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COMMD1 (copper metabolism domain containing 1)

Identity

Alias_namesC2orf5
chromosome 2 open reading frame 5 (MURR1)
copper metabolism (Murr1) domain containing 1
Alias_symbol (synonym)MURR1
MGC27155
Other alias
HGNC (Hugo) COMMD1
LocusID (NCBI) 150684
Atlas_Id 50492
Location 2p15  [Link to chromosome band 2p15]
Location_base_pair Starts at 61888723 and ends at 62136070 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
COMMD1 (2p15) / COMMD1 (2p15)DIRAS2 (9q22.2) / COMMD1 (2p15)EHBP1 (2p15) / COMMD1 (2p15)
MDH1 (2p15) / COMMD1 (2p15)SMG1 (16p12.3) / COMMD1 (2p15)EHBP1 2p15 / COMMD1 2p15
MDH1 2p15 / COMMD1 2p15

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)COMMD1   23024
Cards
Entrez_Gene (NCBI)COMMD1  150684  copper metabolism domain containing 1
AliasesC2orf5; MURR1
GeneCards (Weizmann)COMMD1
Ensembl hg19 (Hinxton)ENSG00000173163 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000173163 [Gene_View]  chr2:61888723-62136070 [Contig_View]  COMMD1 [Vega]
ICGC DataPortalENSG00000173163
TCGA cBioPortalCOMMD1
AceView (NCBI)COMMD1
Genatlas (Paris)COMMD1
WikiGenes150684
SOURCE (Princeton)COMMD1
Genetics Home Reference (NIH)COMMD1
Genomic and cartography
GoldenPath hg38 (UCSC)COMMD1  -     chr2:61888723-62136070 +  2p15   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)COMMD1  -     2p15   [Description]    (hg19-Feb_2009)
EnsemblCOMMD1 - 2p15 [CytoView hg19]  COMMD1 - 2p15 [CytoView hg38]
Mapping of homologs : NCBICOMMD1 [Mapview hg19]  COMMD1 [Mapview hg38]
OMIM607238   
Gene and transcription
Genbank (Entrez)AB178811 AK223607 AK294203 BC009266 BC022046
RefSeq transcript (Entrez)NM_001321781 NM_001321782 NM_152516
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)COMMD1
Cluster EST : UnigeneHs.468702 [ NCBI ]
CGAP (NCI)Hs.468702
Alternative Splicing GalleryENSG00000173163
Gene ExpressionCOMMD1 [ NCBI-GEO ]   COMMD1 [ EBI - ARRAY_EXPRESS ]   COMMD1 [ SEEK ]   COMMD1 [ MEM ]
Gene Expression Viewer (FireBrowse)COMMD1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)150684
GTEX Portal (Tissue expression)COMMD1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N668   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N668  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N668
Splice isoforms : SwissVarQ8N668
PhosPhoSitePlusQ8N668
Domaine pattern : Prosite (Expaxy)COMM (PS51269)   
Domains : Interpro (EBI)COMM    COMMD1_N   
Domain families : Pfam (Sanger)COMM_domain (PF07258)    COMMD1_N (PF17221)   
Domain families : Pfam (NCBI)pfam07258    pfam17221   
Conserved Domain (NCBI)COMMD1
DMDM Disease mutations150684
Blocks (Seattle)COMMD1
PDB (SRS)2H2M   
PDB (PDBSum)2H2M   
PDB (IMB)2H2M   
PDB (RSDB)2H2M   
Structural Biology KnowledgeBase2H2M   
SCOP (Structural Classification of Proteins)2H2M   
CATH (Classification of proteins structures)2H2M   
SuperfamilyQ8N668
Human Protein AtlasENSG00000173163
Peptide AtlasQ8N668
HPRD06253
IPIIPI00171117   IPI00918005   IPI00917011   IPI00915783   IPI00916050   
Protein Interaction databases
DIP (DOE-UCLA)Q8N668
IntAct (EBI)Q8N668
FunCoupENSG00000173163
BioGRIDCOMMD1
STRING (EMBL)COMMD1
ZODIACCOMMD1
Ontologies - Pathways
QuickGOQ8N668
Ontology : AmiGOcopper ion binding  protein binding  phosphatidylinositol-4,5-bisphosphate binding  phosphatidylinositol-3,4,5-trisphosphate binding  nucleus  nucleoplasm  cytoplasm  early endosome  cytosol  transcription, DNA-templated  Golgi to plasma membrane transport  endosome membrane  protein transport  positive regulation of protein ubiquitination  Cul2-RING ubiquitin ligase complex  negative regulation of NF-kappaB transcription factor activity  negative regulation of NF-kappaB transcription factor activity  regulation of proteasomal ubiquitin-dependent protein catabolic process  identical protein binding  protein homodimerization activity  phosphatidylinositol-3,4-bisphosphate binding  plasma membrane to endosome transport  recycling endosome  copper ion homeostasis  extracellular exosome  phosphatidic acid binding  phosphatidylinositol-3,5-bisphosphate binding  negative regulation of sodium ion transmembrane transport  negative regulation of sodium ion transmembrane transport  negative regulation of protein localization to cell surface  
Ontology : EGO-EBIcopper ion binding  protein binding  phosphatidylinositol-4,5-bisphosphate binding  phosphatidylinositol-3,4,5-trisphosphate binding  nucleus  nucleoplasm  cytoplasm  early endosome  cytosol  transcription, DNA-templated  Golgi to plasma membrane transport  endosome membrane  protein transport  positive regulation of protein ubiquitination  Cul2-RING ubiquitin ligase complex  negative regulation of NF-kappaB transcription factor activity  negative regulation of NF-kappaB transcription factor activity  regulation of proteasomal ubiquitin-dependent protein catabolic process  identical protein binding  protein homodimerization activity  phosphatidylinositol-3,4-bisphosphate binding  plasma membrane to endosome transport  recycling endosome  copper ion homeostasis  extracellular exosome  phosphatidic acid binding  phosphatidylinositol-3,5-bisphosphate binding  negative regulation of sodium ion transmembrane transport  negative regulation of sodium ion transmembrane transport  negative regulation of protein localization to cell surface  
NDEx NetworkCOMMD1
Atlas of Cancer Signalling NetworkCOMMD1
Wikipedia pathwaysCOMMD1
Orthology - Evolution
OrthoDB150684
GeneTree (enSembl)ENSG00000173163
Phylogenetic Trees/Animal Genes : TreeFamCOMMD1
HOVERGENQ8N668
HOGENOMQ8N668
Homologs : HomoloGeneCOMMD1
Homology/Alignments : Family Browser (UCSC)COMMD1
Gene fusions - Rearrangements
Fusion: TCGAEHBP1 2p15 COMMD1 2p15 BRCA LUAD
Fusion: TCGAMDH1 2p15 COMMD1 2p15 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCOMMD1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)COMMD1
dbVarCOMMD1
ClinVarCOMMD1
1000_GenomesCOMMD1 
Exome Variant ServerCOMMD1
ExAC (Exome Aggregation Consortium)COMMD1 (select the gene name)
Genetic variants : HAPMAP150684
Genomic Variants (DGV)COMMD1 [DGVbeta]
DECIPHERCOMMD1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCOMMD1 
Mutations
ICGC Data PortalCOMMD1 
TCGA Data PortalCOMMD1 
Broad Tumor PortalCOMMD1
OASIS PortalCOMMD1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCOMMD1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCOMMD1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch COMMD1
DgiDB (Drug Gene Interaction Database)COMMD1
DoCM (Curated mutations)COMMD1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)COMMD1 (select a term)
intoGenCOMMD1
Cancer3DCOMMD1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607238   
Orphanet
MedgenCOMMD1
Genetic Testing Registry COMMD1
NextProtQ8N668 [Medical]
TSGene150684
GENETestsCOMMD1
Target ValidationCOMMD1
Huge Navigator COMMD1 [HugePedia]
snp3D : Map Gene to Disease150684
BioCentury BCIQCOMMD1
ClinGenCOMMD1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD150684
Chemical/Pharm GKB GenePA134891368
Clinical trialCOMMD1
Miscellaneous
canSAR (ICR)COMMD1 (select the gene name)
Probes
Litterature
PubMed73 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCOMMD1
EVEXCOMMD1
GoPubMedCOMMD1
iHOPCOMMD1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Wed Jun 7 12:29:11 CEST 2017

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