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CNOT7 (CCR4-NOT transcription complex subunit 7)

Identity

Alias_namesCAF1
CCR4-NOT transcription complex
Other aliasCAF-1
Caf1a
hCAF-1
HGNC (Hugo) CNOT7
LocusID (NCBI) 29883
Atlas_Id 40115
Location 8p22  [Link to chromosome band 8p22]
Location_base_pair Starts at 17231512 and ends at 17246909 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MAT2A (2p11.2) / CNOT7 (8p22)TUBA1B (12q13.12) / CNOT7 (8p22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CNOT7   14101
Cards
Entrez_Gene (NCBI)CNOT7  29883  CCR4-NOT transcription complex subunit 7
AliasesCAF-1; CAF1; Caf1a; hCAF-1
GeneCards (Weizmann)CNOT7
Ensembl hg19 (Hinxton)ENSG00000198791 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198791 [Gene_View]  chr8:17231512-17246909 [Contig_View]  CNOT7 [Vega]
ICGC DataPortalENSG00000198791
TCGA cBioPortalCNOT7
AceView (NCBI)CNOT7
Genatlas (Paris)CNOT7
WikiGenes29883
SOURCE (Princeton)CNOT7
Genetics Home Reference (NIH)CNOT7
Genomic and cartography
GoldenPath hg38 (UCSC)CNOT7  -     chr8:17231512-17246909 -  8p22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CNOT7  -     8p22   [Description]    (hg19-Feb_2009)
EnsemblCNOT7 - 8p22 [CytoView hg19]  CNOT7 - 8p22 [CytoView hg38]
Mapping of homologs : NCBICNOT7 [Mapview hg19]  CNOT7 [Mapview hg38]
OMIM604913   
Gene and transcription
Genbank (Entrez)AA134869 AA165288 AF086915 AK001209 AK021808
RefSeq transcript (Entrez)NM_001322087 NM_001322088 NM_001322089 NM_001322090 NM_001322091 NM_001322092 NM_001322093 NM_001322094 NM_001322095 NM_001322096 NM_001322097 NM_001322098 NM_001322099 NM_001322100 NM_013354 NM_054026
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CNOT7
Cluster EST : UnigeneHs.729775 [ NCBI ]
CGAP (NCI)Hs.729775
Alternative Splicing GalleryENSG00000198791
Gene ExpressionCNOT7 [ NCBI-GEO ]   CNOT7 [ EBI - ARRAY_EXPRESS ]   CNOT7 [ SEEK ]   CNOT7 [ MEM ]
Gene Expression Viewer (FireBrowse)CNOT7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)29883
GTEX Portal (Tissue expression)CNOT7
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UIV1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UIV1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UIV1
Splice isoforms : SwissVarQ9UIV1
Catalytic activity : Enzyme3.1.13.4 [ Enzyme-Expasy ]   3.1.13.43.1.13.4 [ IntEnz-EBI ]   3.1.13.4 [ BRENDA ]   3.1.13.4 [ KEGG ]   
PhosPhoSitePlusQ9UIV1
Domains : Interpro (EBI)RNase_CAF1    RNaseH-like_dom   
Domain families : Pfam (Sanger)CAF1 (PF04857)   
Domain families : Pfam (NCBI)pfam04857   
Conserved Domain (NCBI)CNOT7
DMDM Disease mutations29883
Blocks (Seattle)CNOT7
PDB (SRS)2D5R    4GMJ   
PDB (PDBSum)2D5R    4GMJ   
PDB (IMB)2D5R    4GMJ   
PDB (RSDB)2D5R    4GMJ   
Structural Biology KnowledgeBase2D5R    4GMJ   
SCOP (Structural Classification of Proteins)2D5R    4GMJ   
CATH (Classification of proteins structures)2D5R    4GMJ   
SuperfamilyQ9UIV1
Human Protein AtlasENSG00000198791
Peptide AtlasQ9UIV1
IPIIPI00006552   IPI01011746   IPI00395777   IPI00797153   IPI00978903   IPI01010295   IPI00974478   IPI01009372   
Protein Interaction databases
DIP (DOE-UCLA)Q9UIV1
IntAct (EBI)Q9UIV1
FunCoupENSG00000198791
BioGRIDCNOT7
STRING (EMBL)CNOT7
ZODIACCNOT7
Ontologies - Pathways
QuickGOQ9UIV1
Ontology : AmiGO3'-5'-exoribonuclease activity  nuclear-transcribed mRNA poly(A) tail shortening  deadenylation-dependent decapping of nuclear-transcribed mRNA  P-body  transcription factor activity, sequence-specific DNA binding  RNA binding  exoribonuclease activity  poly(A)-specific ribonuclease activity  signal transducer activity  protein binding  nucleus  cytosol  carbohydrate metabolic process  transcription, DNA-templated  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  signal transduction  positive regulation of cell proliferation  negative regulation of cell proliferation  negative regulation of gene expression  membrane  nuclear body  CCR4-NOT complex  CCR4-NOT complex  gene silencing by RNA  cytoplasmic mRNA processing body assembly  gene silencing by miRNA  exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  positive regulation of nuclear-transcribed mRNA poly(A) tail shortening  positive regulation of mRNA catabolic process  RNA phosphodiester bond hydrolysis, exonucleolytic  positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  
Ontology : EGO-EBI3'-5'-exoribonuclease activity  nuclear-transcribed mRNA poly(A) tail shortening  deadenylation-dependent decapping of nuclear-transcribed mRNA  P-body  transcription factor activity, sequence-specific DNA binding  RNA binding  exoribonuclease activity  poly(A)-specific ribonuclease activity  signal transducer activity  protein binding  nucleus  cytosol  carbohydrate metabolic process  transcription, DNA-templated  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  signal transduction  positive regulation of cell proliferation  negative regulation of cell proliferation  negative regulation of gene expression  membrane  nuclear body  CCR4-NOT complex  CCR4-NOT complex  gene silencing by RNA  cytoplasmic mRNA processing body assembly  gene silencing by miRNA  exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  positive regulation of nuclear-transcribed mRNA poly(A) tail shortening  positive regulation of mRNA catabolic process  RNA phosphodiester bond hydrolysis, exonucleolytic  positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  
Pathways : KEGGRNA degradation   
NDEx NetworkCNOT7
Atlas of Cancer Signalling NetworkCNOT7
Wikipedia pathwaysCNOT7
Orthology - Evolution
OrthoDB29883
GeneTree (enSembl)ENSG00000198791
Phylogenetic Trees/Animal Genes : TreeFamCNOT7
HOVERGENQ9UIV1
HOGENOMQ9UIV1
Homologs : HomoloGeneCNOT7
Homology/Alignments : Family Browser (UCSC)CNOT7
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCNOT7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CNOT7
dbVarCNOT7
ClinVarCNOT7
1000_GenomesCNOT7 
Exome Variant ServerCNOT7
ExAC (Exome Aggregation Consortium)CNOT7 (select the gene name)
Genetic variants : HAPMAP29883
Genomic Variants (DGV)CNOT7 [DGVbeta]
DECIPHERCNOT7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCNOT7 
Mutations
ICGC Data PortalCNOT7 
TCGA Data PortalCNOT7 
Broad Tumor PortalCNOT7
OASIS PortalCNOT7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCNOT7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCNOT7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CNOT7
DgiDB (Drug Gene Interaction Database)CNOT7
DoCM (Curated mutations)CNOT7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CNOT7 (select a term)
intoGenCNOT7
Cancer3DCNOT7(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604913   
Orphanet
MedgenCNOT7
Genetic Testing Registry CNOT7
NextProtQ9UIV1 [Medical]
TSGene29883
GENETestsCNOT7
Target ValidationCNOT7
Huge Navigator CNOT7 [HugePedia]
snp3D : Map Gene to Disease29883
BioCentury BCIQCNOT7
ClinGenCNOT7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD29883
Chemical/Pharm GKB GenePA26678
Clinical trialCNOT7
Miscellaneous
canSAR (ICR)CNOT7 (select the gene name)
Probes
Litterature
PubMed73 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCNOT7
EVEXCNOT7
GoPubMedCNOT7
iHOPCNOT7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:03:04 CEST 2017

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