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CNTF (ciliary neurotrophic factor)

Identity

Alias_symbol (synonym)HCNTF
Other alias
HGNC (Hugo) CNTF
LocusID (NCBI) 1270
Atlas_Id 46302
Location 11q12.1  [Link to chromosome band 11q12]
Location_base_pair Starts at 58390146 and ends at 58393205 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ZFP91 (11q12.1) / CNTF (11q12.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CNTF   2169
Cards
Entrez_Gene (NCBI)CNTF  1270  ciliary neurotrophic factor
AliasesHCNTF
GeneCards (Weizmann)CNTF
Ensembl hg19 (Hinxton)ENSG00000242689 [Gene_View]  chr11:58390146-58393205 [Contig_View]  CNTF [Vega]
Ensembl hg38 (Hinxton)ENSG00000242689 [Gene_View]  chr11:58390146-58393205 [Contig_View]  CNTF [Vega]
ICGC DataPortalENSG00000242689
TCGA cBioPortalCNTF
AceView (NCBI)CNTF
Genatlas (Paris)CNTF
WikiGenes1270
SOURCE (Princeton)CNTF
Genetics Home Reference (NIH)CNTF
Genomic and cartography
GoldenPath hg19 (UCSC)CNTF  -     chr11:58390146-58393205 +  11q12.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CNTF  -     11q12.1   [Description]    (hg38-Dec_2013)
EnsemblCNTF - 11q12.1 [CytoView hg19]  CNTF - 11q12.1 [CytoView hg38]
Mapping of homologs : NCBICNTF [Mapview hg19]  CNTF [Mapview hg38]
OMIM118945   
Gene and transcription
Genbank (Entrez)AK314118 BC068030 BC069167 BC074963 BC074964
RefSeq transcript (Entrez)NM_000614
RefSeq genomic (Entrez)NC_000011 NC_018922 NG_008776 NT_167190 NW_004929380
Consensus coding sequences : CCDS (NCBI)CNTF
Cluster EST : UnigeneHs.524920 [ NCBI ]
CGAP (NCI)Hs.524920
Alternative Splicing GalleryENSG00000242689
Gene ExpressionCNTF [ NCBI-GEO ]   CNTF [ EBI - ARRAY_EXPRESS ]   CNTF [ SEEK ]   CNTF [ MEM ]
Gene Expression Viewer (FireBrowse)CNTF [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1270
GTEX Portal (Tissue expression)CNTF
Protein : pattern, domain, 3D structure
UniProt/SwissProtP26441   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP26441  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP26441
Splice isoforms : SwissVarP26441
PhosPhoSitePlusP26441
Domains : Interpro (EBI)4_helix_cytokine-like_core    4_helix_cytokine_core    Ciliary_neurotrophic_fac_CNTF   
Domain families : Pfam (Sanger)CNTF (PF01110)   
Domain families : Pfam (NCBI)pfam01110   
Conserved Domain (NCBI)CNTF
DMDM Disease mutations1270
Blocks (Seattle)CNTF
PDB (SRS)1CNT   
PDB (PDBSum)1CNT   
PDB (IMB)1CNT   
PDB (RSDB)1CNT   
Structural Biology KnowledgeBase1CNT   
SCOP (Structural Classification of Proteins)1CNT   
CATH (Classification of proteins structures)1CNT   
SuperfamilyP26441
Human Protein AtlasENSG00000242689
Peptide AtlasP26441
HPRD00347
IPIIPI00032298   
Protein Interaction databases
DIP (DOE-UCLA)P26441
IntAct (EBI)P26441
FunCoupENSG00000242689
BioGRIDCNTF
STRING (EMBL)CNTF
ZODIACCNTF
Ontologies - Pathways
QuickGOP26441
Ontology : AmiGOcytokine activity  ciliary neurotrophic factor receptor binding  interleukin-6 receptor binding  protein binding  extracellular region  extracellular space  cytoplasm  signal transduction  growth factor activity  positive regulation of cell proliferation  positive regulation of gene expression  axon  growth  positive regulation of tyrosine phosphorylation of Stat3 protein  negative regulation of neuron apoptotic process  negative regulation of photoreceptor cell differentiation  regulation of retinal cell programmed cell death  astrocyte activation  muscle organ morphogenesis  neuron development  positive regulation of axon regeneration  ciliary neurotrophic factor-mediated signaling pathway  CRLF-CLCF1 complex  
Ontology : EGO-EBIcytokine activity  ciliary neurotrophic factor receptor binding  interleukin-6 receptor binding  protein binding  extracellular region  extracellular space  cytoplasm  signal transduction  growth factor activity  positive regulation of cell proliferation  positive regulation of gene expression  axon  growth  positive regulation of tyrosine phosphorylation of Stat3 protein  negative regulation of neuron apoptotic process  negative regulation of photoreceptor cell differentiation  regulation of retinal cell programmed cell death  astrocyte activation  muscle organ morphogenesis  neuron development  positive regulation of axon regeneration  ciliary neurotrophic factor-mediated signaling pathway  CRLF-CLCF1 complex  
Pathways : KEGGCytokine-cytokine receptor interaction    Jak-STAT signaling pathway   
NDEx NetworkCNTF
Atlas of Cancer Signalling NetworkCNTF
Wikipedia pathwaysCNTF
Orthology - Evolution
OrthoDB1270
GeneTree (enSembl)ENSG00000242689
Phylogenetic Trees/Animal Genes : TreeFamCNTF
HOVERGENP26441
HOGENOMP26441
Homologs : HomoloGeneCNTF
Homology/Alignments : Family Browser (UCSC)CNTF
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCNTF [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CNTF
dbVarCNTF
ClinVarCNTF
1000_GenomesCNTF 
Exome Variant ServerCNTF
ExAC (Exome Aggregation Consortium)CNTF (select the gene name)
Genetic variants : HAPMAP1270
Genomic Variants (DGV)CNTF [DGVbeta]
DECIPHER (Syndromes)11:58390146-58393205  ENSG00000242689
CONAN: Copy Number AnalysisCNTF 
Mutations
ICGC Data PortalCNTF 
TCGA Data PortalCNTF 
Broad Tumor PortalCNTF
OASIS PortalCNTF [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCNTF  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCNTF
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CNTF
DgiDB (Drug Gene Interaction Database)CNTF
DoCM (Curated mutations)CNTF (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CNTF (select a term)
intoGenCNTF
Cancer3DCNTF(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM118945   
Orphanet
MedgenCNTF
Genetic Testing Registry CNTF
NextProtP26441 [Medical]
TSGene1270
GENETestsCNTF
Huge Navigator CNTF [HugePedia]
snp3D : Map Gene to Disease1270
BioCentury BCIQCNTF
ClinGenCNTF
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1270
Chemical/Pharm GKB GenePA26683
Clinical trialCNTF
Miscellaneous
canSAR (ICR)CNTF (select the gene name)
Probes
Litterature
PubMed89 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCNTF
EVEXCNTF
GoPubMedCNTF
iHOPCNTF
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:01:06 CET 2017

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