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COMMD1 (copper metabolism domain containing 1)

Identity

Alias (NCBI)C2orf5
MURR1
HGNC (Hugo) COMMD1
HGNC Alias symbMURR1
MGC27155
HGNC Alias namecopper metabolism gene MURR1
 COMM domain containing 1
HGNC Previous nameC2orf5
HGNC Previous namechromosome 2 open reading frame 5 (MURR1)
 copper metabolism (Murr1) domain containing 1
LocusID (NCBI) 150684
Atlas_Id 50492
Location 2p15  [Link to chromosome band 2p15]
Location_base_pair Starts at 61905642 and ends at 62136070 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
COMMD1 (2p15) / COMMD1 (2p15)DIRAS2 (9q22.2) / COMMD1 (2p15)EHBP1 (2p15) / COMMD1 (2p15)
MDH1 (2p15) / COMMD1 (2p15)SMG1 (16p12.3) / COMMD1 (2p15)EHBP1 2p15 / COMMD1 2p15
MDH1 2p15 / COMMD1 2p15

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)COMMD1   23024
Cards
Entrez_Gene (NCBI)COMMD1    copper metabolism domain containing 1
AliasesC2orf5; MURR1
GeneCards (Weizmann)COMMD1
Ensembl hg19 (Hinxton)ENSG00000173163 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000173163 [Gene_View]  ENSG00000173163 [Sequence]  chr2:61905642-62136070 [Contig_View]  COMMD1 [Vega]
ICGC DataPortalENSG00000173163
TCGA cBioPortalCOMMD1
AceView (NCBI)COMMD1
Genatlas (Paris)COMMD1
SOURCE (Princeton)COMMD1
Genetics Home Reference (NIH)COMMD1
Genomic and cartography
GoldenPath hg38 (UCSC)COMMD1  -     chr2:61905642-62136070 +  2p15   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)COMMD1  -     2p15   [Description]    (hg19-Feb_2009)
GoldenPathCOMMD1 - 2p15 [CytoView hg19]  COMMD1 - 2p15 [CytoView hg38]
ImmunoBaseENSG00000173163
Genome Data Viewer NCBICOMMD1 [Mapview hg19]  
OMIM607238   
Gene and transcription
Genbank (Entrez)AB178811 AK223607 AK294203 BC009266 BC022046
RefSeq transcript (Entrez)NM_001321781 NM_001321782 NM_001371765 NM_152516
Consensus coding sequences : CCDS (NCBI)COMMD1
Gene ExpressionCOMMD1 [ NCBI-GEO ]   COMMD1 [ EBI - ARRAY_EXPRESS ]   COMMD1 [ SEEK ]   COMMD1 [ MEM ]
Gene Expression Viewer (FireBrowse)COMMD1 [ Firebrowse - Broad ]
GenevisibleExpression of COMMD1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)150684
GTEX Portal (Tissue expression)COMMD1
Human Protein AtlasENSG00000173163-COMMD1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N668   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N668  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N668
PhosPhoSitePlusQ8N668
Domaine pattern : Prosite (Expaxy)COMM (PS51269)   
Domains : Interpro (EBI)COMM    COMMD1_N    Murr1   
Domain families : Pfam (Sanger)COMM_domain (PF07258)    COMMD1_N (PF17221)   
Domain families : Pfam (NCBI)pfam07258    pfam17221   
Conserved Domain (NCBI)COMMD1
PDB (RSDB)2H2M   
PDB Europe2H2M   
PDB (PDBSum)2H2M   
PDB (IMB)2H2M   
Structural Biology KnowledgeBase2H2M   
SCOP (Structural Classification of Proteins)2H2M   
CATH (Classification of proteins structures)2H2M   
SuperfamilyQ8N668
AlphaFold pdb e-kbQ8N668   
Human Protein Atlas [tissue]ENSG00000173163-COMMD1 [tissue]
HPRD06253
Protein Interaction databases
DIP (DOE-UCLA)Q8N668
IntAct (EBI)Q8N668
BioGRIDCOMMD1
STRING (EMBL)COMMD1
ZODIACCOMMD1
Ontologies - Pathways
QuickGOQ8N668
Ontology : AmiGOcopper ion binding  protein binding  phosphatidylinositol-4,5-bisphosphate binding  phosphatidylinositol-3,4,5-trisphosphate binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  endosome  early endosome  cytosol  cytosol  nucleotide-excision repair  Golgi to plasma membrane transport  endosome membrane  protein transport  protein ubiquitination  sodium channel inhibitor activity  positive regulation of protein ubiquitination  positive regulation of protein ubiquitination  Cul2-RING ubiquitin ligase complex  negative regulation of NF-kappaB transcription factor activity  negative regulation of NF-kappaB transcription factor activity  negative regulation of NF-kappaB transcription factor activity  regulation of proteasomal ubiquitin-dependent protein catabolic process  regulation of proteasomal ubiquitin-dependent protein catabolic process  identical protein binding  protein homodimerization activity  phosphatidylinositol-3,4-bisphosphate binding  post-translational protein modification  plasma membrane to endosome transport  recycling endosome  copper ion homeostasis  copper ion homeostasis  phosphatidic acid binding  phosphatidylinositol-3,5-bisphosphate binding  negative regulation of sodium ion transmembrane transport  negative regulation of sodium ion transmembrane transport  negative regulation of sodium ion transmembrane transport  negative regulation of protein localization to cell surface  negative regulation of protein localization to cell surface  
Ontology : EGO-EBIcopper ion binding  protein binding  phosphatidylinositol-4,5-bisphosphate binding  phosphatidylinositol-3,4,5-trisphosphate binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  endosome  early endosome  cytosol  cytosol  nucleotide-excision repair  Golgi to plasma membrane transport  endosome membrane  protein transport  protein ubiquitination  sodium channel inhibitor activity  positive regulation of protein ubiquitination  positive regulation of protein ubiquitination  Cul2-RING ubiquitin ligase complex  negative regulation of NF-kappaB transcription factor activity  negative regulation of NF-kappaB transcription factor activity  negative regulation of NF-kappaB transcription factor activity  regulation of proteasomal ubiquitin-dependent protein catabolic process  regulation of proteasomal ubiquitin-dependent protein catabolic process  identical protein binding  protein homodimerization activity  phosphatidylinositol-3,4-bisphosphate binding  post-translational protein modification  plasma membrane to endosome transport  recycling endosome  copper ion homeostasis  copper ion homeostasis  phosphatidic acid binding  phosphatidylinositol-3,5-bisphosphate binding  negative regulation of sodium ion transmembrane transport  negative regulation of sodium ion transmembrane transport  negative regulation of sodium ion transmembrane transport  negative regulation of protein localization to cell surface  negative regulation of protein localization to cell surface  
NDEx NetworkCOMMD1
Atlas of Cancer Signalling NetworkCOMMD1
Wikipedia pathwaysCOMMD1
Orthology - Evolution
OrthoDB150684
GeneTree (enSembl)ENSG00000173163
Phylogenetic Trees/Animal Genes : TreeFamCOMMD1
Homologs : HomoloGeneCOMMD1
Homology/Alignments : Family Browser (UCSC)COMMD1
Gene fusions - Rearrangements
Fusion : QuiverCOMMD1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCOMMD1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)COMMD1
dbVarCOMMD1
ClinVarCOMMD1
MonarchCOMMD1
1000_GenomesCOMMD1 
Exome Variant ServerCOMMD1
GNOMAD BrowserENSG00000173163
Varsome BrowserCOMMD1
ACMGCOMMD1 variants
VarityQ8N668
Genomic Variants (DGV)COMMD1 [DGVbeta]
DECIPHERCOMMD1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCOMMD1 
Mutations
ICGC Data PortalCOMMD1 
TCGA Data PortalCOMMD1 
Broad Tumor PortalCOMMD1
OASIS PortalCOMMD1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCOMMD1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCOMMD1
Mutations and Diseases : HGMDCOMMD1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCOMMD1
DgiDB (Drug Gene Interaction Database)COMMD1
DoCM (Curated mutations)COMMD1
CIViC (Clinical Interpretations of Variants in Cancer)COMMD1
Cancer3DCOMMD1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607238   
Orphanet
DisGeNETCOMMD1
MedgenCOMMD1
Genetic Testing Registry COMMD1
NextProtQ8N668 [Medical]
GENETestsCOMMD1
Target ValidationCOMMD1
Huge Navigator COMMD1 [HugePedia]
ClinGenCOMMD1
Clinical trials, drugs, therapy
MyCancerGenomeCOMMD1
Protein Interactions : CTDCOMMD1
Pharm GKB GenePA134891368
PharosQ8N668
Clinical trialCOMMD1
Miscellaneous
canSAR (ICR)COMMD1
HarmonizomeCOMMD1
DataMed IndexCOMMD1
Probes
Litterature
PubMed95 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCOMMD1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:04:48 CEST 2021

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