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CNOT2 (CCR4-NOT transcription complex subunit 2)

Identity

Alias (NCBI)CDC36
HSPC131
IDNADFS
NOT2
NOT2H
HGNC (Hugo) CNOT2
HGNC Alias symbCDC36
NOT2H
HGNC Previous nameNOT2
HGNC Previous nameCCR4-NOT transcription complex, subunit 2
LocusID (NCBI) 4848
Atlas_Id 40114
Location 12q15  [Link to chromosome band 12q15]
Location_base_pair Starts at 70243433 and ends at 70355257 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CNOT2 (12q15) / AHSG (3q27.3)CNOT2 (12q15) / ASTN2 (9q33.1)CNOT2 (12q15) / NUP107 (12q15)
CNOT2 (12q15) / PDE3A (12p12.2)CNOT2 (12q15) / PTMA (2q37.1)CNOT2 (12q15) / PTPRR (12q15)
CNOT2 (12q15) / RAB3IP (12q15)CNOT2 (12q15) / SLC45A4 (8q24.3)FAU (11q13.1) / CNOT2 (12q15)
PCDH9 (13q21.32) / CNOT2 (12q15)CNOT2 12q15 / NUP107 12q15CNOT2 12q15 / PDE3A 12p12.2
CNOT2 12q15 / RAB3IP 12q15CNOT2 12q15 / SLC45A4 8q24.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(9;17)(p13;p12) PAX5/NCOR1


External links

 

Nomenclature
HGNC (Hugo)CNOT2   7878
Cards
Entrez_Gene (NCBI)CNOT2    CCR4-NOT transcription complex subunit 2
AliasesCDC36; HSPC131; IDNADFS; NOT2; 
NOT2H
GeneCards (Weizmann)CNOT2
Ensembl hg19 (Hinxton)ENSG00000111596 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000111596 [Gene_View]  ENSG00000111596 [Sequence]  chr12:70243433-70355257 [Contig_View]  CNOT2 [Vega]
ICGC DataPortalENSG00000111596
TCGA cBioPortalCNOT2
AceView (NCBI)CNOT2
Genatlas (Paris)CNOT2
SOURCE (Princeton)CNOT2
Genetics Home Reference (NIH)CNOT2
Genomic and cartography
GoldenPath hg38 (UCSC)CNOT2  -     chr12:70243433-70355257 +  12q15   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CNOT2  -     12q15   [Description]    (hg19-Feb_2009)
GoldenPathCNOT2 - 12q15 [CytoView hg19]  CNOT2 - 12q15 [CytoView hg38]
ImmunoBaseENSG00000111596
Genome Data Viewer NCBICNOT2 [Mapview hg19]  
OMIM604909   618608   
Gene and transcription
Genbank (Entrez)AA234384 AF044215 AF113226 AF161480 AF180473
RefSeq transcript (Entrez)NM_001199302 NM_001199303 NM_014515
Consensus coding sequences : CCDS (NCBI)CNOT2
Gene ExpressionCNOT2 [ NCBI-GEO ]   CNOT2 [ EBI - ARRAY_EXPRESS ]   CNOT2 [ SEEK ]   CNOT2 [ MEM ]
Gene Expression Viewer (FireBrowse)CNOT2 [ Firebrowse - Broad ]
GenevisibleExpression of CNOT2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4848
GTEX Portal (Tissue expression)CNOT2
Human Protein AtlasENSG00000111596-CNOT2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NZN8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NZN8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NZN8
PhosPhoSitePlusQ9NZN8
Domains : Interpro (EBI)CCR4-NOT_su2/3/5_N_sf    Not2/3/5    NOT2/3/5_C   
Domain families : Pfam (Sanger)NOT2_3_5 (PF04153)   
Domain families : Pfam (NCBI)pfam04153   
Conserved Domain (NCBI)CNOT2
PDB (RSDB)4C0D    4C0F    5FU6    5FU7   
PDB Europe4C0D    4C0F    5FU6    5FU7   
PDB (PDBSum)4C0D    4C0F    5FU6    5FU7   
PDB (IMB)4C0D    4C0F    5FU6    5FU7   
Structural Biology KnowledgeBase4C0D    4C0F    5FU6    5FU7   
SCOP (Structural Classification of Proteins)4C0D    4C0F    5FU6    5FU7   
CATH (Classification of proteins structures)4C0D    4C0F    5FU6    5FU7   
SuperfamilyQ9NZN8
AlphaFold pdb e-kbQ9NZN8   
Human Protein Atlas [tissue]ENSG00000111596-CNOT2 [tissue]
HPRD05367
Protein Interaction databases
DIP (DOE-UCLA)Q9NZN8
IntAct (EBI)Q9NZN8
BioGRIDCNOT2
STRING (EMBL)CNOT2
ZODIACCNOT2
Ontologies - Pathways
QuickGOQ9NZN8
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  nuclear-transcribed mRNA poly(A) tail shortening  nuclear-transcribed mRNA poly(A) tail shortening  P-body  transcription corepressor binding  trophectodermal cell differentiation  transcription coregulator activity  poly(A)-specific ribonuclease activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  cytosol  plasma membrane  regulation of transcription by RNA polymerase II  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  positive regulation of cytoplasmic mRNA processing body assembly  membrane  CCR4-NOT complex  CCR4-NOT core complex  gene silencing by RNA  negative regulation of intracellular estrogen receptor signaling pathway  RNA phosphodiester bond hydrolysis, exonucleolytic  regulation of stem cell population maintenance  regulation of stem cell population maintenance  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  nuclear-transcribed mRNA poly(A) tail shortening  nuclear-transcribed mRNA poly(A) tail shortening  P-body  transcription corepressor binding  trophectodermal cell differentiation  transcription coregulator activity  poly(A)-specific ribonuclease activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  cytosol  plasma membrane  regulation of transcription by RNA polymerase II  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  positive regulation of cytoplasmic mRNA processing body assembly  membrane  CCR4-NOT complex  CCR4-NOT core complex  gene silencing by RNA  negative regulation of intracellular estrogen receptor signaling pathway  RNA phosphodiester bond hydrolysis, exonucleolytic  regulation of stem cell population maintenance  regulation of stem cell population maintenance  
Pathways : KEGGRNA degradation   
NDEx NetworkCNOT2
Atlas of Cancer Signalling NetworkCNOT2
Wikipedia pathwaysCNOT2
Orthology - Evolution
OrthoDB4848
GeneTree (enSembl)ENSG00000111596
Phylogenetic Trees/Animal Genes : TreeFamCNOT2
Homologs : HomoloGeneCNOT2
Homology/Alignments : Family Browser (UCSC)CNOT2
Gene fusions - Rearrangements
Fusion : MitelmanCNOT2/ASTN2 [12q15/9q33.1]  
Fusion : MitelmanCNOT2/PDE3A [12q15/12p12.2]  
Fusion : MitelmanCNOT2/SLC45A4 [12q15/8q24.3]  
Fusion : QuiverCNOT2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCNOT2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CNOT2
dbVarCNOT2
ClinVarCNOT2
MonarchCNOT2
1000_GenomesCNOT2 
Exome Variant ServerCNOT2
GNOMAD BrowserENSG00000111596
Varsome BrowserCNOT2
ACMGCNOT2 variants
VarityQ9NZN8
Genomic Variants (DGV)CNOT2 [DGVbeta]
DECIPHERCNOT2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCNOT2 
Mutations
ICGC Data PortalCNOT2 
TCGA Data PortalCNOT2 
Broad Tumor PortalCNOT2
OASIS PortalCNOT2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCNOT2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCNOT2
Mutations and Diseases : HGMDCNOT2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCNOT2
DgiDB (Drug Gene Interaction Database)CNOT2
DoCM (Curated mutations)CNOT2
CIViC (Clinical Interpretations of Variants in Cancer)CNOT2
Cancer3DCNOT2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604909    618608   
Orphanet
DisGeNETCNOT2
MedgenCNOT2
Genetic Testing Registry CNOT2
NextProtQ9NZN8 [Medical]
GENETestsCNOT2
Target ValidationCNOT2
Huge Navigator CNOT2 [HugePedia]
ClinGenCNOT2
Clinical trials, drugs, therapy
MyCancerGenomeCNOT2
Protein Interactions : CTDCNOT2
Pharm GKB GenePA26673
PharosQ9NZN8
Clinical trialCNOT2
Miscellaneous
canSAR (ICR)CNOT2
HarmonizomeCNOT2
DataMed IndexCNOT2
Probes
Litterature
PubMed58 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCNOT2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:04:34 CEST 2021

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