasm nucleoplasm transcription regulator complex chromosome cytosol regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II protein acetylation signal transduction spermatogenesis circadian rhythm photoperiodism histone acetylation chromatin DNA binding circadian regulation of gene expression circadian regulation of gene expression circadian regulation of gene expression circadian regulation of gene expression chromatoid body regulation of hair cycle regulation of circadian rhythm positive regulation of circadian rhythm proteasome-mediated ubiquitin-dependent protein catabolic process intracellular membrane-bounded organelle sequence-specific DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II protein dimerization activity positive regulation of inflammatory response regulation of insulin secretion positive regulation of NF-kappaB transcription factor activity response to redox state E-box binding E-box binding cellular response to ionizing radiation CLOCK-BMAL transcription complex CLOCK-BMAL transcription complex sequence-specific double-stranded DNA binding regulation of type B pancreatic cell development negative regulation of glucocorticoid receptor signaling pathway |
| Ontology : EGO-EBI | DNA damage checkpoint signaling chromatin RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity histone acetyltransferase activity protein binding nucleus nucleoplasm nucleoplasm transcription regulator complex chromosome cytosol regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II protein acetylation signal transduction spermatogenesis circadian rhythm photoperiodism histone acetylation chromatin DNA binding circadian regulation of gene expression circadian regulation of gene expression circadian regulation of gene expression circadian regulation of gene expression chromatoid body regulation of hair cycle regulation of circadian rhythm positive regulation of circadian rhythm proteasome-mediated ubiquitin-dependent protein catabolic process intracellular membrane-bounded organelle sequence-specific DNA binding negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II protein dimerization activity positive regulation of inflammatory response regulation of insulin secretion positive regulation of NF-kappaB transcription factor activity response to redox state E-box binding E-box binding cellular response to ionizing radiation CLOCK-BMAL transcription complex CLOCK-BMAL transcription complex sequence-specific double-stranded DNA binding regulation of type B pancreatic cell development negative regulation of glucocorticoid receptor signaling pathway |
| Pathways : BIOCARTA | BIOCARTA_CIRCADIANPATHWAY |
| Pathways : KEGG | KEGG_CIRCADIAN_RHYTHM_MAMMAL |
| NDEx Network | CLOCK |
| Atlas of Cancer Signalling Network | CLOCK |
| Wikipedia pathways | CLOCK |
| Orthology - Evolution |
|---|
| OrthoDB | 9575 |
| GeneTree (enSembl) | ENSG00000134852 |
| Phylogenetic Trees/Animal Genes : TreeFam | CLOCK |
| Homologs : HomoloGene | CLOCK |
| Homology/Alignments : Family Browser (UCSC) | CLOCK |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | CLOCK::PHF21A [4q12/11p11.2] |
| Fusion : Mitelman | CLOCK::UGT2A3 [4q12/4q13.2] |
| Fusion : Quiver | CLOCK |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | CLOCK [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | CLOCK |
| dbVar | CLOCK |
| ClinVar | CLOCK |
| Monarch | CLOCK |
| 1000_Genomes | CLOCK |
| Exome Variant Server | CLOCK |
| GNOMAD Browser | ENSG00000134852 |
| Varsome Browser | CLOCK |
| ACMG | CLOCK variants |
| Varity | O15516 |
| Genomic Variants (DGV) | CLOCK [DGVbeta] |
| DECIPHER | CLOCK [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | CLOCK |
| Mutations |
|---|
| ICGC Data Portal | CLOCK |
| TCGA Data Portal | CLOCK |
| Broad Tumor Portal | CLOCK |
| OASIS Portal | CLOCK [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | CLOCK [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | CLOCK |
| Mutations and Diseases : HGMD | CLOCK |
| intOGen Portal | CLOCK |
| LOVD (Leiden Open Variation Database) | [gene] [transcripts] [variants] |
| BioMuta | CLOCK |
| DgiDB (Drug Gene Interaction Database) | CLOCK |
| DoCM (Curated mutations) | CLOCK |
| CIViC (Clinical Interpretations of Variants in Cancer) | CLOCK |
| Cancer3D | CLOCK |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 601851 |
| Orphanet | |
| DisGeNET | CLOCK |
| Medgen | CLOCK |
| Genetic Testing Registry | CLOCK
|
| NextProt | O15516 [Medical] |
| GENETests | CLOCK |
| Target Validation | CLOCK |
| Huge Navigator |
CLOCK [HugePedia] |
| ClinGen | CLOCK |
| Clinical trials, drugs, therapy |
|---|
| MyCancerGenome | CLOCK |
| Protein Interactions : CTD | CLOCK |
| Pharm GKB Gene | PA26609 |
| Pharos | O15516 |
| Clinical trial | CLOCK |
| Miscellaneous |
|---|
| canSAR (ICR) | CLOCK |
| Harmonizome | CLOCK |
| ARCHS4 | CLOCK |
| DataMed Index | CLOCK |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 283 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| EVEX | CLOCK |
