Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CLPB (caseinolytic mitochondrial matrix peptidase chaperone subunit B)

Identity

Alias_namesClpB caseinolytic peptidase B homolog (E. coli)
Alias_symbol (synonym)HSP78
SKD3
FLJ13152
ANKCLB
Other aliasMEGCANN
MGCA7
HGNC (Hugo) CLPB
LocusID (NCBI) 81570
Atlas_Id 56169
Location 11q13.4  [Link to chromosome band 11q13]
Location_base_pair Starts at 72285496 and ends at 72434531 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CCDC90B (11q14.1) / CLPB (11q13.4)CLPB (11q13.4) / ARMC4 (10p12.1)CLPB (11q13.4) / C2CD3 (11q13.4)
CLPB (11q13.4) / CABP4 (11q13.2)CLPB (11q13.4) / HECA (6q24.1)CLPB (11q13.4) / MTUS2 (13q12.3)
CLPB (11q13.4) / STARD10 (11q13.4)LRP5 (11q13.2) / CLPB (11q13.4)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 6 ]
  t(10;11)(p12;q13) CLPB/ARMC4
CLPB/C2CD3 (11q13)
CLPB/STARD10 (11q13)
LRP5/CLPB (11q13)
t(11;11)(q13;q14) CCDC90B/CLPB
t(11;13)(q13;q12) CLPB/MTUS2

External links

Nomenclature
HGNC (Hugo)CLPB   30664
Cards
Entrez_Gene (NCBI)CLPB  81570  caseinolytic mitochondrial matrix peptidase chaperone subunit B
AliasesANKCLB; HSP78; MEGCANN; MGCA7; 
SKD3
GeneCards (Weizmann)CLPB
Ensembl hg19 (Hinxton)ENSG00000162129 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000162129 [Gene_View]  ENSG00000162129 [Sequence]  chr11:72285496-72434531 [Contig_View]  CLPB [Vega]
ICGC DataPortalENSG00000162129
TCGA cBioPortalCLPB
AceView (NCBI)CLPB
Genatlas (Paris)CLPB
WikiGenes81570
SOURCE (Princeton)CLPB
Genetics Home Reference (NIH)CLPB
Genomic and cartography
GoldenPath hg38 (UCSC)CLPB  -     chr11:72285496-72434531 -  11q13.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CLPB  -     11q13.4   [Description]    (hg19-Feb_2009)
GoldenPathCLPB - 11q13.4 [CytoView hg19]  CLPB - 11q13.4 [CytoView hg38]
Genome Data Viewer NCBICLPB [Mapview hg19]  
OMIM616254   616271   
Gene and transcription
Genbank (Entrez)AK023214 AK302006 AK302069 AK302158 AL136909
RefSeq transcript (Entrez)NM_001258392 NM_001258393 NM_001258394 NM_030813
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CLPB
Alternative Splicing GalleryENSG00000162129
Gene ExpressionCLPB [ NCBI-GEO ]   CLPB [ EBI - ARRAY_EXPRESS ]   CLPB [ SEEK ]   CLPB [ MEM ]
Gene Expression Viewer (FireBrowse)CLPB [ Firebrowse - Broad ]
GenevisibleExpression of CLPB in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)81570
GTEX Portal (Tissue expression)CLPB
Human Protein AtlasENSG00000162129-CLPB [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H078   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H078  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H078
Splice isoforms : SwissVarQ9H078
PhosPhoSitePlusQ9H078
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)   
Domains : Interpro (EBI)AAA+_ATPase    Ankyrin_rpt    Ankyrin_rpt-contain_dom    Ankyrin_rpt-contain_sf    ATPase_AAA_core    Clp_ATPase_C    ClpA/B    P-loop_NTPase   
Domain families : Pfam (Sanger)AAA_2 (PF07724)    Ank_2 (PF12796)    ClpB_D2-small (PF10431)   
Domain families : Pfam (NCBI)pfam07724    pfam12796    pfam10431   
Domain families : Smart (EMBL)AAA (SM00382)  ANK (SM00248)  ClpB_D2-small (SM01086)  
Conserved Domain (NCBI)CLPB
DMDM Disease mutations81570
SuperfamilyQ9H078
Human Protein Atlas [tissue]ENSG00000162129-CLPB [tissue]
Peptide AtlasQ9H078
HPRD11560
IPIIPI00006615   IPI00216192   IPI00910365   IPI01014146   IPI01012708   IPI01011473   IPI01013741   IPI01012514   IPI01011041   IPI01012019   IPI01012522   
Protein Interaction databases
DIP (DOE-UCLA)Q9H078
IntAct (EBI)Q9H078
FunCoupENSG00000162129
BioGRIDCLPB
STRING (EMBL)CLPB
ZODIACCLPB
Ontologies - Pathways
QuickGOQ9H078
Ontology : AmiGOmolecular_function  protein binding  ATP binding  cellular_component  mitochondrion  ATPase activity  cellular response to heat  
Ontology : EGO-EBImolecular_function  protein binding  ATP binding  cellular_component  mitochondrion  ATPase activity  cellular response to heat  
NDEx NetworkCLPB
Atlas of Cancer Signalling NetworkCLPB
Wikipedia pathwaysCLPB
Orthology - Evolution
OrthoDB81570
GeneTree (enSembl)ENSG00000162129
Phylogenetic Trees/Animal Genes : TreeFamCLPB
HOGENOMQ9H078
Homologs : HomoloGeneCLPB
Homology/Alignments : Family Browser (UCSC)CLPB
Gene fusions - Rearrangements
Fusion : QuiverCLPB
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCLPB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CLPB
dbVarCLPB
ClinVarCLPB
1000_GenomesCLPB 
Exome Variant ServerCLPB
GNOMAD BrowserENSG00000162129
Varsome BrowserCLPB
Genetic variants : HAPMAP81570
Genomic Variants (DGV)CLPB [DGVbeta]
DECIPHERCLPB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCLPB 
Mutations
ICGC Data PortalCLPB 
TCGA Data PortalCLPB 
Broad Tumor PortalCLPB
OASIS PortalCLPB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCLPB  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCLPB
Mutations and Diseases : HGMDCLPB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutaselect CLPB
DgiDB (Drug Gene Interaction Database)CLPB
DoCM (Curated mutations)CLPB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CLPB (select a term)
intoGenCLPB
Cancer3DCLPB (select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616254    616271   
Orphanet23516   
DisGeNETCLPB
MedgenCLPB
Genetic Testing Registry CLPB
NextProtQ9H078 [Medical]
TSGene81570
GENETestsCLPB
Open Targets GeneticsENSG00000162129  [validation]
snp3D : Map Gene to Disease81570
BioCentury BCIQCLPB
ClinGenCLPB
Clinical trials, drugs, therapy
Protein Interactions : CTD81570
Pharm GKB GenePA142672092
Clinical trialCLPB
Miscellaneous
canSAR (ICR)CLPB (select the gene name)
HarmonizomeCLPB
DataMed IndexCLPB
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCLPB
EVEXCLPB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Jul 11 19:43:57 CEST 2020
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