Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CMPK1 (cytidine/uridine monophosphate kinase 1)

Identity

Alias_namesCMPK
cytidylate kinase
cytidine monophosphate (UMP-CMP) kinase 1, cytosolic
Alias_symbol (synonym)UMP-CMPK
Other aliasCK
CMK
UMK
UMPK
HGNC (Hugo) CMPK1
LocusID (NCBI) 51727
Atlas_Id 52552
Location 1p33  [Link to chromosome band 1p33]
Location_base_pair Starts at 47333797 and ends at 47378839 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CMPK1 (1p33) / BANK1 (4q24)CMPK1 (1p33) / CMPK1 (1p33)CMPK1 (1p33) / NOP58 (2q33.1)
CMPK1 (1p33) / SH2D1B (1q23.3)CTSD (11p15.5) / CMPK1 (1p33)MORN1 (1p36.33) / CMPK1 (1p33)
MRPS22 (3q23) / CMPK1 (1p33)CMPK1 1p33 / SH2D1B 1q23.3MORN1 1p36.33 / CMPK1 1p33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(1;1)(p33;p36) MORN1/CMPK1
t(1;1)(p33;q23) CMPK1/SH2D1B


External links

Nomenclature
HGNC (Hugo)CMPK1   18170
Cards
Entrez_Gene (NCBI)CMPK1  51727  cytidine/uridine monophosphate kinase 1
AliasesCK; CMK; CMPK; UMK; 
UMP-CMPK; UMPK
GeneCards (Weizmann)CMPK1
Ensembl hg19 (Hinxton)ENSG00000162368 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000162368 [Gene_View]  ENSG00000162368 [Sequence]  chr1:47333797-47378839 [Contig_View]  CMPK1 [Vega]
ICGC DataPortalENSG00000162368
TCGA cBioPortalCMPK1
AceView (NCBI)CMPK1
Genatlas (Paris)CMPK1
WikiGenes51727
SOURCE (Princeton)CMPK1
Genetics Home Reference (NIH)CMPK1
Genomic and cartography
GoldenPath hg38 (UCSC)CMPK1  -     chr1:47333797-47378839 +  1p33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CMPK1  -     1p33   [Description]    (hg19-Feb_2009)
EnsemblCMPK1 - 1p33 [CytoView hg19]  CMPK1 - 1p33 [CytoView hg38]
Mapping of homologs : NCBICMPK1 [Mapview hg19]  CMPK1 [Mapview hg38]
OMIM191710   
Gene and transcription
Genbank (Entrez)AF070416 AF087865 AF110643 AF112216 AF259961
RefSeq transcript (Entrez)NM_001136140 NM_016308
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CMPK1
Cluster EST : UnigeneHs.745001 [ NCBI ]
CGAP (NCI)Hs.745001
Alternative Splicing GalleryENSG00000162368
Gene ExpressionCMPK1 [ NCBI-GEO ]   CMPK1 [ EBI - ARRAY_EXPRESS ]   CMPK1 [ SEEK ]   CMPK1 [ MEM ]
Gene Expression Viewer (FireBrowse)CMPK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51727
GTEX Portal (Tissue expression)CMPK1
Human Protein AtlasENSG00000162368-CMPK1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP30085   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP30085  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP30085
Splice isoforms : SwissVarP30085
PhosPhoSitePlusP30085
Domaine pattern : Prosite (Expaxy)ADENYLATE_KINASE (PS00113)   
Domains : Interpro (EBI)Adenylat/UMP-CMP_kin    Adenylat_kinase_CS    P-loop_NTPase    UMP_CMP_kinase   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)CMPK1
DMDM Disease mutations51727
Blocks (Seattle)CMPK1
PDB (SRS)1TEV   
PDB (PDBSum)1TEV   
PDB (IMB)1TEV   
PDB (RSDB)1TEV   
Structural Biology KnowledgeBase1TEV   
SCOP (Structural Classification of Proteins)1TEV   
CATH (Classification of proteins structures)1TEV   
SuperfamilyP30085
Human Protein Atlas [tissue]ENSG00000162368-CMPK1 [tissue]
Peptide AtlasP30085
HPRD18258
IPIIPI00908752   IPI00514049   IPI00219953   IPI00514929   IPI00909419   
Protein Interaction databases
DIP (DOE-UCLA)P30085
IntAct (EBI)P30085
FunCoupENSG00000162368
BioGRIDCMPK1
STRING (EMBL)CMPK1
ZODIACCMPK1
Ontologies - Pathways
QuickGOP30085
Ontology : AmiGOcytidylate kinase activity  nucleoside diphosphate kinase activity  uridine kinase activity  ATP binding  nucleus  nucleolus  cytoplasm  cytosol  nucleoside diphosphate phosphorylation  'de novo' pyrimidine nucleobase biosynthetic process  UMP biosynthetic process  uridylate kinase activity  nucleoside triphosphate biosynthetic process  pyrimidine ribonucleotide biosynthetic process  nucleobase-containing small molecule interconversion  nucleoside monophosphate phosphorylation  nucleoside monophosphate kinase activity  extracellular exosome  
Ontology : EGO-EBIcytidylate kinase activity  nucleoside diphosphate kinase activity  uridine kinase activity  ATP binding  nucleus  nucleolus  cytoplasm  cytosol  nucleoside diphosphate phosphorylation  'de novo' pyrimidine nucleobase biosynthetic process  UMP biosynthetic process  uridylate kinase activity  nucleoside triphosphate biosynthetic process  pyrimidine ribonucleotide biosynthetic process  nucleobase-containing small molecule interconversion  nucleoside monophosphate phosphorylation  nucleoside monophosphate kinase activity  extracellular exosome  
Pathways : KEGGPyrimidine metabolism   
NDEx NetworkCMPK1
Atlas of Cancer Signalling NetworkCMPK1
Wikipedia pathwaysCMPK1
Orthology - Evolution
OrthoDB51727
GeneTree (enSembl)ENSG00000162368
Phylogenetic Trees/Animal Genes : TreeFamCMPK1
HOVERGENP30085
HOGENOMP30085
Homologs : HomoloGeneCMPK1
Homology/Alignments : Family Browser (UCSC)CMPK1
Gene fusions - Rearrangements
Fusion : MitelmanCMPK1/SH2D1B [1p33/1q23.3]  
Fusion : MitelmanMORN1/CMPK1 [1p36.33/1p33]  [t(1;1)(p33;p36)]  
Fusion PortalCMPK1 1p33 SH2D1B 1q23.3 BRCA
Fusion PortalMORN1 1p36.33 CMPK1 1p33 BRCA
Fusion : QuiverCMPK1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCMPK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CMPK1
dbVarCMPK1
ClinVarCMPK1
1000_GenomesCMPK1 
Exome Variant ServerCMPK1
ExAC (Exome Aggregation Consortium)ENSG00000162368
GNOMAD BrowserENSG00000162368
Varsome BrowserCMPK1
Genetic variants : HAPMAP51727
Genomic Variants (DGV)CMPK1 [DGVbeta]
DECIPHERCMPK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCMPK1 
Mutations
ICGC Data PortalCMPK1 
TCGA Data PortalCMPK1 
Broad Tumor PortalCMPK1
OASIS PortalCMPK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCMPK1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCMPK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CMPK1
DgiDB (Drug Gene Interaction Database)CMPK1
DoCM (Curated mutations)CMPK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CMPK1 (select a term)
intoGenCMPK1
Cancer3DCMPK1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM191710   
Orphanet
DisGeNETCMPK1
MedgenCMPK1
Genetic Testing Registry CMPK1
NextProtP30085 [Medical]
TSGene51727
GENETestsCMPK1
Target ValidationCMPK1
Huge Navigator CMPK1 [HugePedia]
snp3D : Map Gene to Disease51727
BioCentury BCIQCMPK1
ClinGenCMPK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51727
Chemical/Pharm GKB GenePA162382539
Clinical trialCMPK1
Miscellaneous
canSAR (ICR)CMPK1 (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCMPK1
EVEXCMPK1
GoPubMedCMPK1
iHOPCMPK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 27 11:16:08 CEST 2018

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