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CNTN2 (contactin 2)

Identity

Alias_namesTAX
AXT
contactin 2 (axonal)
Alias_symbol (synonym)TAG-1
TAX1
Other aliasFAME5
HGNC (Hugo) CNTN2
LocusID (NCBI) 6900
Atlas_Id 40118
Location 1q32.1  [Link to chromosome band 1q32]
Location_base_pair Starts at 205012340 and ends at 205047171 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
EDRF1 (10q26.13) / CNTN2 (1q32.1)MAT2A (2p11.2) / CNTN2 (1q32.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CNTN2   2172
Cards
Entrez_Gene (NCBI)CNTN2  6900  contactin 2
AliasesAXT; FAME5; TAG-1; TAX; 
TAX1
GeneCards (Weizmann)CNTN2
Ensembl hg19 (Hinxton)ENSG00000184144 [Gene_View]  chr1:205012340-205047171 [Contig_View]  CNTN2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000184144 [Gene_View]  chr1:205012340-205047171 [Contig_View]  CNTN2 [Vega]
ICGC DataPortalENSG00000184144
TCGA cBioPortalCNTN2
AceView (NCBI)CNTN2
Genatlas (Paris)CNTN2
WikiGenes6900
SOURCE (Princeton)CNTN2
Genetics Home Reference (NIH)CNTN2
Genomic and cartography
GoldenPath hg19 (UCSC)CNTN2  -     chr1:205012340-205047171 +  1q32.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CNTN2  -     1q32.1   [Description]    (hg38-Dec_2013)
EnsemblCNTN2 - 1q32.1 [CytoView hg19]  CNTN2 - 1q32.1 [CytoView hg38]
Mapping of homologs : NCBICNTN2 [Mapview hg19]  CNTN2 [Mapview hg38]
OMIM190197   615400   
Gene and transcription
Genbank (Entrez)AB074271 AK095531 AK124736 AK289985 AK309108
RefSeq transcript (Entrez)NM_005076
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_033845 NT_004487 NW_004929293
Consensus coding sequences : CCDS (NCBI)CNTN2
Cluster EST : UnigeneHs.519220 [ NCBI ]
CGAP (NCI)Hs.519220
Alternative Splicing GalleryENSG00000184144
Gene ExpressionCNTN2 [ NCBI-GEO ]   CNTN2 [ EBI - ARRAY_EXPRESS ]   CNTN2 [ SEEK ]   CNTN2 [ MEM ]
Gene Expression Viewer (FireBrowse)CNTN2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6900
GTEX Portal (Tissue expression)CNTN2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ02246   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ02246  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ02246
Splice isoforms : SwissVarQ02246
PhosPhoSitePlusQ02246
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    IG_LIKE (PS50835)   
Domains : Interpro (EBI)Contactin-2    FN3_dom    Ig-like_dom    Ig-like_fold    Ig_I-set    Ig_sub    Ig_sub2    Immunoglobulin   
Domain families : Pfam (Sanger)fn3 (PF00041)    I-set (PF07679)    ig (PF00047)   
Domain families : Pfam (NCBI)pfam00041    pfam07679    pfam00047   
Domain families : Smart (EMBL)FN3 (SM00060)  IG (SM00409)  IGc2 (SM00408)  
Conserved Domain (NCBI)CNTN2
DMDM Disease mutations6900
Blocks (Seattle)CNTN2
PDB (SRS)2OM5   
PDB (PDBSum)2OM5   
PDB (IMB)2OM5   
PDB (RSDB)2OM5   
Structural Biology KnowledgeBase2OM5   
SCOP (Structural Classification of Proteins)2OM5   
CATH (Classification of proteins structures)2OM5   
SuperfamilyQ02246
Human Protein AtlasENSG00000184144
Peptide AtlasQ02246
HPRD01826
IPIIPI00024966   
Protein Interaction databases
DIP (DOE-UCLA)Q02246
IntAct (EBI)Q02246
FunCoupENSG00000184144
BioGRIDCNTN2
STRING (EMBL)CNTN2
ZODIACCNTN2
Ontologies - Pathways
QuickGOQ02246
Ontology : AmiGOmicrotubule cytoskeleton organization  glycoprotein binding  plasma membrane  integral component of plasma membrane  cell adhesion  cell-matrix adhesion  axon guidance  axonal fasciculation  learning  adult walking behavior  voltage-gated potassium channel complex  cell surface  positive regulation of protein processing  cerebral cortex GABAergic interneuron migration  central nervous system myelination  carbohydrate binding  regulation of axon diameter  anchored component of membrane  receptor internalization  node of Ranvier  identical protein binding  neuronal cell body  myelin sheath  protein self-association  juxtaparanode region of axon  clustering of voltage-gated potassium channels  synapse  negative regulation of neuron differentiation  regulation of neuronal synaptic plasticity  regulation of astrocyte differentiation  positive regulation of adenosine receptor signaling pathway  protein localization to juxtaparanode region of axon  establishment of protein localization to juxtaparanode region of axon  presynaptic membrane organization  
Ontology : EGO-EBImicrotubule cytoskeleton organization  glycoprotein binding  plasma membrane  integral component of plasma membrane  cell adhesion  cell-matrix adhesion  axon guidance  axonal fasciculation  learning  adult walking behavior  voltage-gated potassium channel complex  cell surface  positive regulation of protein processing  cerebral cortex GABAergic interneuron migration  central nervous system myelination  carbohydrate binding  regulation of axon diameter  anchored component of membrane  receptor internalization  node of Ranvier  identical protein binding  neuronal cell body  myelin sheath  protein self-association  juxtaparanode region of axon  clustering of voltage-gated potassium channels  synapse  negative regulation of neuron differentiation  regulation of neuronal synaptic plasticity  regulation of astrocyte differentiation  positive regulation of adenosine receptor signaling pathway  protein localization to juxtaparanode region of axon  establishment of protein localization to juxtaparanode region of axon  presynaptic membrane organization  
Pathways : KEGGCell adhesion molecules (CAMs)   
NDEx NetworkCNTN2
Atlas of Cancer Signalling NetworkCNTN2
Wikipedia pathwaysCNTN2
Orthology - Evolution
OrthoDB6900
GeneTree (enSembl)ENSG00000184144
Phylogenetic Trees/Animal Genes : TreeFamCNTN2
HOVERGENQ02246
HOGENOMQ02246
Homologs : HomoloGeneCNTN2
Homology/Alignments : Family Browser (UCSC)CNTN2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCNTN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CNTN2
dbVarCNTN2
ClinVarCNTN2
1000_GenomesCNTN2 
Exome Variant ServerCNTN2
ExAC (Exome Aggregation Consortium)CNTN2 (select the gene name)
Genetic variants : HAPMAP6900
Genomic Variants (DGV)CNTN2 [DGVbeta]
DECIPHER (Syndromes)1:205012340-205047171  ENSG00000184144
CONAN: Copy Number AnalysisCNTN2 
Mutations
ICGC Data PortalCNTN2 
TCGA Data PortalCNTN2 
Broad Tumor PortalCNTN2
OASIS PortalCNTN2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCNTN2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCNTN2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CNTN2
DgiDB (Drug Gene Interaction Database)CNTN2
DoCM (Curated mutations)CNTN2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CNTN2 (select a term)
intoGenCNTN2
Cancer3DCNTN2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM190197    615400   
Orphanet11734   
MedgenCNTN2
Genetic Testing Registry CNTN2
NextProtQ02246 [Medical]
TSGene6900
GENETestsCNTN2
Huge Navigator CNTN2 [HugePedia]
snp3D : Map Gene to Disease6900
BioCentury BCIQCNTN2
ClinGenCNTN2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6900
Chemical/Pharm GKB GenePA26686
Clinical trialCNTN2
Miscellaneous
canSAR (ICR)CNTN2 (select the gene name)
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCNTN2
EVEXCNTN2
GoPubMedCNTN2
iHOPCNTN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:01:07 CET 2017

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