COMT (catechol-O-methyltransferase)

Identity

Other names	-
HGNC	COMT
Location	22q11.21
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	COMT   2228
Entrez_Gene	COMT  1312  catechol-O-methyltransferase
	Cards
GeneCards	COMT
Ensembl	COMT [Search_View]   ENSG00000093010 [Gene_View]
Genatlas	COMT
GeneLynx	COMT
eGenome	COMT
euGene	1312
	Genomic and cartography
GoldenPath	COMT  -  22q11.21   chr22:18309309-18336530 +  22q11.21   [Description]    (hg18-March_2006)
Ensembl	COMT - 22q11.21 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	COMT
	Gene and transcription
Genbank	AK130031 [ ENTREZ ]
Genbank	AK290440 [ ENTREZ ]
Genbank	BC000419 [ ENTREZ ]
Genbank	BC005867 [ ENTREZ ]
Genbank	BC011935 [ ENTREZ ]
RefSeq	NM_000754 [ SRS ]    NM_000754 [ ENTREZ ]
RefSeq	NM_007310 [ SRS ]    NM_007310 [ ENTREZ ]
RefSeq	AC_000065 [ SRS ]    AC_000065 [ ENTREZ ]
RefSeq	AC_000154 [ SRS ]    AC_000154 [ ENTREZ ]
RefSeq	NC_000022 [ SRS ]    NC_000022 [ ENTREZ ]
RefSeq	NT_011519 [ SRS ]    NT_011519 [ ENTREZ ]
RefSeq	NW_001838737 [ SRS ]    NW_001838737 [ ENTREZ ]
RefSeq	NW_927495 [ SRS ]    NW_927495 [ ENTREZ ]
AceView	COMT AceView - NCBI
Unigene	Hs.704514 [ SRS ]    Hs.704514 [ NCBI ]     HS704514 [ spliceNest ]
Fast-db	1437 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P21964 [ SRS]    P21964 [ EXPASY ]     P21964 [ INTERPRO ]     P21964 [ UNIPROT ]
Interpro	IPR017128 Catechol_O-MeTrfase_euk [ SRS ]    IPR017128 Catechol_O-MeTrfase_euk [ EBI ]
Interpro	IPR002935 O-MeTrfase_3 [ SRS ]    IPR002935 O-MeTrfase_3 [ EBI ]
CluSTr	P21964
Pfam	PF01596 Methyltransf_3 [ SRS ]    PF01596 Methyltransf_3 [ Sanger ]    pfam01596 [ NCBI-CDD ]
Blocks	P21964
PDB	3BWM [ SRS ]    3BWM [ PdbSum ],   3BWM [ IMB ]   3BWM [ RSDB ]
PDB	3BWY [ SRS ]    3BWY [ PdbSum ],   3BWY [ IMB ]   3BWY [ RSDB ]
HPRD	00284
	Protein Interaction databases
DIP	P21964
IntAct	P21964
	Polymorphism : SNP, mutations, diseases
OMIM	116790;167870;181500    [ map ]
GENECLINICS	116790;167870;181500
SNP	COMT [dbSNP-NCBI]
SNP	NM_000754 [SNP-NCI]
SNP	NM_007310 [SNP-NCI]
SNP	COMT [GeneSNPs - Utah]  COMT] [HGBASE - SRS]
HAPMAP	COMT [HAPMAP]
HGMD	COMT
	General knowledge
Family Browser	COMT [UCSC Family Browser]
SOURCE	NM_000754
SOURCE	NM_007310
SMD	Hs.704514
SAGE	Hs.704514
GO	magnesium ion binding [Amigo]  magnesium ion binding
GO	protein binding [Amigo]  protein binding
GO	soluble fraction [Amigo]  soluble fraction
GO	cytoplasm [Amigo]  cytoplasm
GO	microsome [Amigo]  microsome
GO	cytosol [Amigo]  cytosol
GO	catecholamine metabolic process [Amigo]  catecholamine metabolic process
GO	O-methyltransferase activity [Amigo]  O-methyltransferase activity
GO	membrane [Amigo]  membrane
GO	integral to membrane [Amigo]  integral to membrane
GO	catechol O-methyltransferase activity [Amigo]  catechol O-methyltransferase activity
GO	catechol O-methyltransferase activity [Amigo]  catechol O-methyltransferase activity
GO	transferase activity [Amigo]  transferase activity
GO	dopamine catabolic process [Amigo]  dopamine catabolic process
KEGG	Tyrosine metabolism
PubGene	COMT
TreeFam	COMT
CTD	1312 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	COMT Related clones (RZPD - Berlin)
	PubMed
PubMed	499 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Sep 29 17:53:37 2008