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COBL (cordon-bleu WH2 repeat protein)

Identity

Alias_namescordon-bleu homolog (mouse)
Alias_symbol (synonym)KIAA0633
Other alias-
HGNC (Hugo) COBL
LocusID (NCBI) 23242
Atlas_Id 54226
Location 7p12.1  [Link to chromosome band 7p12]
Location_base_pair Starts at 51016212 and ends at 51316861 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
COBL (7p12.1) / COBL (7p12.1)COBL (7p12.1) / DUSP14 (17q12)COBL (7p12.1) / FPGS (9q34.11)
COBL (7p12.1) / SEPT14 (7p11.2)COBL 7p12.1 / DUSP14 17q12COBL 7p12.1 / SEPT14 7p11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)COBL   22199
Cards
Entrez_Gene (NCBI)COBL  23242  cordon-bleu WH2 repeat protein
Aliases
GeneCards (Weizmann)COBL
Ensembl hg19 (Hinxton)ENSG00000106078 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000106078 [Gene_View]  chr7:51016212-51316861 [Contig_View]  COBL [Vega]
ICGC DataPortalENSG00000106078
TCGA cBioPortalCOBL
AceView (NCBI)COBL
Genatlas (Paris)COBL
WikiGenes23242
SOURCE (Princeton)COBL
Genetics Home Reference (NIH)COBL
Genomic and cartography
GoldenPath hg38 (UCSC)COBL  -     chr7:51016212-51316861 -  7p12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)COBL  -     7p12.1   [Description]    (hg19-Feb_2009)
EnsemblCOBL - 7p12.1 [CytoView hg19]  COBL - 7p12.1 [CytoView hg38]
Mapping of homologs : NCBICOBL [Mapview hg19]  COBL [Mapview hg38]
OMIM610317   
Gene and transcription
Genbank (Entrez)AB014533 AK293883 AK308718 AK309254 AL713786
RefSeq transcript (Entrez)NM_001287436 NM_001287438 NM_001346441 NM_001346442 NM_001346443 NM_001346444 NM_015198
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)COBL
Cluster EST : UnigeneHs.99141 [ NCBI ]
CGAP (NCI)Hs.99141
Alternative Splicing GalleryENSG00000106078
Gene ExpressionCOBL [ NCBI-GEO ]   COBL [ EBI - ARRAY_EXPRESS ]   COBL [ SEEK ]   COBL [ MEM ]
Gene Expression Viewer (FireBrowse)COBL [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23242
GTEX Portal (Tissue expression)COBL
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75128   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75128  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75128
Splice isoforms : SwissVarO75128
PhosPhoSitePlusO75128
Domaine pattern : Prosite (Expaxy)WH2 (PS51082)   
Domains : Interpro (EBI)Cordon-bleu_ubiquitin_domain    WH2_dom   
Domain families : Pfam (Sanger)Cobl (PF09469)    WH2 (PF02205)   
Domain families : Pfam (NCBI)pfam09469    pfam02205   
Domain families : Smart (EMBL)WH2 (SM00246)  
Conserved Domain (NCBI)COBL
DMDM Disease mutations23242
Blocks (Seattle)COBL
PDB (SRS)4PL8   
PDB (PDBSum)4PL8   
PDB (IMB)4PL8   
PDB (RSDB)4PL8   
Structural Biology KnowledgeBase4PL8   
SCOP (Structural Classification of Proteins)4PL8   
CATH (Classification of proteins structures)4PL8   
SuperfamilyO75128
Human Protein AtlasENSG00000106078
Peptide AtlasO75128
HPRD10843
IPIIPI00384529   IPI00807589   IPI00807621   IPI00807645   IPI00329653   IPI00979308   IPI00927568   IPI00909585   IPI00924789   
Protein Interaction databases
DIP (DOE-UCLA)O75128
IntAct (EBI)O75128
FunCoupENSG00000106078
BioGRIDCOBL
STRING (EMBL)COBL
ZODIACCOBL
Ontologies - Pathways
QuickGOO75128
Ontology : AmiGOembryonic axis specification  ruffle  somite specification  neural tube closure  liver development  actin monomer binding  actin monomer binding  actin filament  plasma membrane  cell cortex  membrane  actin filament polymerization  actin filament polymerization  axon  dendrite  notochord development  floor plate development  neuronal cell body  dendritic growth cone  axonal growth cone  perinuclear region of cytoplasm  digestive tract development  collateral sprouting in absence of injury  actin filament network formation  actin filament network formation  positive regulation of dendrite development  positive regulation of ruffle assembly  
Ontology : EGO-EBIembryonic axis specification  ruffle  somite specification  neural tube closure  liver development  actin monomer binding  actin monomer binding  actin filament  plasma membrane  cell cortex  membrane  actin filament polymerization  actin filament polymerization  axon  dendrite  notochord development  floor plate development  neuronal cell body  dendritic growth cone  axonal growth cone  perinuclear region of cytoplasm  digestive tract development  collateral sprouting in absence of injury  actin filament network formation  actin filament network formation  positive regulation of dendrite development  positive regulation of ruffle assembly  
NDEx NetworkCOBL
Atlas of Cancer Signalling NetworkCOBL
Wikipedia pathwaysCOBL
Orthology - Evolution
OrthoDB23242
GeneTree (enSembl)ENSG00000106078
Phylogenetic Trees/Animal Genes : TreeFamCOBL
HOVERGENO75128
HOGENOMO75128
Homologs : HomoloGeneCOBL
Homology/Alignments : Family Browser (UCSC)COBL
Gene fusions - Rearrangements
Fusion : MitelmanCOBL/DUSP14 [7p12.1/17q12]  
Fusion : MitelmanCOBL/SEPT14 [7p12.1/7p11.2]  [t(7;7)(p11;p12)]  
Fusion: TCGACOBL 7p12.1 DUSP14 17q12 LUAD
Fusion: TCGACOBL 7p12.1 SEPT14 7p11.2 GBM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCOBL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)COBL
dbVarCOBL
ClinVarCOBL
1000_GenomesCOBL 
Exome Variant ServerCOBL
ExAC (Exome Aggregation Consortium)COBL (select the gene name)
Genetic variants : HAPMAP23242
Genomic Variants (DGV)COBL [DGVbeta]
DECIPHERCOBL [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCOBL 
Mutations
ICGC Data PortalCOBL 
TCGA Data PortalCOBL 
Broad Tumor PortalCOBL
OASIS PortalCOBL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCOBL  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCOBL
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch COBL
DgiDB (Drug Gene Interaction Database)COBL
DoCM (Curated mutations)COBL (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)COBL (select a term)
intoGenCOBL
Cancer3DCOBL(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610317   
Orphanet
MedgenCOBL
Genetic Testing Registry COBL
NextProtO75128 [Medical]
TSGene23242
GENETestsCOBL
Target ValidationCOBL
Huge Navigator COBL [HugePedia]
snp3D : Map Gene to Disease23242
BioCentury BCIQCOBL
ClinGenCOBL
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23242
Chemical/Pharm GKB GenePA134869580
Clinical trialCOBL
Miscellaneous
canSAR (ICR)COBL (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCOBL
EVEXCOBL
GoPubMedCOBL
iHOPCOBL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:50:18 CEST 2017

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