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CLVS1 (clavesin 1)

Identity

Alias_namesRLBP1L1
retinaldehyde binding protein 1-like 1
Alias_symbol (synonym)MGC34646
CRALBPL
C6orf212L
Other alias
HGNC (Hugo) CLVS1
LocusID (NCBI) 157807
Atlas_Id 51213
Location 8q12.2  [Link to chromosome band 8q12]
Location_base_pair Starts at 61287966 and ends at 61501645 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ASAP1 (8q24.21) / CLVS1 (8q12.3)ASB1 (2q37.3) / CLVS1 (8q12.3)NSMAF (8q12.1) / CLVS1 (8q12.3)
PVT1 (8q24.21) / CLVS1 (8q12.3)TRAM1 (8q13.3) / CLVS1 (8q12.3)ASAP1 8q24.21 / CLVS1 8q12.3
ASB1 2q37.3 / CLVS1 8q12.3NSMAF 8q12.1 / CLVS1 8q12.3TRAM1 8q13.3 / CLVS1 8q12.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Small Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)CLVS1   23139
Cards
Entrez_Gene (NCBI)CLVS1  157807  clavesin 1
AliasesC6orf212L; CRALBPL; RLBP1L1
GeneCards (Weizmann)CLVS1
Ensembl hg19 (Hinxton)ENSG00000177182 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000177182 [Gene_View]  chr8:61287966-61501645 [Contig_View]  CLVS1 [Vega]
ICGC DataPortalENSG00000177182
TCGA cBioPortalCLVS1
AceView (NCBI)CLVS1
Genatlas (Paris)CLVS1
WikiGenes157807
SOURCE (Princeton)CLVS1
Genetics Home Reference (NIH)CLVS1
Genomic and cartography
GoldenPath hg38 (UCSC)CLVS1  -     chr8:61287966-61501645 +  8q12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CLVS1  -     8q12.2   [Description]    (hg19-Feb_2009)
EnsemblCLVS1 - 8q12.2 [CytoView hg19]  CLVS1 - 8q12.2 [CytoView hg38]
Mapping of homologs : NCBICLVS1 [Mapview hg19]  CLVS1 [Mapview hg38]
OMIM611292   
Gene and transcription
Genbank (Entrez)AF445194 AK091641 AK094567 AK125153 AK313040
RefSeq transcript (Entrez)NM_173519
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CLVS1
Cluster EST : UnigeneHs.591874 [ NCBI ]
CGAP (NCI)Hs.591874
Alternative Splicing GalleryENSG00000177182
Gene ExpressionCLVS1 [ NCBI-GEO ]   CLVS1 [ EBI - ARRAY_EXPRESS ]   CLVS1 [ SEEK ]   CLVS1 [ MEM ]
Gene Expression Viewer (FireBrowse)CLVS1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)157807
GTEX Portal (Tissue expression)CLVS1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IUQ0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IUQ0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IUQ0
Splice isoforms : SwissVarQ8IUQ0
PhosPhoSitePlusQ8IUQ0
Domaine pattern : Prosite (Expaxy)CRAL_TRIO (PS50191)   
Domains : Interpro (EBI)Clavesin-1    CRAL-bd_toc_tran    CRAL-TRIO_dom    CRAL/TRIO_N_dom   
Domain families : Pfam (Sanger)CRAL_TRIO (PF00650)    CRAL_TRIO_N (PF03765)   
Domain families : Pfam (NCBI)pfam00650    pfam03765   
Domain families : Smart (EMBL)CRAL_TRIO_N (SM01100)  SEC14 (SM00516)  
Conserved Domain (NCBI)CLVS1
DMDM Disease mutations157807
Blocks (Seattle)CLVS1
SuperfamilyQ8IUQ0
Human Protein AtlasENSG00000177182
Peptide AtlasQ8IUQ0
HPRD14581
IPIIPI00292661   IPI00385813   IPI00974192   IPI00795988   IPI01011956   IPI00975817   
Protein Interaction databases
DIP (DOE-UCLA)Q8IUQ0
IntAct (EBI)Q8IUQ0
FunCoupENSG00000177182
BioGRIDCLVS1
STRING (EMBL)CLVS1
ZODIACCLVS1
Ontologies - Pathways
QuickGOQ8IUQ0
Ontology : AmiGOtransporter activity  endosome  trans-Golgi network  transport  lysosome organization  clathrin-coated vesicle  clathrin-coated endocytic vesicle membrane  early endosome membrane  trans-Golgi network membrane  phosphatidylinositol-3,5-bisphosphate binding  
Ontology : EGO-EBItransporter activity  endosome  trans-Golgi network  transport  lysosome organization  clathrin-coated vesicle  clathrin-coated endocytic vesicle membrane  early endosome membrane  trans-Golgi network membrane  phosphatidylinositol-3,5-bisphosphate binding  
NDEx NetworkCLVS1
Atlas of Cancer Signalling NetworkCLVS1
Wikipedia pathwaysCLVS1
Orthology - Evolution
OrthoDB157807
GeneTree (enSembl)ENSG00000177182
Phylogenetic Trees/Animal Genes : TreeFamCLVS1
HOVERGENQ8IUQ0
HOGENOMQ8IUQ0
Homologs : HomoloGeneCLVS1
Homology/Alignments : Family Browser (UCSC)CLVS1
Gene fusions - Rearrangements
Fusion : MitelmanASAP1/CLVS1 [8q24.21/8q12.3]  [t(8;8)(q12;q24)]  
Fusion : MitelmanASB1/CLVS1 [2q37.3/8q12.3]  [t(2;8)(q37;q12)]  
Fusion : MitelmanNSMAF/CLVS1 [8q12.1/8q12.3]  [t(8;8)(q12;q12)]  
Fusion : MitelmanPVT1/CLVS1 [8q24.21/8q12.3]  [t(8;8)(q12;q24)]  
Fusion : MitelmanTRAM1/CLVS1 [8q13.3/8q12.3]  [t(8;8)(q12;q13)]  
Fusion: TCGAASAP1 8q24.21 CLVS1 8q12.3 BRCA
Fusion: TCGAASB1 2q37.3 CLVS1 8q12.3 KIRC
Fusion: TCGANSMAF 8q12.1 CLVS1 8q12.3 PRAD
Fusion: TCGATRAM1 8q13.3 CLVS1 8q12.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCLVS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CLVS1
dbVarCLVS1
ClinVarCLVS1
1000_GenomesCLVS1 
Exome Variant ServerCLVS1
ExAC (Exome Aggregation Consortium)CLVS1 (select the gene name)
Genetic variants : HAPMAP157807
Genomic Variants (DGV)CLVS1 [DGVbeta]
DECIPHERCLVS1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCLVS1 
Mutations
ICGC Data PortalCLVS1 
TCGA Data PortalCLVS1 
Broad Tumor PortalCLVS1
OASIS PortalCLVS1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCLVS1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCLVS1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CLVS1
DgiDB (Drug Gene Interaction Database)CLVS1
DoCM (Curated mutations)CLVS1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CLVS1 (select a term)
intoGenCLVS1
Cancer3DCLVS1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611292   
Orphanet
MedgenCLVS1
Genetic Testing Registry CLVS1
NextProtQ8IUQ0 [Medical]
TSGene157807
GENETestsCLVS1
Target ValidationCLVS1
Huge Navigator CLVS1 [HugePedia]
snp3D : Map Gene to Disease157807
BioCentury BCIQCLVS1
ClinGenCLVS1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD157807
Chemical/Pharm GKB GenePA165585423
Clinical trialCLVS1
Miscellaneous
canSAR (ICR)CLVS1 (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCLVS1
EVEXCLVS1
GoPubMedCLVS1
iHOPCLVS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 19:02:54 CEST 2017

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