Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CNOT6 (CCR4-NOT transcription complex subunit 6)

Identity

Alias (NCBI)CCR4
Ccr4a
HGNC (Hugo) CNOT6
HGNC Alias symbCCR4
KIAA1194
Ccr4a
HGNC Previous nameCCR4-NOT transcription complex, subunit 6
LocusID (NCBI) 57472
Atlas_Id 56453
Location 5q35.3  [Link to chromosome band 5q35]
Location_base_pair Starts at 180541654 and ends at 180578357 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
H2AFY (5q31.1) / CNOT6 (5q35.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  del(5q) in acute lymphoblastic leukemia (ALL)


External links

Nomenclature
HGNC (Hugo)CNOT6   14099
Cards
Entrez_Gene (NCBI)CNOT6    CCR4-NOT transcription complex subunit 6
AliasesCCR4; Ccr4a
GeneCards (Weizmann)CNOT6
Ensembl hg19 (Hinxton)ENSG00000113300 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000113300 [Gene_View]  ENSG00000113300 [Sequence]  chr5:180541654-180578357 [Contig_View]  CNOT6 [Vega]
ICGC DataPortalENSG00000113300
TCGA cBioPortalCNOT6
AceView (NCBI)CNOT6
Genatlas (Paris)CNOT6
SOURCE (Princeton)CNOT6
Genetics Home Reference (NIH)CNOT6
Genomic and cartography
GoldenPath hg38 (UCSC)CNOT6  -     chr5:180541654-180578357 +  5q35.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CNOT6  -     5q35.3   [Description]    (hg19-Feb_2009)
GoldenPathCNOT6 - 5q35.3 [CytoView hg19]  CNOT6 - 5q35.3 [CytoView hg38]
ImmunoBaseENSG00000113300
genome Data Viewer NCBICNOT6 [Mapview hg19]  
OMIM608951   
Gene and transcription
Genbank (Entrez)AB033020 AI025725 AK023599 AK314752 AL110144
RefSeq transcript (Entrez)NM_001303241 NM_001370472 NM_001370473 NM_001370474 NM_015455
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CNOT6
Alternative Splicing GalleryENSG00000113300
Gene ExpressionCNOT6 [ NCBI-GEO ]   CNOT6 [ EBI - ARRAY_EXPRESS ]   CNOT6 [ SEEK ]   CNOT6 [ MEM ]
Gene Expression Viewer (FireBrowse)CNOT6 [ Firebrowse - Broad ]
GenevisibleExpression of CNOT6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57472
GTEX Portal (Tissue expression)CNOT6
Human Protein AtlasENSG00000113300-CNOT6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9ULM6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9ULM6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9ULM6
Splice isoforms : SwissVarQ9ULM6
PhosPhoSitePlusQ9ULM6
Domaine pattern : Prosite (Expaxy)LRR (PS51450)   
Domains : Interpro (EBI)Cnot6    Endo/exonu/phosph_ase_sf    Endo/exonuclease/phosphatase    Leu-rich_rpt    Leu-rich_rpt_typical-subtyp    LRR_dom_sf   
Domain families : Pfam (Sanger)Exo_endo_phos (PF03372)    LRR_8 (PF13855)   
Domain families : Pfam (NCBI)pfam03372    pfam13855   
Domain families : Smart (EMBL)LRR_TYP (SM00369)  
Conserved Domain (NCBI)CNOT6
Blocks (Seattle)CNOT6
SuperfamilyQ9ULM6
Human Protein Atlas [tissue]ENSG00000113300-CNOT6 [tissue]
Peptide AtlasQ9ULM6
HPRD12341
IPIIPI00008205   IPI00152061   IPI00967167   
Protein Interaction databases
DIP (DOE-UCLA)Q9ULM6
IntAct (EBI)Q9ULM6
BioGRIDCNOT6
STRING (EMBL)CNOT6
ZODIACCNOT6
Ontologies - Pathways
QuickGOQ9ULM6
Ontology : AmiGO3'-5'-exoribonuclease activity  nuclear-transcribed mRNA poly(A) tail shortening  nuclear-transcribed mRNA poly(A) tail shortening  nuclear-transcribed mRNA poly(A) tail shortening  RNA binding  exoribonuclease activity  poly(A)-specific ribonuclease activity  poly(A)-specific ribonuclease activity  poly(A)-specific ribonuclease activity  protein binding  nucleus  cytoplasm  cytosol  regulation of translation  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  positive regulation of cell population proliferation  positive regulation of cytoplasmic mRNA processing body assembly  membrane  CCR4-NOT complex  CCR4-NOT complex  nuclear receptor coactivator activity  gene silencing by miRNA  exonucleolytic catabolism of deadenylated mRNA  positive regulation of transcription, DNA-templated  metal ion binding  nuclear-transcribed mRNA catabolic process, no-go decay  RNA phosphodiester bond hydrolysis, exonucleolytic  
Ontology : EGO-EBI3'-5'-exoribonuclease activity  nuclear-transcribed mRNA poly(A) tail shortening  nuclear-transcribed mRNA poly(A) tail shortening  nuclear-transcribed mRNA poly(A) tail shortening  RNA binding  exoribonuclease activity  poly(A)-specific ribonuclease activity  poly(A)-specific ribonuclease activity  poly(A)-specific ribonuclease activity  protein binding  nucleus  cytoplasm  cytosol  regulation of translation  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  positive regulation of cell population proliferation  positive regulation of cytoplasmic mRNA processing body assembly  membrane  CCR4-NOT complex  CCR4-NOT complex  nuclear receptor coactivator activity  gene silencing by miRNA  exonucleolytic catabolism of deadenylated mRNA  positive regulation of transcription, DNA-templated  metal ion binding  nuclear-transcribed mRNA catabolic process, no-go decay  RNA phosphodiester bond hydrolysis, exonucleolytic  
Pathways : KEGGRNA degradation   
NDEx NetworkCNOT6
Atlas of Cancer Signalling NetworkCNOT6
Wikipedia pathwaysCNOT6
Orthology - Evolution
OrthoDB57472
GeneTree (enSembl)ENSG00000113300
Phylogenetic Trees/Animal Genes : TreeFamCNOT6
HOGENOMQ9ULM6
Homologs : HomoloGeneCNOT6
Homology/Alignments : Family Browser (UCSC)CNOT6
Gene fusions - Rearrangements
Fusion : QuiverCNOT6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCNOT6 [hg38]
dbVarCNOT6
ClinVarCNOT6
MonarchCNOT6
1000_GenomesCNOT6 
Exome Variant ServerCNOT6
GNOMAD BrowserENSG00000113300
Varsome BrowserCNOT6
Genomic Variants (DGV)CNOT6 [DGVbeta]
DECIPHERCNOT6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCNOT6 
Mutations
ICGC Data PortalCNOT6 
TCGA Data PortalCNOT6 
Broad Tumor PortalCNOT6
OASIS PortalCNOT6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCNOT6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCNOT6
Mutations and Diseases : HGMDCNOT6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CNOT6
DgiDB (Drug Gene Interaction Database)CNOT6
DoCM (Curated mutations)CNOT6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CNOT6 (select a term)
intoGenCNOT6
Cancer3DCNOT6(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608951   
Orphanet
DisGeNETCNOT6
MedgenCNOT6
Genetic Testing Registry CNOT6
NextProtQ9ULM6 [Medical]
GENETestsCNOT6
Target ValidationCNOT6
Huge Navigator CNOT6 [HugePedia]
ClinGenCNOT6
Clinical trials, drugs, therapy
MyCancerGenomeCNOT6
Protein Interactions : CTD
Pharm GKB GenePA26677
PharosQ9ULM6
Clinical trialCNOT6
Miscellaneous
canSAR (ICR)CNOT6 (select the gene name)
HarmonizomeCNOT6
DataMed IndexCNOT6
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCNOT6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 25 19:16:16 CET 2021

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