CNOT4 (CCR4-NOT transcription complex subunit 4)

2015-08-01  

Identity

HGNC
LOCATION
7q33
LOCUSID
ALIAS
CLONE243,NOT4,NOT4H
FUSION GENES

Other Information

Locus ID:

NCBI: 4850
MIM: 604911
HGNC: 7880
Ensembl: ENSG00000080802

Variants:

dbSNP: 4850
ClinVar: 4850
TCGA: ENSG00000080802
COSMIC: CNOT4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000080802ENST00000315544O95628
ENSG00000080802ENST00000315544A0A024R785
ENSG00000080802ENST00000356162A0A0A0MRD2
ENSG00000080802ENST00000361528O95628
ENSG00000080802ENST00000414802O95628
ENSG00000080802ENST00000423368O95628
ENSG00000080802ENST00000423368A0A024R781
ENSG00000080802ENST00000428680O95628
ENSG00000080802ENST00000428680A0A024R776
ENSG00000080802ENST00000451834O95628
ENSG00000080802ENST00000541284O95628

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
Deadenylation of mRNAREACTOMER-HSA-429947
TP53 Regulates Transcription of Cell Cycle GenesREACTOMER-HSA-6791312
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertainREACTOMER-HSA-6804115

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
195583672009Human Ccr4-Not complexes contain variable deadenylase subunits.73
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
150013592004An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair.20
285362882017CNOT4-Mediated Ubiquitination of Influenza A Virus Nucleoprotein Promotes Viral RNA Replication.14
221590382012Not4 enhances JAK/STAT pathway-dependent gene expression in Drosophila and in human cells.9
298613912018Ubiquitination of ABCE1 by NOT4 in Response to Mitochondrial Damage Links Co-translational Quality Control to PINK1-Directed Mitophagy.7
256634492015Polymorphisms in miRNA processing genes and their role in osteosarcoma risk.4
259334332015Protein Degradation of RNA Polymerase II-Association Factor 1(PAF1) Is Controlled by CNOT4 and 26S Proteasome.3
306922042019A conserved CAF40-binding motif in metazoan NOT4 mediates association with the CCR4-NOT complex.2
298023282018The conserved RNA recognition motif and C3H1 domain of the Not4 ubiquitin ligase regulate in vivo ligase function.1

Citation

Dessen P

CNOT4 (CCR4-NOT transcription complex subunit 4)

Atlas Genet Cytogenet Oncol Haematol. 2015-08-01

Online version: http://atlasgeneticsoncology.org/gene/55380/cnot4