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COG5 (component of oligomeric golgi complex 5)

Identity

Alias_namesGOLTC1
golgi transport complex 1 (90 kDa subunit)
Alias_symbol (synonym)GTC90
Other aliasCDG2I
HGNC (Hugo) COG5
LocusID (NCBI) 10466
Atlas_Id 52982
Location 7q22.3  [Link to chromosome band 7q22]
Location_base_pair Starts at 106848298 and ends at 107204959 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
BICD1 (12p11.21) / COG5 (7q22.3)COG5 (7q22.3) / CBLL1 (7q22.3)COG5 (7q22.3) / DNAH7 (2q32.3)
COG5 (7q22.3) / DPP6 (7q36.2)COG5 (7q22.3) / FOXP2 (7q31.1)COG5 (7q22.3) / TBC1D30 (12q14.3)
HMGA2 (12q14.3) / COG5 (7q22.3)RPSAP52 (12q14.3) / COG5 (7q22.3)TFDP2 (3q23) / COG5 (7q22.3)
COG5 7q22.3 / CBLL1 7q22.3COG5 7q22.3 / DNAH7 2q32.3COG5 7q22.3 / DPP6 7q36.2
COG5 7q22.3 / FOXP2 7q31.1COG5 7q22.3 / TBC1D30 12q14.3TFDP2 3q23 / COG5 7q22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Uterus: Leiomyoma


External links

Nomenclature
HGNC (Hugo)COG5   14857
Cards
Entrez_Gene (NCBI)COG5  10466  component of oligomeric golgi complex 5
AliasesCDG2I; GOLTC1; GTC90
GeneCards (Weizmann)COG5
Ensembl hg19 (Hinxton)ENSG00000164597 [Gene_View]  chr7:106848298-107204959 [Contig_View]  COG5 [Vega]
Ensembl hg38 (Hinxton)ENSG00000164597 [Gene_View]  chr7:106848298-107204959 [Contig_View]  COG5 [Vega]
ICGC DataPortalENSG00000164597
TCGA cBioPortalCOG5
AceView (NCBI)COG5
Genatlas (Paris)COG5
WikiGenes10466
SOURCE (Princeton)COG5
Genetics Home Reference (NIH)COG5
Genomic and cartography
GoldenPath hg19 (UCSC)COG5  -     chr7:106848298-107204959 -  7q22.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)COG5  -     7q22.3   [Description]    (hg38-Dec_2013)
EnsemblCOG5 - 7q22.3 [CytoView hg19]  COG5 - 7q22.3 [CytoView hg38]
Mapping of homologs : NCBICOG5 [Mapview hg19]  COG5 [Mapview hg38]
OMIM606821   613612   
Gene and transcription
Genbank (Entrez)AF058718 AK022835 AK123726 AK126275 AK314270
RefSeq transcript (Entrez)NM_001161520 NM_006348 NM_181733
RefSeq genomic (Entrez)NC_000007 NC_018918 NG_028095 NT_007933 NW_004929332
Consensus coding sequences : CCDS (NCBI)COG5
Cluster EST : UnigeneHs.239631 [ NCBI ]
CGAP (NCI)Hs.239631
Alternative Splicing GalleryENSG00000164597
Gene ExpressionCOG5 [ NCBI-GEO ]   COG5 [ EBI - ARRAY_EXPRESS ]   COG5 [ SEEK ]   COG5 [ MEM ]
Gene Expression Viewer (FireBrowse)COG5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10466
GTEX Portal (Tissue expression)COG5
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UP83   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UP83  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UP83
Splice isoforms : SwissVarQ9UP83
PhosPhoSitePlusQ9UP83
Domains : Interpro (EBI)Cog5   
Domain families : Pfam (Sanger)COG5 (PF10392)   
Domain families : Pfam (NCBI)pfam10392   
Conserved Domain (NCBI)COG5
DMDM Disease mutations10466
Blocks (Seattle)COG5
SuperfamilyQ9UP83
Human Protein AtlasENSG00000164597
Peptide AtlasQ9UP83
HPRD08436
IPIIPI00007347   IPI00377050   IPI00885051   
Protein Interaction databases
DIP (DOE-UCLA)Q9UP83
IntAct (EBI)Q9UP83
FunCoupENSG00000164597
BioGRIDCOG5
STRING (EMBL)COG5
ZODIACCOG5
Ontologies - Pathways
QuickGOQ9UP83
Ontology : AmiGOGolgi membrane  molecular_function  protein binding  nucleoplasm  Golgi apparatus  cytosol  ER to Golgi vesicle-mediated transport  intra-Golgi vesicle-mediated transport  intra-Golgi vesicle-mediated transport  protein transport  membrane  Golgi transport complex  Golgi transport complex  trans-Golgi network membrane  
Ontology : EGO-EBIGolgi membrane  molecular_function  protein binding  nucleoplasm  Golgi apparatus  cytosol  ER to Golgi vesicle-mediated transport  intra-Golgi vesicle-mediated transport  intra-Golgi vesicle-mediated transport  protein transport  membrane  Golgi transport complex  Golgi transport complex  trans-Golgi network membrane  
NDEx NetworkCOG5
Atlas of Cancer Signalling NetworkCOG5
Wikipedia pathwaysCOG5
Orthology - Evolution
OrthoDB10466
GeneTree (enSembl)ENSG00000164597
Phylogenetic Trees/Animal Genes : TreeFamCOG5
HOVERGENQ9UP83
HOGENOMQ9UP83
Homologs : HomoloGeneCOG5
Homology/Alignments : Family Browser (UCSC)COG5
Gene fusions - Rearrangements
Fusion : MitelmanCOG5/CBLL1 [7q22.3/7q22.3]  
Fusion : MitelmanCOG5/DNAH7 [7q22.3/2q32.3]  [t(2;7)(q32;q31)]  
Fusion : MitelmanCOG5/DPP6 [7q22.3/7q36.2]  [t(7;7)(q31;q36)]  
Fusion : MitelmanCOG5/FOXP2 [7q22.3/7q31.1]  [t(7;7)(q31;q31)]  
Fusion : MitelmanCOG5/TBC1D30 [7q22.3/12q14.3]  [t(7;12)(q31;q14)]  
Fusion : MitelmanHMGA2/COG5 [12q14.3/7q22.3]  [t(7;12)(q31;q14)]  
Fusion: TCGACOG5 7q22.3 CBLL1 7q22.3 LUAD
Fusion: TCGACOG5 7q22.3 DNAH7 2q32.3 BRCA
Fusion: TCGACOG5 7q22.3 DPP6 7q36.2 BRCA
Fusion: TCGACOG5 7q22.3 FOXP2 7q31.1 BRCA
Fusion: TCGACOG5 7q22.3 TBC1D30 12q14.3 PRAD
Fusion: TCGATFDP2 3q23 COG5 7q22.3 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCOG5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)COG5
dbVarCOG5
ClinVarCOG5
1000_GenomesCOG5 
Exome Variant ServerCOG5
ExAC (Exome Aggregation Consortium)COG5 (select the gene name)
Genetic variants : HAPMAP10466
Genomic Variants (DGV)COG5 [DGVbeta]
DECIPHER (Syndromes)7:106848298-107204959  ENSG00000164597
CONAN: Copy Number AnalysisCOG5 
Mutations
ICGC Data PortalCOG5 
TCGA Data PortalCOG5 
Broad Tumor PortalCOG5
OASIS PortalCOG5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCOG5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCOG5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
BioMutasearch COG5
DgiDB (Drug Gene Interaction Database)COG5
DoCM (Curated mutations)COG5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)COG5 (select a term)
intoGenCOG5
Cancer3DCOG5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606821    613612   
Orphanet20062   
MedgenCOG5
Genetic Testing Registry COG5
NextProtQ9UP83 [Medical]
TSGene10466
GENETestsCOG5
Huge Navigator COG5 [HugePedia]
snp3D : Map Gene to Disease10466
BioCentury BCIQCOG5
ClinGenCOG5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10466
Chemical/Pharm GKB GenePA26698
Clinical trialCOG5
Miscellaneous
canSAR (ICR)COG5 (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCOG5
EVEXCOG5
GoPubMedCOG5
iHOPCOG5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 14:57:09 CEST 2017

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