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CLVS2 (clavesin 2)

Identity

Alias_namesC6orf212
C6orf213
RLBP1L2
chromosome 6 open reading frame 212
chromosome 6 open reading frame 213
retinaldehyde binding protein 1-like 2
Alias_symbol (synonym)bA160A10.4
Other alias
HGNC (Hugo) CLVS2
LocusID (NCBI) 134829
Atlas_Id 61915
Location 6q22.31  [Link to chromosome band 6q22]
Location_base_pair Starts at 122995971 and ends at 123072919 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C3orf58 (3q24) / CLVS2 (6q22.31)MAP3K5 (6q23.3) / CLVS2 (6q22.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;6)(q22;q23) MAP3K5/CLVS2


External links

Nomenclature
HGNC (Hugo)CLVS2   23046
Cards
Entrez_Gene (NCBI)CLVS2  134829  clavesin 2
AliasesC6orf212; C6orf213; RLBP1L2; bA160A10.4
GeneCards (Weizmann)CLVS2
Ensembl hg19 (Hinxton)ENSG00000146352 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000146352 [Gene_View]  ENSG00000146352 [Sequence]  chr6:122995971-123072919 [Contig_View]  CLVS2 [Vega]
ICGC DataPortalENSG00000146352
TCGA cBioPortalCLVS2
AceView (NCBI)CLVS2
Genatlas (Paris)CLVS2
WikiGenes134829
SOURCE (Princeton)CLVS2
Genetics Home Reference (NIH)CLVS2
Genomic and cartography
GoldenPath hg38 (UCSC)CLVS2  -     chr6:122995971-123072919 +  6q22.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CLVS2  -     6q22.31   [Description]    (hg19-Feb_2009)
EnsemblCLVS2 - 6q22.31 [CytoView hg19]  CLVS2 - 6q22.31 [CytoView hg38]
Mapping of homologs : NCBICLVS2 [Mapview hg19]  CLVS2 [Mapview hg38]
OMIM616945   
Gene and transcription
Genbank (Entrez)AK055705 AK095527 AK295158 BC101376 BC101377
RefSeq transcript (Entrez)NM_001010852
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CLVS2
Cluster EST : UnigeneHs.486362 [ NCBI ]
CGAP (NCI)Hs.486362
Alternative Splicing GalleryENSG00000146352
Gene ExpressionCLVS2 [ NCBI-GEO ]   CLVS2 [ EBI - ARRAY_EXPRESS ]   CLVS2 [ SEEK ]   CLVS2 [ MEM ]
Gene Expression Viewer (FireBrowse)CLVS2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)134829
GTEX Portal (Tissue expression)CLVS2
Human Protein AtlasENSG00000146352-CLVS2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5SYC1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5SYC1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5SYC1
Splice isoforms : SwissVarQ5SYC1
PhosPhoSitePlusQ5SYC1
Domaine pattern : Prosite (Expaxy)CRAL_TRIO (PS50191)   
Domains : Interpro (EBI)Clavesin-2    CRAL-bd_toc_tran    CRAL-TRIO_dom    CRAL/TRIO_N_dom   
Domain families : Pfam (Sanger)CRAL_TRIO (PF00650)    CRAL_TRIO_N (PF03765)   
Domain families : Pfam (NCBI)pfam00650    pfam03765   
Domain families : Smart (EMBL)CRAL_TRIO_N (SM01100)  SEC14 (SM00516)  
Conserved Domain (NCBI)CLVS2
DMDM Disease mutations134829
Blocks (Seattle)CLVS2
SuperfamilyQ5SYC1
Human Protein Atlas [tissue]ENSG00000146352-CLVS2 [tissue]
Peptide AtlasQ5SYC1
HPRD16666
IPIIPI00646640   IPI00646147   
Protein Interaction databases
DIP (DOE-UCLA)Q5SYC1
IntAct (EBI)Q5SYC1
FunCoupENSG00000146352
BioGRIDCLVS2
STRING (EMBL)CLVS2
ZODIACCLVS2
Ontologies - Pathways
QuickGOQ5SYC1
Ontology : AmiGOtransporter activity  endosome  trans-Golgi network  transport  lysosome organization  clathrin-coated vesicle  clathrin-coated endocytic vesicle membrane  early endosome membrane  trans-Golgi network membrane  phosphatidylinositol-3,5-bisphosphate binding  
Ontology : EGO-EBItransporter activity  endosome  trans-Golgi network  transport  lysosome organization  clathrin-coated vesicle  clathrin-coated endocytic vesicle membrane  early endosome membrane  trans-Golgi network membrane  phosphatidylinositol-3,5-bisphosphate binding  
NDEx NetworkCLVS2
Atlas of Cancer Signalling NetworkCLVS2
Wikipedia pathwaysCLVS2
Orthology - Evolution
OrthoDB134829
GeneTree (enSembl)ENSG00000146352
Phylogenetic Trees/Animal Genes : TreeFamCLVS2
HOVERGENQ5SYC1
HOGENOMQ5SYC1
Homologs : HomoloGeneCLVS2
Homology/Alignments : Family Browser (UCSC)CLVS2
Gene fusions - Rearrangements
Fusion : QuiverCLVS2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCLVS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CLVS2
dbVarCLVS2
ClinVarCLVS2
1000_GenomesCLVS2 
Exome Variant ServerCLVS2
ExAC (Exome Aggregation Consortium)ENSG00000146352
GNOMAD BrowserENSG00000146352
Varsome BrowserCLVS2
Genetic variants : HAPMAP134829
Genomic Variants (DGV)CLVS2 [DGVbeta]
DECIPHERCLVS2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCLVS2 
Mutations
ICGC Data PortalCLVS2 
TCGA Data PortalCLVS2 
Broad Tumor PortalCLVS2
OASIS PortalCLVS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCLVS2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCLVS2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CLVS2
DgiDB (Drug Gene Interaction Database)CLVS2
DoCM (Curated mutations)CLVS2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CLVS2 (select a term)
intoGenCLVS2
Cancer3DCLVS2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616945   
Orphanet
DisGeNETCLVS2
MedgenCLVS2
Genetic Testing Registry CLVS2
NextProtQ5SYC1 [Medical]
TSGene134829
GENETestsCLVS2
Target ValidationCLVS2
Huge Navigator CLVS2 [HugePedia]
snp3D : Map Gene to Disease134829
BioCentury BCIQCLVS2
ClinGenCLVS2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD134829
Chemical/Pharm GKB GenePA165617885
Clinical trialCLVS2
Miscellaneous
canSAR (ICR)CLVS2 (select the gene name)
Probes
Litterature
PubMed5 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCLVS2
EVEXCLVS2
GoPubMedCLVS2
iHOPCLVS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Jul 30 13:40:56 CEST 2018

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