COL18A1 (collagen type XVIII alpha 1 chain)

2003-02-01  

Identity

HGNC
LOCATION
21q22.3
LOCUSID
ALIAS
GLCC,KNO,KNO1,KS
FUSION GENES

Other Information

Locus ID:

NCBI: 80781
MIM: 120328
HGNC: 2195
Ensembl: ENSG00000182871

Variants:

dbSNP: 80781
ClinVar: 80781
TCGA: ENSG00000182871
COSMIC: COL18A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182871ENST00000342220H7BXV5
ENSG00000182871ENST00000355480P39060
ENSG00000182871ENST00000359759P39060
ENSG00000182871ENST00000423214H7C457
ENSG00000182871ENST00000651438P39060

Expression (GTEx)

0
100
200
300
400
500
600
700

Pathways

PathwaySourceExternal ID
Protein digestion and absorptionKEGGko04974
Protein digestion and absorptionKEGGhsa04974
Extracellular matrix organizationREACTOMER-HSA-1474244
Collagen formationREACTOMER-HSA-1474290
Collagen biosynthesis and modifying enzymesREACTOMER-HSA-1650814
Assembly of collagen fibrils and other multimeric structuresREACTOMER-HSA-2022090
Laminin interactionsREACTOMER-HSA-3000157
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Activation of Matrix MetalloproteinasesREACTOMER-HSA-1592389
Collagen degradationREACTOMER-HSA-1442490
Integrin cell surface interactionsREACTOMER-HSA-216083
Collagen chain trimerizationREACTOMER-HSA-8948216

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
126822932003Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins.124
118156232002Endostatin causes G1 arrest of endothelial cells through inhibition of cyclin D1.51
159506182005Generation of biologically active endostatin fragments from human collagen XVIII by distinct matrix metalloproteases.46
183818142008Voltage-dependent anion channel 1 is involved in endostatin-induced endothelial cell apoptosis.43
192985262009Endostatin induces autophagy in endothelial cells by modulating Beclin 1 and beta-catenin levels.40
190746762009Endostatin and angiostatin are increased in diabetic patients with coronary artery disease and associated with impaired coronary collateral formation.34
186766802008Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.32
176530452007Candidate gene and locus analysis of myopia.30
200639892010The effect of P2Y-mediated platelet activation on the release of VEGF and endostatin from platelets.29
117816962001High serum endostatin levels in Down syndrome: implications for improved treatment and prevention of solid tumours.28

Citation

Dessen P

COL18A1 (collagen type XVIII alpha 1 chain)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40123/col18a1