Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CNOT3 (CCR4-NOT transcription complex subunit 3)

Identity

Alias_namesyeast) homolog
NOT3
Alias_symbol (synonym)NOT3H
KIAA0691
LENG2
Other alias
HGNC (Hugo) CNOT3
LocusID (NCBI) 4849
Atlas_Id 53235
Location 19q13.42  [Link to chromosome band 19q13]
Location_base_pair Starts at 54137720 and ends at 54155708 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CNOT3   7879
Cards
Entrez_Gene (NCBI)CNOT3  4849  CCR4-NOT transcription complex subunit 3
AliasesLENG2; NOT3; NOT3H
GeneCards (Weizmann)CNOT3
Ensembl hg19 (Hinxton)ENSG00000088038 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000088038 [Gene_View]  chr19:54137720-54155708 [Contig_View]  CNOT3 [Vega]
ICGC DataPortalENSG00000088038
TCGA cBioPortalCNOT3
AceView (NCBI)CNOT3
Genatlas (Paris)CNOT3
WikiGenes4849
SOURCE (Princeton)CNOT3
Genetics Home Reference (NIH)CNOT3
Genomic and cartography
GoldenPath hg38 (UCSC)CNOT3  -     chr19:54137720-54155708 +  19q13.42   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CNOT3  -     19q13.42   [Description]    (hg19-Feb_2009)
EnsemblCNOT3 - 19q13.42 [CytoView hg19]  CNOT3 - 19q13.42 [CytoView hg38]
Mapping of homologs : NCBICNOT3 [Mapview hg19]  CNOT3 [Mapview hg38]
OMIM604910   
Gene and transcription
Genbank (Entrez)AB014591 AF180474 AF211967 AI660119 AK160386
RefSeq transcript (Entrez)NM_014516
RefSeq genomic (Entrez)NC_000019 NC_018930 NT_187693 NW_003571054 NW_003571055 NW_003571056 NW_003571057 NW_003571058 NW_003571059 NW_003571060 NW_003571061
Consensus coding sequences : CCDS (NCBI)CNOT3
Cluster EST : UnigeneHs.343571 [ NCBI ]
CGAP (NCI)Hs.343571
Alternative Splicing GalleryENSG00000088038
Gene ExpressionCNOT3 [ NCBI-GEO ]   CNOT3 [ EBI - ARRAY_EXPRESS ]   CNOT3 [ SEEK ]   CNOT3 [ MEM ]
Gene Expression Viewer (FireBrowse)CNOT3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4849
GTEX Portal (Tissue expression)CNOT3
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75175   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75175  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75175
Splice isoforms : SwissVarO75175
PhosPhoSitePlusO75175
Domains : Interpro (EBI)CCR4-NOT_su3/5    NOT    Not_N   
Domain families : Pfam (Sanger)NOT2_3_5 (PF04153)    Not3 (PF04065)   
Domain families : Pfam (NCBI)pfam04153    pfam04065   
Conserved Domain (NCBI)CNOT3
DMDM Disease mutations4849
Blocks (Seattle)CNOT3
PDB (SRS)4C0D    4C0G    5FU6    5FU7   
PDB (PDBSum)4C0D    4C0G    5FU6    5FU7   
PDB (IMB)4C0D    4C0G    5FU6    5FU7   
PDB (RSDB)4C0D    4C0G    5FU6    5FU7   
Structural Biology KnowledgeBase4C0D    4C0G    5FU6    5FU7   
SCOP (Structural Classification of Proteins)4C0D    4C0G    5FU6    5FU7   
CATH (Classification of proteins structures)4C0D    4C0G    5FU6    5FU7   
SuperfamilyO75175
Human Protein AtlasENSG00000088038
Peptide AtlasO75175
HPRD05368
IPIIPI00005015   IPI00186188   IPI00478453   IPI00892660   IPI00892783   IPI01012769   IPI00877616   IPI00945946   
Protein Interaction databases
DIP (DOE-UCLA)O75175
IntAct (EBI)O75175
FunCoupENSG00000088038
BioGRIDCNOT3
STRING (EMBL)CNOT3
ZODIACCNOT3
Ontologies - Pathways
QuickGOO75175
Ontology : AmiGOnuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  nuclear-transcribed mRNA poly(A) tail shortening  P-body  P-body  trophectodermal cell differentiation  protein binding  nucleus  cytosol  transcription, DNA-templated  regulation of transcription, DNA-templated  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  negative regulation of translation  CCR4-NOT complex  CCR4-NOT core complex  gene silencing by RNA  regulation of stem cell population maintenance  
Ontology : EGO-EBInuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  nuclear-transcribed mRNA poly(A) tail shortening  P-body  P-body  trophectodermal cell differentiation  protein binding  nucleus  cytosol  transcription, DNA-templated  regulation of transcription, DNA-templated  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  negative regulation of translation  CCR4-NOT complex  CCR4-NOT core complex  gene silencing by RNA  regulation of stem cell population maintenance  
Pathways : KEGGRNA degradation   
NDEx NetworkCNOT3
Atlas of Cancer Signalling NetworkCNOT3
Wikipedia pathwaysCNOT3
Orthology - Evolution
OrthoDB4849
GeneTree (enSembl)ENSG00000088038
Phylogenetic Trees/Animal Genes : TreeFamCNOT3
HOVERGENO75175
HOGENOMO75175
Homologs : HomoloGeneCNOT3
Homology/Alignments : Family Browser (UCSC)CNOT3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCNOT3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CNOT3
dbVarCNOT3
ClinVarCNOT3
1000_GenomesCNOT3 
Exome Variant ServerCNOT3
ExAC (Exome Aggregation Consortium)CNOT3 (select the gene name)
Genetic variants : HAPMAP4849
Genomic Variants (DGV)CNOT3 [DGVbeta]
DECIPHERCNOT3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCNOT3 
Mutations
ICGC Data PortalCNOT3 
TCGA Data PortalCNOT3 
Broad Tumor PortalCNOT3
OASIS PortalCNOT3 [ Somatic mutations - Copy number]
Cancer Gene: CensusCNOT3 
Somatic Mutations in Cancer : COSMICCNOT3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCNOT3
intOGen PortalCNOT3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CNOT3
DgiDB (Drug Gene Interaction Database)CNOT3
DoCM (Curated mutations)CNOT3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CNOT3 (select a term)
intoGenCNOT3
Cancer3DCNOT3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604910   
Orphanet14434   
MedgenCNOT3
Genetic Testing Registry CNOT3
NextProtO75175 [Medical]
TSGene4849
GENETestsCNOT3
Target ValidationCNOT3
Huge Navigator CNOT3 [HugePedia]
snp3D : Map Gene to Disease4849
BioCentury BCIQCNOT3
ClinGenCNOT3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4849
Chemical/Pharm GKB GenePA26674
Clinical trialCNOT3
Miscellaneous
canSAR (ICR)CNOT3 (select the gene name)
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCNOT3
EVEXCNOT3
GoPubMedCNOT3
iHOPCNOT3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Sep 18 13:50:15 CEST 2017

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