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CNOT6L (CCR4-NOT transcription complex subunit 6 like)

Identity

Alias_namesCCR4-NOT transcription complex
Alias_symbol (synonym)DKFZp434K098
Ccr4b
Other aliasCCR4b
HGNC (Hugo) CNOT6L
LocusID (NCBI) 246175
Atlas_Id 56438
Location 4q21.1  [Link to chromosome band 4q21]
Location_base_pair Starts at 77713387 and ends at 77819390 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CNOT6L (4q21.1) / AKT3 (1q43)CNOT6L (4q21.1) / FRAS1 (4q21.21)KAT6A (8p11.21) / CNOT6L (4q21.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CNOT6L   18042
Cards
Entrez_Gene (NCBI)CNOT6L  246175  CCR4-NOT transcription complex subunit 6 like
AliasesCCR4b
GeneCards (Weizmann)CNOT6L
Ensembl hg19 (Hinxton)ENSG00000138767 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138767 [Gene_View]  chr4:77713387-77819390 [Contig_View]  CNOT6L [Vega]
ICGC DataPortalENSG00000138767
TCGA cBioPortalCNOT6L
AceView (NCBI)CNOT6L
Genatlas (Paris)CNOT6L
WikiGenes246175
SOURCE (Princeton)CNOT6L
Genetics Home Reference (NIH)CNOT6L
Genomic and cartography
GoldenPath hg38 (UCSC)CNOT6L  -     chr4:77713387-77819390 -  4q21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CNOT6L  -     4q21.1   [Description]    (hg19-Feb_2009)
EnsemblCNOT6L - 4q21.1 [CytoView hg19]  CNOT6L - 4q21.1 [CytoView hg38]
Mapping of homologs : NCBICNOT6L [Mapview hg19]  CNOT6L [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK027214 AK058188 AK124855 AK303417 AK304397
RefSeq transcript (Entrez)NM_001286790 NM_144571
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CNOT6L
Cluster EST : UnigeneHs.592519 [ NCBI ]
CGAP (NCI)Hs.592519
Alternative Splicing GalleryENSG00000138767
Gene ExpressionCNOT6L [ NCBI-GEO ]   CNOT6L [ EBI - ARRAY_EXPRESS ]   CNOT6L [ SEEK ]   CNOT6L [ MEM ]
Gene Expression Viewer (FireBrowse)CNOT6L [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)246175
GTEX Portal (Tissue expression)CNOT6L
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96LI5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96LI5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96LI5
Splice isoforms : SwissVarQ96LI5
Catalytic activity : Enzyme3.1.13.4 [ Enzyme-Expasy ]   3.1.13.43.1.13.4 [ IntEnz-EBI ]   3.1.13.4 [ BRENDA ]   3.1.13.4 [ KEGG ]   
PhosPhoSitePlusQ96LI5
Domaine pattern : Prosite (Expaxy)LRR (PS51450)   
Domains : Interpro (EBI)Endo/exonuclease/phosphatase    L_dom-like    Leu-rich_rpt    Leu-rich_rpt_typical-subtyp   
Domain families : Pfam (Sanger)Exo_endo_phos (PF03372)    LRR_8 (PF13855)   
Domain families : Pfam (NCBI)pfam03372    pfam13855   
Domain families : Smart (EMBL)LRR_TYP (SM00369)  
Conserved Domain (NCBI)CNOT6L
DMDM Disease mutations246175
Blocks (Seattle)CNOT6L
PDB (SRS)3NGN    3NGO    3NGQ    5DV2    5DV4   
PDB (PDBSum)3NGN    3NGO    3NGQ    5DV2    5DV4   
PDB (IMB)3NGN    3NGO    3NGQ    5DV2    5DV4   
PDB (RSDB)3NGN    3NGO    3NGQ    5DV2    5DV4   
Structural Biology KnowledgeBase3NGN    3NGO    3NGQ    5DV2    5DV4   
SCOP (Structural Classification of Proteins)3NGN    3NGO    3NGQ    5DV2    5DV4   
CATH (Classification of proteins structures)3NGN    3NGO    3NGQ    5DV2    5DV4   
SuperfamilyQ96LI5
Human Protein AtlasENSG00000138767
Peptide AtlasQ96LI5
HPRD10841
IPIIPI00164061   IPI00878418   IPI00966450   IPI00910740   IPI00967003   IPI01017999   IPI00965534   
Protein Interaction databases
DIP (DOE-UCLA)Q96LI5
IntAct (EBI)Q96LI5
FunCoupENSG00000138767
BioGRIDCNOT6L
STRING (EMBL)CNOT6L
ZODIACCNOT6L
Ontologies - Pathways
QuickGOQ96LI5
Ontology : AmiGOnuclear-transcribed mRNA poly(A) tail shortening  poly(A)-specific ribonuclease activity  protein binding  nucleus  cytoplasm  cytosol  cytosol  transcription, DNA-templated  regulation of transcription, DNA-templated  mRNA processing  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  positive regulation of cell proliferation  positive regulation of cytoplasmic mRNA processing body assembly  CCR4-NOT complex  gene silencing by RNA  metal ion binding  mRNA destabilization  RNA phosphodiester bond hydrolysis, exonucleolytic  
Ontology : EGO-EBInuclear-transcribed mRNA poly(A) tail shortening  poly(A)-specific ribonuclease activity  protein binding  nucleus  cytoplasm  cytosol  cytosol  transcription, DNA-templated  regulation of transcription, DNA-templated  mRNA processing  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  positive regulation of cell proliferation  positive regulation of cytoplasmic mRNA processing body assembly  CCR4-NOT complex  gene silencing by RNA  metal ion binding  mRNA destabilization  RNA phosphodiester bond hydrolysis, exonucleolytic  
Pathways : KEGGRNA degradation   
NDEx NetworkCNOT6L
Atlas of Cancer Signalling NetworkCNOT6L
Wikipedia pathwaysCNOT6L
Orthology - Evolution
OrthoDB246175
GeneTree (enSembl)ENSG00000138767
Phylogenetic Trees/Animal Genes : TreeFamCNOT6L
HOVERGENQ96LI5
HOGENOMQ96LI5
Homologs : HomoloGeneCNOT6L
Homology/Alignments : Family Browser (UCSC)CNOT6L
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCNOT6L [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CNOT6L
dbVarCNOT6L
ClinVarCNOT6L
1000_GenomesCNOT6L 
Exome Variant ServerCNOT6L
ExAC (Exome Aggregation Consortium)CNOT6L (select the gene name)
Genetic variants : HAPMAP246175
Genomic Variants (DGV)CNOT6L [DGVbeta]
DECIPHERCNOT6L [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCNOT6L 
Mutations
ICGC Data PortalCNOT6L 
TCGA Data PortalCNOT6L 
Broad Tumor PortalCNOT6L
OASIS PortalCNOT6L [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCNOT6L  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCNOT6L
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CNOT6L
DgiDB (Drug Gene Interaction Database)CNOT6L
DoCM (Curated mutations)CNOT6L (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CNOT6L (select a term)
intoGenCNOT6L
Cancer3DCNOT6L(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenCNOT6L
Genetic Testing Registry CNOT6L
NextProtQ96LI5 [Medical]
TSGene246175
GENETestsCNOT6L
Huge Navigator CNOT6L [HugePedia]
snp3D : Map Gene to Disease246175
BioCentury BCIQCNOT6L
ClinGenCNOT6L
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD246175
Chemical/Pharm GKB GenePA38480
Clinical trialCNOT6L
Miscellaneous
canSAR (ICR)CNOT6L (select the gene name)
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCNOT6L
EVEXCNOT6L
GoPubMedCNOT6L
iHOPCNOT6L
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:11:10 CEST 2017

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