Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CLP1 (cleavage and polyadenylation factor I subunit 1)

Identity

Alias_namesCLP1
Alias_symbol (synonym)HEAB
hClp1
Other alias
HGNC (Hugo) CLP1
LocusID (NCBI) 10978
Atlas_Id 40810
Location 11q12.1  [Link to chromosome band 11q12]
Location_base_pair Starts at 57425216 and ends at 57429337 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CLP1 (11q12.1) / KMT2A (11q23.3)CLP1 (11q12.1) / MLLT10 (10p12.31)KMT2A (11q23.3) / CLP1 (11q12.1)
MLLT10 (10p12.31) / CLP1 (11q12.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CLP1   16999
Cards
Entrez_Gene (NCBI)CLP1  10978  cleavage and polyadenylation factor I subunit 1
AliasesHEAB; hClp1
GeneCards (Weizmann)CLP1
Ensembl hg19 (Hinxton)ENSG00000172409 [Gene_View]  chr11:57425216-57429337 [Contig_View]  CLP1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000172409 [Gene_View]  chr11:57425216-57429337 [Contig_View]  CLP1 [Vega]
ICGC DataPortalENSG00000172409
TCGA cBioPortalCLP1
AceView (NCBI)CLP1
Genatlas (Paris)CLP1
WikiGenes10978
SOURCE (Princeton)CLP1
Genetics Home Reference (NIH)CLP1
Genomic and cartography
GoldenPath hg19 (UCSC)CLP1  -     chr11:57425216-57429337 +  11q12.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CLP1  -     11q12.1   [Description]    (hg38-Dec_2013)
EnsemblCLP1 - 11q12.1 [CytoView hg19]  CLP1 - 11q12.1 [CytoView hg38]
Mapping of homologs : NCBICLP1 [Mapview hg19]  CLP1 [Mapview hg38]
OMIM608757   615803   
Gene and transcription
Genbank (Entrez)AK300232 AK313007 BC000446 DA922553 U73524
RefSeq transcript (Entrez)NM_001142597 NM_006831
RefSeq genomic (Entrez)NC_000011 NC_018922 NG_034248 NT_167190 NW_004929380
Consensus coding sequences : CCDS (NCBI)CLP1
Cluster EST : UnigeneHs.523687 [ NCBI ]
CGAP (NCI)Hs.523687
Alternative Splicing GalleryENSG00000172409
Gene ExpressionCLP1 [ NCBI-GEO ]   CLP1 [ EBI - ARRAY_EXPRESS ]   CLP1 [ SEEK ]   CLP1 [ MEM ]
Gene Expression Viewer (FireBrowse)CLP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10978
GTEX Portal (Tissue expression)CLP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92989   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92989  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92989
Splice isoforms : SwissVarQ92989
PhosPhoSitePlusQ92989
Domains : Interpro (EBI)Clp1    Clp1_N    CLP1_P    P-loop_NTPase    Pre-mRNA_cleavage_Clp1   
Domain families : Pfam (Sanger)Clp1 (PF06807)    CLP1_N (PF16573)    CLP1_P (PF16575)   
Domain families : Pfam (NCBI)pfam06807    pfam16573    pfam16575   
Conserved Domain (NCBI)CLP1
DMDM Disease mutations10978
Blocks (Seattle)CLP1
SuperfamilyQ92989
Human Protein AtlasENSG00000172409
Peptide AtlasQ92989
HPRD16382
IPIIPI00024381   IPI00908312   IPI00980131   IPI00976424   IPI00981315   
Protein Interaction databases
DIP (DOE-UCLA)Q92989
IntAct (EBI)Q92989
FunCoupENSG00000172409
BioGRIDCLP1
STRING (EMBL)CLP1
ZODIACCLP1
Ontologies - Pathways
QuickGOQ92989
Ontology : AmiGOtRNA-intron endonuclease complex  mRNA splicing, via spliceosome  ATP binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  mRNA cleavage factor complex  termination of RNA polymerase II transcription  mRNA polyadenylation  mRNA cleavage  tRNA splicing, via endonucleolytic cleavage and ligation  tRNA splicing, via endonucleolytic cleavage and ligation  tRNA splicing, via endonucleolytic cleavage and ligation  phosphorylation  cerebellar cortex development  targeting of mRNA for destruction involved in RNA interference  mRNA 3'-end processing  siRNA loading onto RISC involved in RNA interference  ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity  polydeoxyribonucleotide kinase activity  ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity  ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity  
Ontology : EGO-EBItRNA-intron endonuclease complex  mRNA splicing, via spliceosome  ATP binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  mRNA cleavage factor complex  termination of RNA polymerase II transcription  mRNA polyadenylation  mRNA cleavage  tRNA splicing, via endonucleolytic cleavage and ligation  tRNA splicing, via endonucleolytic cleavage and ligation  tRNA splicing, via endonucleolytic cleavage and ligation  phosphorylation  cerebellar cortex development  targeting of mRNA for destruction involved in RNA interference  mRNA 3'-end processing  siRNA loading onto RISC involved in RNA interference  ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity  polydeoxyribonucleotide kinase activity  ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity  ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity  
Pathways : KEGGmRNA surveillance pathway   
NDEx NetworkCLP1
Atlas of Cancer Signalling NetworkCLP1
Wikipedia pathwaysCLP1
Orthology - Evolution
OrthoDB10978
GeneTree (enSembl)ENSG00000172409
Phylogenetic Trees/Animal Genes : TreeFamCLP1
HOVERGENQ92989
HOGENOMQ92989
Homologs : HomoloGeneCLP1
Homology/Alignments : Family Browser (UCSC)CLP1
Gene fusions - Rearrangements
Fusion : MitelmanMLLT10/CLP1 [10p12.31/11q12.1]  [ins(10;11)(p12;q23q12)]  [ins(10;11)(p12;q23q23)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCLP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CLP1
dbVarCLP1
ClinVarCLP1
1000_GenomesCLP1 
Exome Variant ServerCLP1
ExAC (Exome Aggregation Consortium)CLP1 (select the gene name)
Genetic variants : HAPMAP10978
Genomic Variants (DGV)CLP1 [DGVbeta]
DECIPHER (Syndromes)11:57425216-57429337  ENSG00000172409
CONAN: Copy Number AnalysisCLP1 
Mutations
ICGC Data PortalCLP1 
TCGA Data PortalCLP1 
Broad Tumor PortalCLP1
OASIS PortalCLP1 [ Somatic mutations - Copy number]
Cancer Gene: CensusCLP1 
Somatic Mutations in Cancer : COSMICCLP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCLP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CLP1
DgiDB (Drug Gene Interaction Database)CLP1
DoCM (Curated mutations)CLP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CLP1 (select a term)
intoGenCLP1
Cancer3DCLP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608757    615803   
Orphanet23012   
MedgenCLP1
Genetic Testing Registry CLP1
NextProtQ92989 [Medical]
TSGene10978
GENETestsCLP1
Huge Navigator CLP1 [HugePedia]
snp3D : Map Gene to Disease10978
BioCentury BCIQCLP1
ClinGenCLP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10978
Chemical/Pharm GKB GenePA162382477
Clinical trialCLP1
Miscellaneous
canSAR (ICR)CLP1 (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCLP1
EVEXCLP1
GoPubMedCLP1
iHOPCLP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:00:54 CET 2017

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