Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

CNTN4 (contactin 4)

Identity

Alias (NCBI)AXCAM
BIG-2
HGNC (Hugo) CNTN4
HGNC Alias symbBIG-2
LocusID (NCBI) 152330
Atlas_Id 51225
Location 3p26.2  [Link to chromosome band 3p26]
Location_base_pair Starts at 2892215 and ends at 3057961 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CNTN4 (3p26.3) / B3GNT2 (2p15)CNTN4 (3p26.3) / LINC00341 (14q32.13)CNTN4 (3p26.3) / RASA3 (13q34)
RSF1 (11q14.1) / CNTN4 (3p26.3)SLC1A5 (19q13.32) / CNTN4 (3p26.3)SNX21 (20q13.12) / CNTN4 (3p26.3)
TLK1 (2q31.1) / CNTN4 (3p26.3)TRNT1 (3p26.2) / CNTN4 (3p26.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(3;11)(p26;q14) RSF1/CNTN4

External links

Nomenclature
HGNC (Hugo)CNTN4   2174
Cards
Entrez_Gene (NCBI)CNTN4    contactin 4
AliasesAXCAM; BIG-2
GeneCards (Weizmann)CNTN4
Ensembl hg19 (Hinxton)ENSG00000144619 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000144619 [Gene_View]  ENSG00000144619 [Sequence]  chr3:2892215-3057961 [Contig_View]  CNTN4 [Vega]
ICGC DataPortalENSG00000144619
TCGA cBioPortalCNTN4
AceView (NCBI)CNTN4
Genatlas (Paris)CNTN4
SOURCE (Princeton)CNTN4
Genetics Home Reference (NIH)CNTN4
Genomic and cartography
GoldenPath hg38 (UCSC)CNTN4  -     chr3:2892215-3057961 +  3p26.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CNTN4  -     3p26.2   [Description]    (hg19-Feb_2009)
GoldenPathCNTN4 - 3p26.2 [CytoView hg19]  CNTN4 - 3p26.2 [CytoView hg38]
ImmunoBaseENSG00000144619
genome Data Viewer NCBICNTN4 [Mapview hg19]  
OMIM607280   
Gene and transcription
Genbank (Entrez)AF464063 AF549455 AI022097 AK057278 AK095729
RefSeq transcript (Entrez)NM_001206955 NM_001206956 NM_001350095 NM_175607 NM_175612 NM_175613
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CNTN4
Alternative Splicing GalleryENSG00000144619
Gene ExpressionCNTN4 [ NCBI-GEO ]   CNTN4 [ EBI - ARRAY_EXPRESS ]   CNTN4 [ SEEK ]   CNTN4 [ MEM ]
Gene Expression Viewer (FireBrowse)CNTN4 [ Firebrowse - Broad ]
GenevisibleExpression of CNTN4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)152330
GTEX Portal (Tissue expression)CNTN4
Human Protein AtlasENSG00000144619-CNTN4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IWV2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IWV2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IWV2
Splice isoforms : SwissVarQ8IWV2
PhosPhoSitePlusQ8IWV2
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    IG_LIKE (PS50835)   
Domains : Interpro (EBI)Contactin-4    FN3_dom    FN3_sf    Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig_I-set    Ig_sub    Ig_sub2   
Domain families : Pfam (Sanger)fn3 (PF00041)    I-set (PF07679)   
Domain families : Pfam (NCBI)pfam00041    pfam07679   
Domain families : Smart (EMBL)FN3 (SM00060)  IG (SM00409)  IGc2 (SM00408)  
Conserved Domain (NCBI)CNTN4
Blocks (Seattle)CNTN4
SuperfamilyQ8IWV2
Human Protein Atlas [tissue]ENSG00000144619-CNTN4 [tissue]
Peptide AtlasQ8IWV2
HPRD16239
IPIIPI00178854   IPI00479016   IPI00941807   IPI00744041   IPI00927871   IPI00925010   IPI00924784   IPI00927340   IPI00967151   
Protein Interaction databases
DIP (DOE-UCLA)Q8IWV2
IntAct (EBI)Q8IWV2
BioGRIDCNTN4
STRING (EMBL)CNTN4
ZODIACCNTN4
Ontologies - Pathways
QuickGOQ8IWV2
Ontology : AmiGOextracellular region  plasma membrane  plasma membrane  plasma membrane  homophilic cell adhesion via plasma membrane adhesion molecules  neuron cell-cell adhesion  nervous system development  axonogenesis  axon guidance  axon guidance  axonal fasciculation  brain development  axon  axon  neuron projection development  anchored component of membrane  negative regulation of neuron differentiation  regulation of synaptic plasticity  dendrite self-avoidance  cell-cell adhesion mediator activity  
Ontology : EGO-EBIextracellular region  plasma membrane  plasma membrane  plasma membrane  homophilic cell adhesion via plasma membrane adhesion molecules  neuron cell-cell adhesion  nervous system development  axonogenesis  axon guidance  axon guidance  axonal fasciculation  brain development  axon  axon  neuron projection development  anchored component of membrane  negative regulation of neuron differentiation  regulation of synaptic plasticity  dendrite self-avoidance  cell-cell adhesion mediator activity  
NDEx NetworkCNTN4
Atlas of Cancer Signalling NetworkCNTN4
Wikipedia pathwaysCNTN4
Orthology - Evolution
OrthoDB152330
GeneTree (enSembl)ENSG00000144619
Phylogenetic Trees/Animal Genes : TreeFamCNTN4
HOGENOMQ8IWV2
Homologs : HomoloGeneCNTN4
Homology/Alignments : Family Browser (UCSC)CNTN4
Gene fusions - Rearrangements
Fusion : QuiverCNTN4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCNTN4 [hg38]
dbVarCNTN4
ClinVarCNTN4
MonarchCNTN4
1000_GenomesCNTN4 
Exome Variant ServerCNTN4
GNOMAD BrowserENSG00000144619
Varsome BrowserCNTN4
Genomic Variants (DGV)CNTN4 [DGVbeta]
DECIPHERCNTN4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCNTN4 
Mutations
ICGC Data PortalCNTN4 
TCGA Data PortalCNTN4 
Broad Tumor PortalCNTN4
OASIS PortalCNTN4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCNTN4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCNTN4
Mutations and Diseases : HGMDCNTN4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CNTN4
DgiDB (Drug Gene Interaction Database)CNTN4
DoCM (Curated mutations)CNTN4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CNTN4 (select a term)
intoGenCNTN4
Cancer3DCNTN4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607280   
Orphanet1114   
DisGeNETCNTN4
MedgenCNTN4
Genetic Testing Registry CNTN4
NextProtQ8IWV2 [Medical]
GENETestsCNTN4
Target ValidationCNTN4
Huge Navigator CNTN4 [HugePedia]
ClinGenCNTN4 (curated)
Clinical trials, drugs, therapy
MyCancerGenomeCNTN4
Protein Interactions : CTD
Pharm GKB GenePA26688
PharosQ8IWV2
Clinical trialCNTN4
Miscellaneous
canSAR (ICR)CNTN4 (select the gene name)
HarmonizomeCNTN4
DataMed IndexCNTN4
Probes
Litterature
PubMed56 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCNTN4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:10:46 CET 2021
Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.