CLOCK (clock circadian regulator)

2008-12-01  

Identity

HGNC
LOCATION
4q12
LOCUSID
ALIAS
KAT13D,bHLHe8
FUSION GENES

Other Information

Locus ID:

NCBI: 9575
MIM: 601851
HGNC: 2082
Ensembl: ENSG00000134852

Variants:

dbSNP: 9575
ClinVar: 9575
TCGA: ENSG00000134852
COSMIC: CLOCK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134852ENST00000309964O15516
ENSG00000134852ENST00000381322O15516
ENSG00000134852ENST00000435527C9JK03
ENSG00000134852ENST00000513440O15516

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Circadian rhythmKEGGko04710
Circadian rhythmKEGGhsa04710
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
Circadian ClockREACTOMER-HSA-400253
BMAL1:CLOCK,NPAS2 activates circadian gene expressionREACTOMER-HSA-1368108
RORA activates gene expressionREACTOMER-HSA-1368082
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HATs acetylate histonesREACTOMER-HSA-3214847

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443450AsthmaDiseaseClinicalAnnotationassociatedPD23508266
PA447199Bipolar DisorderDiseaseClinicalAnnotationassociatedPD21047205
PA448068salbutamolChemicalClinicalAnnotationassociatedPD23508266
PA450243lithiumChemicalClinicalAnnotationassociatedPD21047205

References

Pubmed IDYearTitleCitations
128413652003A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference.139
164744062006Feedback repression is required for mammalian circadian clock function.112
159172222005SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein.105
180713402008Association between polymorphisms in the Clock gene, obesity and the metabolic syndrome in man.95
180713402008Association between polymorphisms in the Clock gene, obesity and the metabolic syndrome in man.95
128970572003BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system.94
198745742009Genetical genomic determinants of alcohol consumption in rats and humans.93
200721162010Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder.91
165287482006Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorder.88
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85

Citation

Dessen P

CLOCK (clock circadian regulator)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50468/clock