COP1 (COP1 E3 ubiquitin ligase)

2018-02-01  

Identity

HGNC
COP1
LOCATION
1q25.1
LOCUSID
64326
ALIAS
CFAP78,FAP78,RFWD2,RNF200

Other Information

Locus ID:

NCBI: 64326
MIM: 608067
HGNC: 17440
Ensembl: ENSG00000143207

Variants:

dbSNP: 64326
ClinVar: 64326
TCGA: ENSG00000143207
COSMIC: COP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143207ENST00000308769Q8NHY2
ENSG00000143207ENST00000367666H0Y339
ENSG00000143207ENST00000367667H0Y340
ENSG00000143207ENST00000367669Q8NHY2
ENSG00000143207ENST00000459744H0YF49
ENSG00000143207ENST00000474194Q8NHY2
ENSG00000143207ENST00000491600E9PMW8
ENSG00000143207ENST00000498306E9PJB5
ENSG00000143207ENST00000649803A0A3B3ISQ9

Pathways

PathwaySourceExternal ID
p53 signaling pathwayKEGGko04115
Ubiquitin mediated proteolysisKEGGko04120
p53 signaling pathwayKEGGhsa04115
Ubiquitin mediated proteolysisKEGGhsa04120
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G1/S DNA Damage CheckpointsREACTOMER-HSA-69615
p53-Dependent G1/S DNA damage checkpointREACTOMER-HSA-69580
p53-Dependent G1 DNA Damage ResponseREACTOMER-HSA-69563
Stabilization of p53REACTOMER-HSA-69541
Autodegradation of the E3 ubiquitin ligase COP1REACTOMER-HSA-349425

References

Pubmed IDYearTitleCitations
151033852004The ubiquitin ligase COP1 is a critical negative regulator of p53.228
151033852004The ubiquitin ligase COP1 is a critical negative regulator of p53.228
147394642004Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase.139
215724352011COP1 is a tumour suppressor that causes degradation of ETS transcription factors.64
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
169317612006ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage.50
154922382004COP1, the negative regulator of p53, is overexpressed in breast and ovarian adenocarcinomas.38
198051452009E3 ubiquitin ligase COP1 regulates the stability and functions of MTA1.35
188151342008COP1 functions as a FoxO1 ubiquitin E3 ligase to regulate FoxO1-mediated gene expression.34
209594912010Definition of ubiquitination modulator COP1 as a novel therapeutic target in human hepatocellular carcinoma.28

Citation

Dessen P

COP1 (COP1 E3 ubiquitin ligase)

Atlas Genet Cytogenet Oncol Haematol. 2018-02-01

Online version: http://atlasgeneticsoncology.org/gene/57360/cop1