Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CLPB (caseinolytic mitochondrial matrix peptidase chaperone subunit B)

Identity

Alias (NCBI)ANKCLB
HSP78
MEGCANN
MGCA7
SKD3
HGNC (Hugo) CLPB
HGNC Alias symbHSP78
SKD3
FLJ13152
ANKCLB
HGNC Alias namesuppressor of potassium transport defect 3
 ankyrin-repeat containing bacterial clp fusion
HGNC Previous nameClpB caseinolytic peptidase B homolog (E. coli)
 ClpB homolog, mitochondrial AAA ATPase chaperonin
LocusID (NCBI) 81570
Atlas_Id 56169
Location 11q13.4  [Link to chromosome band 11q13]
Location_base_pair Starts at 72285496 and ends at 72434531 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CCDC90B (11q14.1)::CLPB (11q13.4)CLPB (11q13.4)::ARMC4 (10p12.1)CLPB (11q13.4)::C2CD3 (11q13.4)
CLPB (11q13.4)::CABP4 (11q13.2)CLPB (11q13.4)::HECA (6q24.1)CLPB (11q13.4)::MTUS2 (13q12.3)
CLPB (11q13.4)::STARD10 (11q13.4)LRP5 (11q13.2)::CLPB (11q13.4)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  Heavy chain diseases

External links

 

Nomenclature
HGNC (Hugo)CLPB   30664
Cards
Entrez_Gene (NCBI)CLPB    caseinolytic mitochondrial matrix peptidase chaperone subunit B
AliasesANKCLB; HSP78; MEGCANN; MGCA7; 
SKD3
GeneCards (Weizmann)CLPB
Ensembl hg19 (Hinxton)ENSG00000162129 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000162129 [Gene_View]  ENSG00000162129 [Sequence]  chr11:72285496-72434531 [Contig_View]  CLPB [Vega]
ICGC DataPortalENSG00000162129
TCGA cBioPortalCLPB
AceView (NCBI)CLPB
Genatlas (Paris)CLPB
SOURCE (Princeton)CLPB
Genetics Home Reference (NIH)CLPB
Genomic and cartography
GoldenPath hg38 (UCSC)CLPB  -     chr11:72285496-72434531 -  11q13.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CLPB  -     11q13.4   [Description]    (hg19-Feb_2009)
GoldenPathCLPB - 11q13.4 [CytoView hg19]  CLPB - 11q13.4 [CytoView hg38]
ImmunoBaseENSG00000162129
Genome Data Viewer NCBICLPB [Mapview hg19]  
OMIM616254   616271   
Gene and transcription
Genbank (Entrez)AK023214 AK302006 AK302069 AK302158 AL136909
RefSeq transcript (Entrez)NM_001258392 NM_001258393 NM_001258394 NM_030813
Consensus coding sequences : CCDS (NCBI)CLPB
Gene ExpressionCLPB [ NCBI-GEO ]   CLPB [ EBI - ARRAY_EXPRESS ]   CLPB [ SEEK ]   CLPB [ MEM ]
Gene Expression Viewer (FireBrowse)CLPB [ Firebrowse - Broad ]
GenevisibleExpression of CLPB in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)81570
GTEX Portal (Tissue expression)CLPB
Human Protein AtlasENSG00000162129-CLPB [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H078   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H078  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H078
PhosPhoSitePlusQ9H078
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)   
Domains : Interpro (EBI)AAA+_ATPase    Ankyrin_rpt    Ankyrin_rpt-contain_dom    Ankyrin_rpt-contain_sf    ATPase_AAA_core    Clp_ATPase_C    ClpA/B    P-loop_NTPase   
Domain families : Pfam (Sanger)AAA_2 (PF07724)    Ank_2 (PF12796)    ClpB_D2-small (PF10431)   
Domain families : Pfam (NCBI)pfam07724    pfam12796    pfam10431   
Domain families : Smart (EMBL)AAA (SM00382)  ANK (SM00248)  ClpB_D2-small (SM01086)  
Conserved Domain (NCBI)CLPB
SuperfamilyQ9H078
AlphaFold pdb e-kbQ9H078   
Human Protein Atlas [tissue]ENSG00000162129-CLPB [tissue]
HPRD11560
Protein Interaction databases
DIP (DOE-UCLA)Q9H078
IntAct (EBI)Q9H078
BioGRIDCLPB
STRING (EMBL)CLPB
ZODIACCLPB
Ontologies - Pathways
QuickGOQ9H078
Ontology : AmiGOmolecular_function  protein binding  ATP binding  cytoplasm  mitochondrion  mitochondrial intermembrane space  hydrolase activity  ATPase  cellular response to heat  cellular response to heat  RIG-I signaling pathway  antiviral innate immune response  
Ontology : EGO-EBImolecular_function  protein binding  ATP binding  cytoplasm  mitochondrion  mitochondrial intermembrane space  hydrolase activity  ATPase  cellular response to heat  cellular response to heat  RIG-I signaling pathway  antiviral innate immune response  
NDEx NetworkCLPB
Atlas of Cancer Signalling NetworkCLPB
Wikipedia pathwaysCLPB
Orthology - Evolution
OrthoDB81570
GeneTree (enSembl)ENSG00000162129
Phylogenetic Trees/Animal Genes : TreeFamCLPB
Homologs : HomoloGeneCLPB
Homology/Alignments : Family Browser (UCSC)CLPB
Gene fusions - Rearrangements
Fusion : QuiverCLPB
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCLPB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CLPB
dbVarCLPB
ClinVarCLPB
MonarchCLPB
1000_GenomesCLPB 
Exome Variant ServerCLPB
GNOMAD BrowserENSG00000162129
Varsome BrowserCLPB
ACMGCLPB variants
VarityQ9H078
Genomic Variants (DGV)CLPB [DGVbeta]
DECIPHERCLPB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCLPB 
Mutations
ICGC Data PortalCLPB 
TCGA Data PortalCLPB 
Broad Tumor PortalCLPB
OASIS PortalCLPB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCLPB  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCLPB
Mutations and Diseases : HGMDCLPB
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCLPB
DgiDB (Drug Gene Interaction Database)CLPB
DoCM (Curated mutations)CLPB
CIViC (Clinical Interpretations of Variants in Cancer)CLPB
Cancer3DCLPB
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616254    616271   
Orphanet23516   
DisGeNETCLPB
MedgenCLPB
Genetic Testing Registry CLPB
NextProtQ9H078 [Medical]
GENETestsCLPB
Target ValidationCLPB
Huge Navigator CLPB [HugePedia]
ClinGenCLPB
Clinical trials, drugs, therapy
MyCancerGenomeCLPB
Protein Interactions : CTDCLPB
Pharm GKB GenePA142672092
PharosQ9H078
Clinical trialCLPB
Miscellaneous
canSAR (ICR)CLPB
HarmonizomeCLPB
ARCHS4CLPB
DataMed IndexCLPB
Probes
Litterature
PubMed58 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCLPB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Jan 17 15:19:31 CET 2022
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