CNTN1 (contactin 1)

2003-08-01  

Identity

HGNC
LOCATION
12q12
LOCUSID
ALIAS
F3,GP135,MYPCN
FUSION GENES

Other Information

Locus ID:

NCBI: 1272
MIM: 600016
HGNC: 2171
Ensembl: ENSG00000018236

Variants:

dbSNP: 1272
ClinVar: 1272
TCGA: ENSG00000018236
COSMIC: CNTN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000018236ENST00000347616Q12860
ENSG00000018236ENST00000347616A0A024R104
ENSG00000018236ENST00000348761Q12860
ENSG00000018236ENST00000547702Q12860
ENSG00000018236ENST00000547849Q12860
ENSG00000018236ENST00000548005F8VUI8
ENSG00000018236ENST00000548481H0YIJ1
ENSG00000018236ENST00000551295Q12860
ENSG00000018236ENST00000551295A0A024R104
ENSG00000018236ENST00000551424F8VQW3
ENSG00000018236ENST00000552248F8VUI9
ENSG00000018236ENST00000552913F8VX96

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Cell adhesion molecules (CAMs)KEGGhsa04514
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Signaling by NOTCH1REACTOMER-HSA-1980143
Activated NOTCH1 Transmits Signal to the NucleusREACTOMER-HSA-2122948
Signaling by NOTCH2REACTOMER-HSA-1980145
NOTCH2 Activation and Transmission of Signal to the NucleusREACTOMER-HSA-2979096
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
L1CAM interactionsREACTOMER-HSA-373760
Neurofascin interactionsREACTOMER-HSA-447043

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
145679142003F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation.115
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
219695502011A complex between contactin-1 and the protein tyrosine phosphatase PTPRZ controls the development of oligodendrocyte precursor cells.34
190263982008Mutations in contactin-1, a neural adhesion and neuromuscular junction protein, cause a familial form of lethal congenital myopathy.27
258083732015Contactin 1 IgG4 associates to chronic inflammatory demyelinating polyneuropathy with sensory ataxia.25
214824722011VEGF-C promotes the development of esophageal cancer via regulating CNTN-1 expression.19
267953492016Neural Cell Adhesion Protein CNTN1 Promotes the Metastatic Progression of Prostate Cancer.14
223609682012F3/Contactin acts as a modulator of neurogenesis during cerebral cortex development.12
259525822015Significances of contactin-1 expression in human gastric cancer and knockdown of contactin-1 expression inhibits invasion and metastasis of MKN45 gastric cancer cells.12

Citation

Dessen P

CNTN1 (contactin 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40117/cntn1