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CNOT8 (CCR4-NOT transcription complex subunit 8)

Identity

Alias_namesPOP2
CCR4-NOT transcription complex
Alias_symbol (synonym)CAF1
hCAF1
CALIF
Other aliasCaf1b
HGNC (Hugo) CNOT8
LocusID (NCBI) 9337
Atlas_Id 40116
Location 5q33.2  [Link to chromosome band 5q33]
Location_base_pair Starts at 154238079 and ends at 154256352 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CNOT8 (5q33.2) / GOLGB1 (3q13.33)JUND (19p13.11) / CNOT8 (5q33.2)MALAT1 (11q13.1) / CNOT8 (5q33.2)
PLEKHA6 (1q32.1) / CNOT8 (5q33.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CNOT8   9207
Cards
Entrez_Gene (NCBI)CNOT8  9337  CCR4-NOT transcription complex subunit 8
AliasesCAF1; CALIF; Caf1b; POP2; 
hCAF1
GeneCards (Weizmann)CNOT8
Ensembl hg19 (Hinxton)ENSG00000155508 [Gene_View]  chr5:154238079-154256352 [Contig_View]  CNOT8 [Vega]
Ensembl hg38 (Hinxton)ENSG00000155508 [Gene_View]  chr5:154238079-154256352 [Contig_View]  CNOT8 [Vega]
ICGC DataPortalENSG00000155508
TCGA cBioPortalCNOT8
AceView (NCBI)CNOT8
Genatlas (Paris)CNOT8
WikiGenes9337
SOURCE (Princeton)CNOT8
Genetics Home Reference (NIH)CNOT8
Genomic and cartography
GoldenPath hg19 (UCSC)CNOT8  -     chr5:154238079-154256352 +  5q33.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CNOT8  -     5q33.2   [Description]    (hg38-Dec_2013)
EnsemblCNOT8 - 5q33.2 [CytoView hg19]  CNOT8 - 5q33.2 [CytoView hg38]
Mapping of homologs : NCBICNOT8 [Mapview hg19]  CNOT8 [Mapview hg38]
OMIM603731   
Gene and transcription
Genbank (Entrez)AF053318 AF087844 AF180476 AK025358 AK297381
RefSeq transcript (Entrez)NM_001301073 NM_001301074 NM_001301075 NM_001301077 NM_001301080 NM_001301082 NM_001301083 NM_001301086 NM_004779
RefSeq genomic (Entrez)NC_000005 NC_018916 NT_029289 NW_004929324
Consensus coding sequences : CCDS (NCBI)CNOT8
Cluster EST : UnigeneHs.26703 [ NCBI ]
CGAP (NCI)Hs.26703
Alternative Splicing GalleryENSG00000155508
Gene ExpressionCNOT8 [ NCBI-GEO ]   CNOT8 [ EBI - ARRAY_EXPRESS ]   CNOT8 [ SEEK ]   CNOT8 [ MEM ]
Gene Expression Viewer (FireBrowse)CNOT8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9337
GTEX Portal (Tissue expression)CNOT8
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UFF9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UFF9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UFF9
Splice isoforms : SwissVarQ9UFF9
Catalytic activity : Enzyme3.1.13.4 [ Enzyme-Expasy ]   3.1.13.43.1.13.4 [ IntEnz-EBI ]   3.1.13.4 [ BRENDA ]   3.1.13.4 [ KEGG ]   
PhosPhoSitePlusQ9UFF9
Domains : Interpro (EBI)Cnot8    RNase_CAF1    RNaseH-like_dom   
Domain families : Pfam (Sanger)CAF1 (PF04857)   
Domain families : Pfam (NCBI)pfam04857   
Conserved Domain (NCBI)CNOT8
DMDM Disease mutations9337
Blocks (Seattle)CNOT8
SuperfamilyQ9UFF9
Human Protein AtlasENSG00000155508
Peptide AtlasQ9UFF9
HPRD07225
IPIIPI00295501   IPI01011683   IPI00976721   IPI00981605   IPI00984192   IPI00977360   IPI00978233   IPI00979467   IPI00982113   IPI00981542   IPI00980211   IPI00984764   IPI00974190   IPI00982993   IPI00976222   
Protein Interaction databases
DIP (DOE-UCLA)Q9UFF9
IntAct (EBI)Q9UFF9
FunCoupENSG00000155508
BioGRIDCNOT8
STRING (EMBL)CNOT8
ZODIACCNOT8
Ontologies - Pathways
QuickGOQ9UFF9
Ontology : AmiGO3'-5'-exoribonuclease activity  nuclear-transcribed mRNA poly(A) tail shortening  transcription factor activity, sequence-specific DNA binding  RNA binding  poly(A)-specific ribonuclease activity  protein binding  intracellular  nucleus  cytosol  transcription, DNA-templated  regulation of transcription, DNA-templated  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  positive regulation of cell proliferation  negative regulation of cell proliferation  CCR4-NOT complex  gene silencing by miRNA  exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay  metal ion binding  positive regulation of mRNA catabolic process  RNA phosphodiester bond hydrolysis, exonucleolytic  RNA phosphodiester bond hydrolysis, exonucleolytic  
Ontology : EGO-EBI3'-5'-exoribonuclease activity  nuclear-transcribed mRNA poly(A) tail shortening  transcription factor activity, sequence-specific DNA binding  RNA binding  poly(A)-specific ribonuclease activity  protein binding  intracellular  nucleus  cytosol  transcription, DNA-templated  regulation of transcription, DNA-templated  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  positive regulation of cell proliferation  negative regulation of cell proliferation  CCR4-NOT complex  gene silencing by miRNA  exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay  metal ion binding  positive regulation of mRNA catabolic process  RNA phosphodiester bond hydrolysis, exonucleolytic  RNA phosphodiester bond hydrolysis, exonucleolytic  
Pathways : KEGGRNA degradation   
NDEx NetworkCNOT8
Atlas of Cancer Signalling NetworkCNOT8
Wikipedia pathwaysCNOT8
Orthology - Evolution
OrthoDB9337
GeneTree (enSembl)ENSG00000155508
Phylogenetic Trees/Animal Genes : TreeFamCNOT8
HOVERGENQ9UFF9
HOGENOMQ9UFF9
Homologs : HomoloGeneCNOT8
Homology/Alignments : Family Browser (UCSC)CNOT8
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCNOT8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CNOT8
dbVarCNOT8
ClinVarCNOT8
1000_GenomesCNOT8 
Exome Variant ServerCNOT8
ExAC (Exome Aggregation Consortium)CNOT8 (select the gene name)
Genetic variants : HAPMAP9337
Genomic Variants (DGV)CNOT8 [DGVbeta]
DECIPHER (Syndromes)5:154238079-154256352  ENSG00000155508
CONAN: Copy Number AnalysisCNOT8 
Mutations
ICGC Data PortalCNOT8 
TCGA Data PortalCNOT8 
Broad Tumor PortalCNOT8
OASIS PortalCNOT8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCNOT8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCNOT8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CNOT8
DgiDB (Drug Gene Interaction Database)CNOT8
DoCM (Curated mutations)CNOT8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CNOT8 (select a term)
intoGenCNOT8
Cancer3DCNOT8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603731   
Orphanet
MedgenCNOT8
Genetic Testing Registry CNOT8
NextProtQ9UFF9 [Medical]
TSGene9337
GENETestsCNOT8
Huge Navigator CNOT8 [HugePedia]
snp3D : Map Gene to Disease9337
BioCentury BCIQCNOT8
ClinGenCNOT8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9337
Chemical/Pharm GKB GenePA26679
Clinical trialCNOT8
Miscellaneous
canSAR (ICR)CNOT8 (select the gene name)
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCNOT8
EVEXCNOT8
GoPubMedCNOT8
iHOPCNOT8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Mar 30 14:57:04 CEST 2017

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