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CNOT6 (CCR4-NOT transcription complex subunit 6)

Identity

Alias_namesCCR4-NOT transcription complex
Alias_symbol (synonym)CCR4
KIAA1194
Ccr4a
Other alias
HGNC (Hugo) CNOT6
LocusID (NCBI) 57472
Atlas_Id 56453
Location 5q35.3  [Link to chromosome band 5q35]
Location_base_pair Starts at 180494399 and ends at 180578405 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
H2AFY (5q31.1) / CNOT6 (5q35.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CNOT6   14099
Cards
Entrez_Gene (NCBI)CNOT6  57472  CCR4-NOT transcription complex subunit 6
AliasesCCR4; Ccr4a
GeneCards (Weizmann)CNOT6
Ensembl hg19 (Hinxton)ENSG00000113300 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000113300 [Gene_View]  chr5:180494399-180578405 [Contig_View]  CNOT6 [Vega]
ICGC DataPortalENSG00000113300
TCGA cBioPortalCNOT6
AceView (NCBI)CNOT6
Genatlas (Paris)CNOT6
WikiGenes57472
SOURCE (Princeton)CNOT6
Genetics Home Reference (NIH)CNOT6
Genomic and cartography
GoldenPath hg38 (UCSC)CNOT6  -     chr5:180494399-180578405 +  5q35.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CNOT6  -     5q35.3   [Description]    (hg19-Feb_2009)
EnsemblCNOT6 - 5q35.3 [CytoView hg19]  CNOT6 - 5q35.3 [CytoView hg38]
Mapping of homologs : NCBICNOT6 [Mapview hg19]  CNOT6 [Mapview hg38]
OMIM608951   
Gene and transcription
Genbank (Entrez)AB033020 AI025725 AK023599 AK314752 AL110144
RefSeq transcript (Entrez)NM_001303241 NM_015455
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CNOT6
Cluster EST : UnigeneHs.608380 [ NCBI ]
CGAP (NCI)Hs.608380
Alternative Splicing GalleryENSG00000113300
Gene ExpressionCNOT6 [ NCBI-GEO ]   CNOT6 [ EBI - ARRAY_EXPRESS ]   CNOT6 [ SEEK ]   CNOT6 [ MEM ]
Gene Expression Viewer (FireBrowse)CNOT6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57472
GTEX Portal (Tissue expression)CNOT6
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9ULM6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9ULM6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9ULM6
Splice isoforms : SwissVarQ9ULM6
Catalytic activity : Enzyme3.1.13.4 [ Enzyme-Expasy ]   3.1.13.43.1.13.4 [ IntEnz-EBI ]   3.1.13.4 [ BRENDA ]   3.1.13.4 [ KEGG ]   
PhosPhoSitePlusQ9ULM6
Domaine pattern : Prosite (Expaxy)LRR (PS51450)   
Domains : Interpro (EBI)Endo/exonuclease/phosphatase    L_dom-like    Leu-rich_rpt    Leu-rich_rpt_typical-subtyp   
Domain families : Pfam (Sanger)Exo_endo_phos (PF03372)    LRR_8 (PF13855)   
Domain families : Pfam (NCBI)pfam03372    pfam13855   
Domain families : Smart (EMBL)LRR_TYP (SM00369)  
Conserved Domain (NCBI)CNOT6
DMDM Disease mutations57472
Blocks (Seattle)CNOT6
SuperfamilyQ9ULM6
Human Protein AtlasENSG00000113300
Peptide AtlasQ9ULM6
HPRD12341
IPIIPI00008205   IPI00152061   IPI00967167   
Protein Interaction databases
DIP (DOE-UCLA)Q9ULM6
IntAct (EBI)Q9ULM6
FunCoupENSG00000113300
BioGRIDCNOT6
STRING (EMBL)CNOT6
ZODIACCNOT6
Ontologies - Pathways
QuickGOQ9ULM6
Ontology : AmiGOnuclear-transcribed mRNA poly(A) tail shortening  nuclear-transcribed mRNA poly(A) tail shortening  RNA binding  exoribonuclease activity  poly(A)-specific ribonuclease activity  poly(A)-specific ribonuclease activity  protein binding  nucleus  cytosol  transcription, DNA-templated  regulation of transcription, DNA-templated  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  positive regulation of cell proliferation  positive regulation of cytoplasmic mRNA processing body assembly  membrane  CCR4-NOT complex  gene silencing by miRNA  exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay  metal ion binding  nuclear-transcribed mRNA catabolic process, no-go decay  RNA phosphodiester bond hydrolysis, exonucleolytic  positive regulation of ligand-dependent nuclear receptor transcription coactivator activity  
Ontology : EGO-EBInuclear-transcribed mRNA poly(A) tail shortening  nuclear-transcribed mRNA poly(A) tail shortening  RNA binding  exoribonuclease activity  poly(A)-specific ribonuclease activity  poly(A)-specific ribonuclease activity  protein binding  nucleus  cytosol  transcription, DNA-templated  regulation of transcription, DNA-templated  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  positive regulation of cell proliferation  positive regulation of cytoplasmic mRNA processing body assembly  membrane  CCR4-NOT complex  gene silencing by miRNA  exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay  metal ion binding  nuclear-transcribed mRNA catabolic process, no-go decay  RNA phosphodiester bond hydrolysis, exonucleolytic  positive regulation of ligand-dependent nuclear receptor transcription coactivator activity  
Pathways : KEGGRNA degradation   
NDEx NetworkCNOT6
Atlas of Cancer Signalling NetworkCNOT6
Wikipedia pathwaysCNOT6
Orthology - Evolution
OrthoDB57472
GeneTree (enSembl)ENSG00000113300
Phylogenetic Trees/Animal Genes : TreeFamCNOT6
HOVERGENQ9ULM6
HOGENOMQ9ULM6
Homologs : HomoloGeneCNOT6
Homology/Alignments : Family Browser (UCSC)CNOT6
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCNOT6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CNOT6
dbVarCNOT6
ClinVarCNOT6
1000_GenomesCNOT6 
Exome Variant ServerCNOT6
ExAC (Exome Aggregation Consortium)CNOT6 (select the gene name)
Genetic variants : HAPMAP57472
Genomic Variants (DGV)CNOT6 [DGVbeta]
DECIPHERCNOT6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCNOT6 
Mutations
ICGC Data PortalCNOT6 
TCGA Data PortalCNOT6 
Broad Tumor PortalCNOT6
OASIS PortalCNOT6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCNOT6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCNOT6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CNOT6
DgiDB (Drug Gene Interaction Database)CNOT6
DoCM (Curated mutations)CNOT6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CNOT6 (select a term)
intoGenCNOT6
Cancer3DCNOT6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608951   
Orphanet
MedgenCNOT6
Genetic Testing Registry CNOT6
NextProtQ9ULM6 [Medical]
TSGene57472
GENETestsCNOT6
Huge Navigator CNOT6 [HugePedia]
snp3D : Map Gene to Disease57472
BioCentury BCIQCNOT6
ClinGenCNOT6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57472
Chemical/Pharm GKB GenePA26677
Clinical trialCNOT6
Miscellaneous
canSAR (ICR)CNOT6 (select the gene name)
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCNOT6
EVEXCNOT6
GoPubMedCNOT6
iHOPCNOT6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:11:10 CEST 2017

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