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CNNM2 (cyclin and CBS domain divalent metal cation transport mediator 2)

Identity

Alias_namesACDP2
cyclin M2
Other aliasHOMG6
HOMGSMR
HGNC (Hugo) CNNM2
LocusID (NCBI) 54805
Atlas_Id 61943
Location 10q24.32  [Link to chromosome band 10q24]
Location_base_pair Starts at 102918318 and ends at 103078587 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BOLA2 (16p11.2) / CNNM2 (10q24.32)CNNM2 (10q24.32) / NOTCH4 (6p21.32)CNNM2 (10q24.32) / SUFU (10q24.32)
TPM4 (19p13.12) / CNNM2 (10q24.32)CNNM2 SUFUCNNM2 NOTCH4

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CNNM2   103
Cards
Entrez_Gene (NCBI)CNNM2  54805  cyclin and CBS domain divalent metal cation transport mediator 2
AliasesACDP2; HOMG6; HOMGSMR
GeneCards (Weizmann)CNNM2
Ensembl hg19 (Hinxton)ENSG00000148842 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000148842 [Gene_View]  chr10:102918318-103078587 [Contig_View]  CNNM2 [Vega]
ICGC DataPortalENSG00000148842
TCGA cBioPortalCNNM2
AceView (NCBI)CNNM2
Genatlas (Paris)CNNM2
WikiGenes54805
SOURCE (Princeton)CNNM2
Genetics Home Reference (NIH)CNNM2
Genomic and cartography
GoldenPath hg38 (UCSC)CNNM2  -     chr10:102918318-103078587 +  10q24.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CNNM2  -     10q24.32   [Description]    (hg19-Feb_2009)
EnsemblCNNM2 - 10q24.32 [CytoView hg19]  CNNM2 - 10q24.32 [CytoView hg38]
Mapping of homologs : NCBICNNM2 [Mapview hg19]  CNNM2 [Mapview hg38]
OMIM607803   613882   616418   
Gene and transcription
Genbank (Entrez)AF216962 AK000071 AK023066 AK023479 AK090785
RefSeq transcript (Entrez)NM_017649 NM_199076 NM_199077
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CNNM2
Cluster EST : UnigeneHs.643509 [ NCBI ]
CGAP (NCI)Hs.643509
Alternative Splicing GalleryENSG00000148842
Gene ExpressionCNNM2 [ NCBI-GEO ]   CNNM2 [ EBI - ARRAY_EXPRESS ]   CNNM2 [ SEEK ]   CNNM2 [ MEM ]
Gene Expression Viewer (FireBrowse)CNNM2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54805
GTEX Portal (Tissue expression)CNNM2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H8M5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H8M5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H8M5
Splice isoforms : SwissVarQ9H8M5
PhosPhoSitePlusQ9H8M5
Domaine pattern : Prosite (Expaxy)CBS (PS51371)   
Domains : Interpro (EBI)CBS_dom    DUF21    RmlC-like_jellyroll   
Domain families : Pfam (Sanger)CBS (PF00571)    DUF21 (PF01595)   
Domain families : Pfam (NCBI)pfam00571    pfam01595   
Conserved Domain (NCBI)CNNM2
DMDM Disease mutations54805
Blocks (Seattle)CNNM2
PDB (SRS)4IY0    4IY2    4IY4    4IYS   
PDB (PDBSum)4IY0    4IY2    4IY4    4IYS   
PDB (IMB)4IY0    4IY2    4IY4    4IYS   
PDB (RSDB)4IY0    4IY2    4IY4    4IYS   
Structural Biology KnowledgeBase4IY0    4IY2    4IY4    4IYS   
SCOP (Structural Classification of Proteins)4IY0    4IY2    4IY4    4IYS   
CATH (Classification of proteins structures)4IY0    4IY2    4IY4    4IYS   
SuperfamilyQ9H8M5
Human Protein AtlasENSG00000148842
Peptide AtlasQ9H8M5
HPRD07418
IPIIPI00401870   IPI01019112   IPI00006084   IPI00396142   
Protein Interaction databases
DIP (DOE-UCLA)Q9H8M5
IntAct (EBI)Q9H8M5
FunCoupENSG00000148842
BioGRIDCNNM2
STRING (EMBL)CNNM2
ZODIACCNNM2
Ontologies - Pathways
QuickGOQ9H8M5
Ontology : AmiGOATP binding  magnesium ion homeostasis  magnesium ion transmembrane transporter activity  integral component of membrane  basolateral plasma membrane  intracellular membrane-bounded organelle  magnesium ion transmembrane transport  
Ontology : EGO-EBIATP binding  magnesium ion homeostasis  magnesium ion transmembrane transporter activity  integral component of membrane  basolateral plasma membrane  intracellular membrane-bounded organelle  magnesium ion transmembrane transport  
NDEx NetworkCNNM2
Atlas of Cancer Signalling NetworkCNNM2
Wikipedia pathwaysCNNM2
Orthology - Evolution
OrthoDB54805
GeneTree (enSembl)ENSG00000148842
Phylogenetic Trees/Animal Genes : TreeFamCNNM2
HOVERGENQ9H8M5
HOGENOMQ9H8M5
Homologs : HomoloGeneCNNM2
Homology/Alignments : Family Browser (UCSC)CNNM2
Gene fusions - Rearrangements
Fusion: TCGACNNM2 SUFU
Fusion: TCGACNNM2 NOTCH4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCNNM2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CNNM2
dbVarCNNM2
ClinVarCNNM2
1000_GenomesCNNM2 
Exome Variant ServerCNNM2
ExAC (Exome Aggregation Consortium)CNNM2 (select the gene name)
Genetic variants : HAPMAP54805
Genomic Variants (DGV)CNNM2 [DGVbeta]
DECIPHERCNNM2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCNNM2 
Mutations
ICGC Data PortalCNNM2 
TCGA Data PortalCNNM2 
Broad Tumor PortalCNNM2
OASIS PortalCNNM2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCNNM2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCNNM2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CNNM2
DgiDB (Drug Gene Interaction Database)CNNM2
DoCM (Curated mutations)CNNM2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CNNM2 (select a term)
intoGenCNNM2
Cancer3DCNNM2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607803    613882    616418   
Orphanet10345   
MedgenCNNM2
Genetic Testing Registry CNNM2
NextProtQ9H8M5 [Medical]
TSGene54805
GENETestsCNNM2
Target ValidationCNNM2
Huge Navigator CNNM2 [HugePedia]
snp3D : Map Gene to Disease54805
BioCentury BCIQCNNM2
ClinGenCNNM2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54805
Chemical/Pharm GKB GenePA26669
Clinical trialCNNM2
Miscellaneous
canSAR (ICR)CNNM2 (select the gene name)
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCNNM2
EVEXCNNM2
GoPubMedCNNM2
iHOPCNNM2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 15:44:03 CEST 2017

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