CMTM3 (CKLF like MARVEL transmembrane domain containing 3)

2014-07-01  

Identity

HGNC
CMTM3
LOCATION
16q22.1
LOCUSID
123920
ALIAS
BNAS2,CKLFSF3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 123920
MIM: 607886
HGNC: 19174
Ensembl: ENSG00000140931

Variants:

dbSNP: 123920
ClinVar: 123920
TCGA: ENSG00000140931
COSMIC: CMTM3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140931ENST00000361909Q96MX0
ENSG00000140931ENST00000361909A0A024R6Y8
ENSG00000140931ENST00000424011Q96MX0
ENSG00000140931ENST00000424011A0A024R6Y8
ENSG00000140931ENST00000460097B3KQJ8
ENSG00000140931ENST00000562357H3BN06
ENSG00000140931ENST00000562707Q96MX0
ENSG00000140931ENST00000562707A0A024R6Y8
ENSG00000140931ENST00000563672H3BU39
ENSG00000140931ENST00000564060H3BUD5
ENSG00000140931ENST00000565003I3L3C2
ENSG00000140931ENST00000565666J3KSM1
ENSG00000140931ENST00000565922Q96MX0
ENSG00000140931ENST00000566121B3KQJ8
ENSG00000140931ENST00000566756J3KSR6
ENSG00000140931ENST00000567572Q96MX0
ENSG00000140931ENST00000567572A0A024R6Y8
ENSG00000140931ENST00000568477B3KQJ8

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
127821302003Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation.31
287825762017DNA methylation of CMTM3, SSTR2, and MDFI genes in colorectal cancer.16
271210552016Knockdown of CMTM3 promotes metastasis of gastric cancer via the STAT3/Twist1/EMT signaling pathway.12
239072922014CMTM3 is frequently reduced in clear cell renal cell carcinoma and exhibits tumor suppressor activities.10
278670152017CMTM3 decreases EGFR expression and EGF-mediated tumorigenicity by promoting Rab5 activity in gastric cancer.10
184027732008CMTM3 can affect the transcription activity of androgen receptor and inhibit the expression level of PSA in LNCaP cells.9
275219942016Elevated methylation of CMTM3 promoter in the male laryngeal squamous cell carcinoma patients.9
293452972018miR-135b-5p promotes gastric cancer progression by targeting CMTM3.9
241314722014CMTM3 inhibits cell migration and invasion and correlates with favorable prognosis in gastric cancer.8
284282202017CMTM3 (CKLF-Like Marvel Transmembrane Domain 3) Mediates Angiogenesis by Regulating Cell Surface Availability of VE-Cadherin in Endothelial Adherens Junctions.6

Citation

Dessen P

CMTM3 (CKLF like MARVEL transmembrane domain containing 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-07-01

Online version: http://atlasgeneticsoncology.org/gene/54080/cmtm3