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CNR2 (cannabinoid receptor 2)

Identity

Alias_namescannabinoid receptor 2 (macrophage)
Alias_symbol (synonym)CB2
Other aliasCB-2
CX5
HGNC (Hugo) CNR2
LocusID (NCBI) 1269
Atlas_Id 43813
Location 1p36.11  [Link to chromosome band 1p36]
Location_base_pair Starts at 24200460 and ends at 24239817 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
BTBD6 (14q32.33) / CNR2 (1p36.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CNR2   2160
Cards
Entrez_Gene (NCBI)CNR2  1269  cannabinoid receptor 2
AliasesCB-2; CB2; CX5
GeneCards (Weizmann)CNR2
Ensembl hg19 (Hinxton)ENSG00000188822 [Gene_View]  chr1:24200460-24239817 [Contig_View]  CNR2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000188822 [Gene_View]  chr1:24200460-24239817 [Contig_View]  CNR2 [Vega]
ICGC DataPortalENSG00000188822
TCGA cBioPortalCNR2
AceView (NCBI)CNR2
Genatlas (Paris)CNR2
WikiGenes1269
SOURCE (Princeton)CNR2
Genetics Home Reference (NIH)CNR2
Genomic and cartography
GoldenPath hg19 (UCSC)CNR2  -     chr1:24200460-24239817 -  1p36.11   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CNR2  -     1p36.11   [Description]    (hg38-Dec_2013)
EnsemblCNR2 - 1p36.11 [CytoView hg19]  CNR2 - 1p36.11 [CytoView hg38]
Mapping of homologs : NCBICNR2 [Mapview hg19]  CNR2 [Mapview hg38]
OMIM605051   
Gene and transcription
Genbank (Entrez)AJ430063 AM156854 AM156855 AM156856 BC069722
RefSeq transcript (Entrez)NM_001841
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_032977 NW_004929289
Consensus coding sequences : CCDS (NCBI)CNR2
Cluster EST : UnigeneHs.73037 [ NCBI ]
CGAP (NCI)Hs.73037
Alternative Splicing GalleryENSG00000188822
Gene ExpressionCNR2 [ NCBI-GEO ]   CNR2 [ EBI - ARRAY_EXPRESS ]   CNR2 [ SEEK ]   CNR2 [ MEM ]
Gene Expression Viewer (FireBrowse)CNR2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1269
GTEX Portal (Tissue expression)CNR2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP34972   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP34972  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP34972
Splice isoforms : SwissVarP34972
PhosPhoSitePlusP34972
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)Canbinoid_rcpt_2    Cnbnoid_rcpt    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)CNR2
DMDM Disease mutations1269
Blocks (Seattle)CNR2
PDB (SRS)2KI9   
PDB (PDBSum)2KI9   
PDB (IMB)2KI9   
PDB (RSDB)2KI9   
Structural Biology KnowledgeBase2KI9   
SCOP (Structural Classification of Proteins)2KI9   
CATH (Classification of proteins structures)2KI9   
SuperfamilyP34972
Human Protein AtlasENSG00000188822
Peptide AtlasP34972
HPRD05444
IPIIPI00003060   IPI00982050   
Protein Interaction databases
DIP (DOE-UCLA)P34972
IntAct (EBI)P34972
FunCoupENSG00000188822
BioGRIDCNR2
STRING (EMBL)CNR2
ZODIACCNR2
Ontologies - Pathways
QuickGOP34972
Ontology : AmiGOresponse to amphetamine  cannabinoid receptor activity  plasma membrane  integral component of plasma membrane  inflammatory response  immune response  G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  sensory perception of pain  dendrite  extrinsic component of cytoplasmic side of plasma membrane  negative regulation of synaptic transmission, GABAergic  response to lipopolysaccharide  negative regulation of mast cell activation  cannabinoid signaling pathway  perikaryon  negative regulation of action potential  negative regulation of inflammatory response  negative regulation of nitric-oxide synthase activity  
Ontology : EGO-EBIresponse to amphetamine  cannabinoid receptor activity  plasma membrane  integral component of plasma membrane  inflammatory response  immune response  G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  sensory perception of pain  dendrite  extrinsic component of cytoplasmic side of plasma membrane  negative regulation of synaptic transmission, GABAergic  response to lipopolysaccharide  negative regulation of mast cell activation  cannabinoid signaling pathway  perikaryon  negative regulation of action potential  negative regulation of inflammatory response  negative regulation of nitric-oxide synthase activity  
Pathways : BIOCARTAMetabolism of Anandamide, an Endogenous Cannabinoid [Genes]   
Pathways : KEGGNeuroactive ligand-receptor interaction   
NDEx NetworkCNR2
Atlas of Cancer Signalling NetworkCNR2
Wikipedia pathwaysCNR2
Orthology - Evolution
OrthoDB1269
GeneTree (enSembl)ENSG00000188822
Phylogenetic Trees/Animal Genes : TreeFamCNR2
HOVERGENP34972
HOGENOMP34972
Homologs : HomoloGeneCNR2
Homology/Alignments : Family Browser (UCSC)CNR2
Gene fusions - Rearrangements
Fusion Cancer (Beijing)BTBD6 [14q32.33]  -  CNR2 [1p36.11]  [FUSC004661]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCNR2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CNR2
dbVarCNR2
ClinVarCNR2
1000_GenomesCNR2 
Exome Variant ServerCNR2
ExAC (Exome Aggregation Consortium)CNR2 (select the gene name)
Genetic variants : HAPMAP1269
Genomic Variants (DGV)CNR2 [DGVbeta]
DECIPHER (Syndromes)1:24200460-24239817  ENSG00000188822
CONAN: Copy Number AnalysisCNR2 
Mutations
ICGC Data PortalCNR2 
TCGA Data PortalCNR2 
Broad Tumor PortalCNR2
OASIS PortalCNR2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCNR2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCNR2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CNR2
DgiDB (Drug Gene Interaction Database)CNR2
DoCM (Curated mutations)CNR2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CNR2 (select a term)
intoGenCNR2
Cancer3DCNR2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605051   
Orphanet
MedgenCNR2
Genetic Testing Registry CNR2
NextProtP34972 [Medical]
TSGene1269
GENETestsCNR2
Huge Navigator CNR2 [HugePedia]
snp3D : Map Gene to Disease1269
BioCentury BCIQCNR2
ClinGenCNR2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1269
Chemical/Pharm GKB GenePA26682
Clinical trialCNR2
Miscellaneous
canSAR (ICR)CNR2 (select the gene name)
Probes
Litterature
PubMed172 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCNR2
EVEXCNR2
GoPubMedCNR2
iHOPCNR2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Mar 30 14:57:05 CEST 2017

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