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CNOT1 (CCR4-NOT transcription complex subunit 1)

Identity

Alias_namesNOT1
CCR4-NOT transcription complex
Alias_symbol (synonym)CDC39
NOT1H
KIAA1007
AD-005
Other alias
HGNC (Hugo) CNOT1
LocusID (NCBI) 23019
Atlas_Id 55343
Location 16q21  [Link to chromosome band 16q21]
Location_base_pair Starts at 58519946 and ends at 58629886 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
C16orf87 (16q11.2) / CNOT1 (16q21)CNOT1 (16q21) / CETP (16q13)CNOT1 (16q21) / CNOT1 (16q21)
CNOT1 (16q21) / ELF3 (1q32.1)CNOT1 (16q21) / ENTPD4 (8p21.3)CNOT1 (16q21) / RASSF8 (12p12.1)
CNOT1 (16q21) / RNU5E-1 (5q14.1)CNOT1 (16q21) / SMARCAD1 (4q22.3)REST (4q12) / CNOT1 (16q21)
C16orf87 16q11.2 / CNOT1 16q21CNOT1 16q21 / CETP 16q13CNOT1 16q21 / RASSF8 12p12.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CNOT1   7877
Cards
Entrez_Gene (NCBI)CNOT1  23019  CCR4-NOT transcription complex subunit 1
AliasesAD-005; CDC39; NOT1; NOT1H
GeneCards (Weizmann)CNOT1
Ensembl hg19 (Hinxton)ENSG00000125107 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125107 [Gene_View]  chr16:58519946-58629886 [Contig_View]  CNOT1 [Vega]
ICGC DataPortalENSG00000125107
TCGA cBioPortalCNOT1
AceView (NCBI)CNOT1
Genatlas (Paris)CNOT1
WikiGenes23019
SOURCE (Princeton)CNOT1
Genetics Home Reference (NIH)CNOT1
Genomic and cartography
GoldenPath hg38 (UCSC)CNOT1  -     chr16:58519946-58629886 -  16q21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CNOT1  -     16q21   [Description]    (hg19-Feb_2009)
EnsemblCNOT1 - 16q21 [CytoView hg19]  CNOT1 - 16q21 [CytoView hg38]
Mapping of homologs : NCBICNOT1 [Mapview hg19]  CNOT1 [Mapview hg38]
OMIM604917   
Gene and transcription
Genbank (Entrez)AB023224 AF110778 AJ346264 AK056927 AK075125
RefSeq transcript (Entrez)NM_001265612 NM_016284 NM_206999
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CNOT1
Cluster EST : UnigeneHs.731691 [ NCBI ]
CGAP (NCI)Hs.731691
Alternative Splicing GalleryENSG00000125107
Gene ExpressionCNOT1 [ NCBI-GEO ]   CNOT1 [ EBI - ARRAY_EXPRESS ]   CNOT1 [ SEEK ]   CNOT1 [ MEM ]
Gene Expression Viewer (FireBrowse)CNOT1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23019
GTEX Portal (Tissue expression)CNOT1
Protein : pattern, domain, 3D structure
UniProt/SwissProtA5YKK6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtA5YKK6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProA5YKK6
Splice isoforms : SwissVarA5YKK6
PhosPhoSitePlusA5YKK6
Domains : Interpro (EBI)CCR4-Not_Not1_C    CCR4-Not_Not1su_DUF3819    CNOT1_CAF1_bind    CNOT1_HEAT    CNOT1_TTP_bind   
Domain families : Pfam (Sanger)CNOT1_CAF1_bind (PF16415)    CNOT1_HEAT (PF16418)    CNOT1_TTP_bind (PF16417)    DUF3819 (PF12842)    Not1 (PF04054)   
Domain families : Pfam (NCBI)pfam16415    pfam16418    pfam16417    pfam12842    pfam04054   
Conserved Domain (NCBI)CNOT1
DMDM Disease mutations23019
Blocks (Seattle)CNOT1
PDB (SRS)4C0D    4CQO    4CRU    4CRV    4CRW    4CT4    4CT6    4CT7    4GMJ    4GML    4J8S    5ANR    5FU6    5FU7   
PDB (PDBSum)4C0D    4CQO    4CRU    4CRV    4CRW    4CT4    4CT6    4CT7    4GMJ    4GML    4J8S    5ANR    5FU6    5FU7   
PDB (IMB)4C0D    4CQO    4CRU    4CRV    4CRW    4CT4    4CT6    4CT7    4GMJ    4GML    4J8S    5ANR    5FU6    5FU7   
PDB (RSDB)4C0D    4CQO    4CRU    4CRV    4CRW    4CT4    4CT6    4CT7    4GMJ    4GML    4J8S    5ANR    5FU6    5FU7   
Structural Biology KnowledgeBase4C0D    4CQO    4CRU    4CRV    4CRW    4CT4    4CT6    4CT7    4GMJ    4GML    4J8S    5ANR    5FU6    5FU7   
SCOP (Structural Classification of Proteins)4C0D    4CQO    4CRU    4CRV    4CRW    4CT4    4CT6    4CT7    4GMJ    4GML    4J8S    5ANR    5FU6    5FU7   
CATH (Classification of proteins structures)4C0D    4CQO    4CRU    4CRV    4CRW    4CT4    4CT6    4CT7    4GMJ    4GML    4J8S    5ANR    5FU6    5FU7   
SuperfamilyA5YKK6
Human Protein AtlasENSG00000125107
Peptide AtlasA5YKK6
HPRD11999
IPIIPI00166010   IPI00880052   IPI00642900   IPI00410157   IPI01015931   IPI00032299   IPI01018639   IPI01024738   
Protein Interaction databases
DIP (DOE-UCLA)A5YKK6
IntAct (EBI)A5YKK6
FunCoupENSG00000125107
BioGRIDCNOT1
STRING (EMBL)CNOT1
ZODIACCNOT1
Ontologies - Pathways
QuickGOA5YKK6
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  nuclear-transcribed mRNA poly(A) tail shortening  P-body  P-body  RNA binding  poly(A)-specific ribonuclease activity  protein binding  extracellular space  nucleus  cytosol  cytosol  transcription, DNA-templated  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  multicellular organism development  positive regulation of cytoplasmic mRNA processing body assembly  membrane  negative regulation of translation  protein domain specific binding  CCR4-NOT complex  CCR4-NOT core complex  estrogen receptor binding  protein complex scaffold  negative regulation of intracellular estrogen receptor signaling pathway  gene silencing by miRNA  retinoic acid receptor binding  negative regulation of retinoic acid receptor signaling pathway  positive regulation of nuclear-transcribed mRNA poly(A) tail shortening  positive regulation of nuclear-transcribed mRNA poly(A) tail shortening  positive regulation of mRNA catabolic process  armadillo repeat domain binding  RNA phosphodiester bond hydrolysis, exonucleolytic  positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  regulation of stem cell population maintenance  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  nuclear-transcribed mRNA poly(A) tail shortening  P-body  P-body  RNA binding  poly(A)-specific ribonuclease activity  protein binding  extracellular space  nucleus  cytosol  cytosol  transcription, DNA-templated  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  multicellular organism development  positive regulation of cytoplasmic mRNA processing body assembly  membrane  negative regulation of translation  protein domain specific binding  CCR4-NOT complex  CCR4-NOT core complex  estrogen receptor binding  protein complex scaffold  negative regulation of intracellular estrogen receptor signaling pathway  gene silencing by miRNA  retinoic acid receptor binding  negative regulation of retinoic acid receptor signaling pathway  positive regulation of nuclear-transcribed mRNA poly(A) tail shortening  positive regulation of nuclear-transcribed mRNA poly(A) tail shortening  positive regulation of mRNA catabolic process  armadillo repeat domain binding  RNA phosphodiester bond hydrolysis, exonucleolytic  positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  regulation of stem cell population maintenance  
Pathways : KEGGRNA degradation   
NDEx NetworkCNOT1
Atlas of Cancer Signalling NetworkCNOT1
Wikipedia pathwaysCNOT1
Orthology - Evolution
OrthoDB23019
GeneTree (enSembl)ENSG00000125107
Phylogenetic Trees/Animal Genes : TreeFamCNOT1
HOVERGENA5YKK6
HOGENOMA5YKK6
Homologs : HomoloGeneCNOT1
Homology/Alignments : Family Browser (UCSC)CNOT1
Gene fusions - Rearrangements
Fusion : MitelmanC16orf87/CNOT1 [16q11.2/16q21]  [t(16;16)(q11;q21)]  
Fusion : MitelmanCNOT1/RASSF8 [16q21/12p12.1]  [t(12;16)(p12;q21)]  
Fusion: TCGAC16orf87 16q11.2 CNOT1 16q21 KIRC
Fusion: TCGACNOT1 16q21 CETP 16q13 OV
Fusion: TCGACNOT1 16q21 RASSF8 12p12.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCNOT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CNOT1
dbVarCNOT1
ClinVarCNOT1
1000_GenomesCNOT1 
Exome Variant ServerCNOT1
ExAC (Exome Aggregation Consortium)CNOT1 (select the gene name)
Genetic variants : HAPMAP23019
Genomic Variants (DGV)CNOT1 [DGVbeta]
DECIPHERCNOT1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCNOT1 
Mutations
ICGC Data PortalCNOT1 
TCGA Data PortalCNOT1 
Broad Tumor PortalCNOT1
OASIS PortalCNOT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCNOT1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCNOT1
intOGen PortalCNOT1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CNOT1
DgiDB (Drug Gene Interaction Database)CNOT1
DoCM (Curated mutations)CNOT1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CNOT1 (select a term)
intoGenCNOT1
Cancer3DCNOT1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604917   
Orphanet
MedgenCNOT1
Genetic Testing Registry CNOT1
NextProtA5YKK6 [Medical]
TSGene23019
GENETestsCNOT1
Target ValidationCNOT1
Huge Navigator CNOT1 [HugePedia]
snp3D : Map Gene to Disease23019
BioCentury BCIQCNOT1
ClinGenCNOT1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23019
Chemical/Pharm GKB GenePA26672
Clinical trialCNOT1
Miscellaneous
canSAR (ICR)CNOT1 (select the gene name)
Probes
Litterature
PubMed74 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCNOT1
EVEXCNOT1
GoPubMedCNOT1
iHOPCNOT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:03:03 CEST 2017

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