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CLPP (caseinolytic mitochondrial matrix peptidase proteolytic subunit)

Identity

Alias_namesproteolytic subunit
human
Other aliasDFNB81
PRLTS3
HGNC (Hugo) CLPP
LocusID (NCBI) 8192
Atlas_Id 46585
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 6361452 and ends at 6368904 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CLPP   2084
Cards
Entrez_Gene (NCBI)CLPP  8192  caseinolytic mitochondrial matrix peptidase proteolytic subunit
AliasesDFNB81; PRLTS3
GeneCards (Weizmann)CLPP
Ensembl hg19 (Hinxton)ENSG00000125656 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125656 [Gene_View]  chr19:6361452-6368904 [Contig_View]  CLPP [Vega]
ICGC DataPortalENSG00000125656
TCGA cBioPortalCLPP
AceView (NCBI)CLPP
Genatlas (Paris)CLPP
WikiGenes8192
SOURCE (Princeton)CLPP
Genetics Home Reference (NIH)CLPP
Genomic and cartography
GoldenPath hg38 (UCSC)CLPP  -     chr19:6361452-6368904 +  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CLPP  -     19p13.3   [Description]    (hg19-Feb_2009)
EnsemblCLPP - 19p13.3 [CytoView hg19]  CLPP - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBICLPP [Mapview hg19]  CLPP [Mapview hg38]
OMIM601119   614129   
Gene and transcription
Genbank (Entrez)AK311973 BC002956 BF339807 DQ895823 EF036491
RefSeq transcript (Entrez)NM_006012
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CLPP
Cluster EST : UnigeneHs.515092 [ NCBI ]
CGAP (NCI)Hs.515092
Alternative Splicing GalleryENSG00000125656
Gene ExpressionCLPP [ NCBI-GEO ]   CLPP [ EBI - ARRAY_EXPRESS ]   CLPP [ SEEK ]   CLPP [ MEM ]
Gene Expression Viewer (FireBrowse)CLPP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8192
GTEX Portal (Tissue expression)CLPP
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16740   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16740  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16740
Splice isoforms : SwissVarQ16740
Catalytic activity : Enzyme3.4.21.92 [ Enzyme-Expasy ]   3.4.21.923.4.21.92 [ IntEnz-EBI ]   3.4.21.92 [ BRENDA ]   3.4.21.92 [ KEGG ]   
PhosPhoSitePlusQ16740
Domaine pattern : Prosite (Expaxy)CLP_PROTEASE_HIS (PS00382)    CLP_PROTEASE_SER (PS00381)   
Domains : Interpro (EBI)ClpP    ClpP/crotonase-like_dom    ClpP/TepA    ClpP_His_AS    ClpP_Ser_AS   
Domain families : Pfam (Sanger)CLP_protease (PF00574)   
Domain families : Pfam (NCBI)pfam00574   
Conserved Domain (NCBI)CLPP
DMDM Disease mutations8192
Blocks (Seattle)CLPP
PDB (SRS)1TG6   
PDB (PDBSum)1TG6   
PDB (IMB)1TG6   
PDB (RSDB)1TG6   
Structural Biology KnowledgeBase1TG6   
SCOP (Structural Classification of Proteins)1TG6   
CATH (Classification of proteins structures)1TG6   
SuperfamilyQ16740
Human Protein AtlasENSG00000125656
Peptide AtlasQ16740
HPRD03074
IPIIPI00003870   
Protein Interaction databases
DIP (DOE-UCLA)Q16740
IntAct (EBI)Q16740
FunCoupENSG00000125656
BioGRIDCLPP
STRING (EMBL)CLPP
ZODIACCLPP
Ontologies - Pathways
QuickGOQ16740
Ontology : AmiGOserine-type endopeptidase activity  protein binding  mitochondrion  mitochondrial matrix  peptidase activity  endopeptidase Clp complex  identical protein binding  protein homooligomerization  proteolysis involved in cellular protein catabolic process  
Ontology : EGO-EBIserine-type endopeptidase activity  protein binding  mitochondrion  mitochondrial matrix  peptidase activity  endopeptidase Clp complex  identical protein binding  protein homooligomerization  proteolysis involved in cellular protein catabolic process  
NDEx NetworkCLPP
Atlas of Cancer Signalling NetworkCLPP
Wikipedia pathwaysCLPP
Orthology - Evolution
OrthoDB8192
GeneTree (enSembl)ENSG00000125656
Phylogenetic Trees/Animal Genes : TreeFamCLPP
HOVERGENQ16740
HOGENOMQ16740
Homologs : HomoloGeneCLPP
Homology/Alignments : Family Browser (UCSC)CLPP
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCLPP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CLPP
dbVarCLPP
ClinVarCLPP
1000_GenomesCLPP 
Exome Variant ServerCLPP
ExAC (Exome Aggregation Consortium)CLPP (select the gene name)
Genetic variants : HAPMAP8192
Genomic Variants (DGV)CLPP [DGVbeta]
DECIPHERCLPP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCLPP 
Mutations
ICGC Data PortalCLPP 
TCGA Data PortalCLPP 
Broad Tumor PortalCLPP
OASIS PortalCLPP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCLPP  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCLPP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch CLPP
DgiDB (Drug Gene Interaction Database)CLPP
DoCM (Curated mutations)CLPP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CLPP (select a term)
intoGenCLPP
Cancer3DCLPP(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601119    614129   
Orphanet2589   
MedgenCLPP
Genetic Testing Registry CLPP
NextProtQ16740 [Medical]
TSGene8192
GENETestsCLPP
Huge Navigator CLPP [HugePedia]
snp3D : Map Gene to Disease8192
BioCentury BCIQCLPP
ClinGenCLPP
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8192
Chemical/Pharm GKB GenePA26610
Clinical trialCLPP
Miscellaneous
canSAR (ICR)CLPP (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCLPP
EVEXCLPP
GoPubMedCLPP
iHOPCLPP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:10:59 CEST 2017

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