Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CNKSR2 (connector enhancer of kinase suppressor of Ras 2)

Identity

Alias_symbol (synonym)KIAA0902
CNK2
KSR2
Other aliasMAGUIN
HGNC (Hugo) CNKSR2
LocusID (NCBI) 22866
Atlas_Id 61939
Location Xp22.12  [Link to chromosome band Xp22]
Location_base_pair Starts at 21374298 and ends at 21654695 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CNKSR2 (Xp22.12) / PIP5K1B (9q21.11)MBTPS2 (Xp22.12) / CNKSR2 (Xp22.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CNKSR2   19701
Cards
Entrez_Gene (NCBI)CNKSR2  22866  connector enhancer of kinase suppressor of Ras 2
AliasesCNK2; KSR2; MAGUIN
GeneCards (Weizmann)CNKSR2
Ensembl hg19 (Hinxton)ENSG00000149970 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000149970 [Gene_View]  chrX:21374298-21654695 [Contig_View]  CNKSR2 [Vega]
ICGC DataPortalENSG00000149970
TCGA cBioPortalCNKSR2
AceView (NCBI)CNKSR2
Genatlas (Paris)CNKSR2
WikiGenes22866
SOURCE (Princeton)CNKSR2
Genetics Home Reference (NIH)CNKSR2
Genomic and cartography
GoldenPath hg38 (UCSC)CNKSR2  -     chrX:21374298-21654695 +  Xp22.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CNKSR2  -     Xp22.12   [Description]    (hg19-Feb_2009)
EnsemblCNKSR2 - Xp22.12 [CytoView hg19]  CNKSR2 - Xp22.12 [CytoView hg38]
Mapping of homologs : NCBICNKSR2 [Mapview hg19]  CNKSR2 [Mapview hg38]
OMIM300724   
Gene and transcription
Genbank (Entrez)AB020709 AF418269 AF418270 AI817268 AK056549
RefSeq transcript (Entrez)NM_001168647 NM_001168648 NM_001168649 NM_001330770 NM_001330771 NM_001330772 NM_001330773 NM_014927
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CNKSR2
Cluster EST : UnigeneHs.555917 [ NCBI ]
CGAP (NCI)Hs.555917
Alternative Splicing GalleryENSG00000149970
Gene ExpressionCNKSR2 [ NCBI-GEO ]   CNKSR2 [ EBI - ARRAY_EXPRESS ]   CNKSR2 [ SEEK ]   CNKSR2 [ MEM ]
Gene Expression Viewer (FireBrowse)CNKSR2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)22866
GTEX Portal (Tissue expression)CNKSR2
Human Protein AtlasENSG00000149970-CNKSR2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WXI2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WXI2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WXI2
Splice isoforms : SwissVarQ8WXI2
PhosPhoSitePlusQ8WXI2
Domaine pattern : Prosite (Expaxy)CRIC (PS51290)    PDZ (PS50106)    PH_DOMAIN (PS50003)    SAM_DOMAIN (PS50105)   
Domains : Interpro (EBI)CNKSR2    CRIC_domain    PDZ    PH_dom-like    PH_domain    SAM    SAM/pointed   
Domain families : Pfam (Sanger)CRIC_ras_sig (PF10534)    DUF1170 (PF06663)    PDZ (PF00595)    PH (PF00169)    SAM_1 (PF00536)   
Domain families : Pfam (NCBI)pfam10534    pfam06663    pfam00595    pfam00169    pfam00536   
Domain families : Smart (EMBL)PDZ (SM00228)  PH (SM00233)  SAM (SM00454)  
Conserved Domain (NCBI)CNKSR2
DMDM Disease mutations22866
Blocks (Seattle)CNKSR2
PDB (SRS)2EAN    3BS5   
PDB (PDBSum)2EAN    3BS5   
PDB (IMB)2EAN    3BS5   
PDB (RSDB)2EAN    3BS5   
Structural Biology KnowledgeBase2EAN    3BS5   
SCOP (Structural Classification of Proteins)2EAN    3BS5   
CATH (Classification of proteins structures)2EAN    3BS5   
SuperfamilyQ8WXI2
Human Protein Atlas [tissue]ENSG00000149970-CNKSR2 [tissue]
Peptide AtlasQ8WXI2
HPRD06473
IPIIPI00435208   IPI00435209   IPI00939128   IPI00909333   
Protein Interaction databases
DIP (DOE-UCLA)Q8WXI2
IntAct (EBI)Q8WXI2
FunCoupENSG00000149970
BioGRIDCNKSR2
STRING (EMBL)CNKSR2
ZODIACCNKSR2
Ontologies - Pathways
QuickGOQ8WXI2
Ontology : AmiGOcytoplasm  regulation of signal transduction  postsynaptic density  identical protein binding  neuron projection  neuronal cell body  postsynaptic membrane  extracellular exosome  
Ontology : EGO-EBIcytoplasm  regulation of signal transduction  postsynaptic density  identical protein binding  neuron projection  neuronal cell body  postsynaptic membrane  extracellular exosome  
NDEx NetworkCNKSR2
Atlas of Cancer Signalling NetworkCNKSR2
Wikipedia pathwaysCNKSR2
Orthology - Evolution
OrthoDB22866
GeneTree (enSembl)ENSG00000149970
Phylogenetic Trees/Animal Genes : TreeFamCNKSR2
HOVERGENQ8WXI2
HOGENOMQ8WXI2
Homologs : HomoloGeneCNKSR2
Homology/Alignments : Family Browser (UCSC)CNKSR2
Gene fusions - Rearrangements
Tumor Fusion PortalCNKSR2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCNKSR2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CNKSR2
dbVarCNKSR2
ClinVarCNKSR2
1000_GenomesCNKSR2 
Exome Variant ServerCNKSR2
ExAC (Exome Aggregation Consortium)ENSG00000149970
GNOMAD BrowserENSG00000149970
Genetic variants : HAPMAP22866
Genomic Variants (DGV)CNKSR2 [DGVbeta]
DECIPHERCNKSR2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCNKSR2 
Mutations
ICGC Data PortalCNKSR2 
TCGA Data PortalCNKSR2 
Broad Tumor PortalCNKSR2
OASIS PortalCNKSR2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCNKSR2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCNKSR2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch CNKSR2
DgiDB (Drug Gene Interaction Database)CNKSR2
DoCM (Curated mutations)CNKSR2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CNKSR2 (select a term)
intoGenCNKSR2
Cancer3DCNKSR2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300724   
Orphanet23427   
DisGeNETCNKSR2
MedgenCNKSR2
Genetic Testing Registry CNKSR2
NextProtQ8WXI2 [Medical]
TSGene22866
GENETestsCNKSR2
Target ValidationCNKSR2
Huge Navigator CNKSR2 [HugePedia]
snp3D : Map Gene to Disease22866
BioCentury BCIQCNKSR2
ClinGenCNKSR2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD22866
Chemical/Pharm GKB GenePA134867759
Clinical trialCNKSR2
Miscellaneous
canSAR (ICR)CNKSR2 (select the gene name)
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCNKSR2
EVEXCNKSR2
GoPubMedCNKSR2
iHOPCNKSR2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 13:59:20 CET 2017

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