CNOT8 (CCR4-NOT transcription complex subunit 8)

2003-06-01  

Identity

HGNC
LOCATION
5q33.2
LOCUSID
ALIAS
CAF1,CALIF,Caf1b,POP2,hCAF1
FUSION GENES

Other Information

Locus ID:

NCBI: 9337
MIM: 603731
HGNC: 9207
Ensembl: ENSG00000155508

Variants:

dbSNP: 9337
ClinVar: 9337
TCGA: ENSG00000155508
COSMIC: CNOT8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000155508ENST00000285896Q9UFF9
ENSG00000155508ENST00000403027Q9UFF9
ENSG00000155508ENST00000517568E5RJC5
ENSG00000155508ENST00000517876Q9UFF9
ENSG00000155508ENST00000518028E5RHG0
ENSG00000155508ENST00000518775E5RIL2
ENSG00000155508ENST00000519211E5RJC5
ENSG00000155508ENST00000519394E5RFJ4
ENSG00000155508ENST00000519404Q9UFF9
ENSG00000155508ENST00000519430E5RHG0
ENSG00000155508ENST00000519903E5RIU0
ENSG00000155508ENST00000520472E5RGE4
ENSG00000155508ENST00000520671Q9UFF9
ENSG00000155508ENST00000521450Q9UFF9
ENSG00000155508ENST00000521583Q9UFF9
ENSG00000155508ENST00000521729E5RHD6
ENSG00000155508ENST00000522458E5RHP3
ENSG00000155508ENST00000522644E5RHL9
ENSG00000155508ENST00000523698Q9UFF9
ENSG00000155508ENST00000524105B7Z9U0

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
Deadenylation of mRNAREACTOMER-HSA-429947
TP53 Regulates Transcription of Cell Cycle GenesREACTOMER-HSA-6791312
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertainREACTOMER-HSA-6804115

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
195583672009Human Ccr4-Not complexes contain variable deadenylase subunits.73
205953892010MAPKAP kinase 2 blocks tristetraprolin-directed mRNA decay by inhibiting CAF1 deadenylase recruitment.63
241157692013The SMG5-SMG7 heterodimer directly recruits the CCR4-NOT deadenylase complex to mRNAs containing nonsense codons via interaction with POP2.60
200650432010CCR4-NOT deadenylates mRNA associated with RNA-induced silencing complexes in human cells.54
196055612009The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation.42
229771752012The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex.42
171787842007Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation.33
213362572011Anti-proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylase.27
232364732012The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex.25
205953942010Quantitative characterization of Tob interactions provides the thermodynamic basis for translation termination-coupled deadenylase regulation.11

Citation

Dessen P

CNOT8 (CCR4-NOT transcription complex subunit 8)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40116/cnot8