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COPS3 (COP9 signalosome subunit 3)

Identity

Alias_namesCOP9 (constitutive photomorphogenic, Arabidopsis, homolog) subunit 3
COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)
Alias_symbol (synonym)SGN3
CSN3
Other alias
HGNC (Hugo) COPS3
LocusID (NCBI) 8533
Atlas_Id 46656
Location 17p11.2  [Link to chromosome band 17p11]
Location_base_pair Starts at 17246624 and ends at 17280698 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
COPS3 (17p11.2) / TEKT3 (17p12)HSD17B4 (5q23.1) / COPS3 (17p11.2)COPS3 17p11.2 / TEKT3 17p12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)COPS3   2239
Cards
Entrez_Gene (NCBI)COPS3  8533  COP9 signalosome subunit 3
AliasesCSN3; SGN3
GeneCards (Weizmann)COPS3
Ensembl hg19 (Hinxton)ENSG00000141030 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000141030 [Gene_View]  chr17:17246624-17280698 [Contig_View]  COPS3 [Vega]
ICGC DataPortalENSG00000141030
TCGA cBioPortalCOPS3
AceView (NCBI)COPS3
Genatlas (Paris)COPS3
WikiGenes8533
SOURCE (Princeton)COPS3
Genetics Home Reference (NIH)COPS3
Genomic and cartography
GoldenPath hg38 (UCSC)COPS3  -     chr17:17246624-17280698 -  17p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)COPS3  -     17p11.2   [Description]    (hg19-Feb_2009)
EnsemblCOPS3 - 17p11.2 [CytoView hg19]  COPS3 - 17p11.2 [CytoView hg38]
Mapping of homologs : NCBICOPS3 [Mapview hg19]  COPS3 [Mapview hg38]
OMIM604665   
Gene and transcription
Genbank (Entrez)AF031647 AF098109 AK297706 AK302304 AK312476
RefSeq transcript (Entrez)NM_001199125 NM_001316354 NM_001316355 NM_001316356 NM_001316357 NM_001316358 NM_003653
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)COPS3
Cluster EST : UnigeneHs.6076 [ NCBI ]
CGAP (NCI)Hs.6076
Alternative Splicing GalleryENSG00000141030
Gene ExpressionCOPS3 [ NCBI-GEO ]   COPS3 [ EBI - ARRAY_EXPRESS ]   COPS3 [ SEEK ]   COPS3 [ MEM ]
Gene Expression Viewer (FireBrowse)COPS3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8533
GTEX Portal (Tissue expression)COPS3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UNS2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UNS2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UNS2
Splice isoforms : SwissVarQ9UNS2
PhosPhoSitePlusQ9UNS2
Domains : Interpro (EBI)PCI_dom    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)PCI (PF01399)   
Domain families : Pfam (NCBI)pfam01399   
Domain families : Smart (EMBL)PINT (SM00088)  
Conserved Domain (NCBI)COPS3
DMDM Disease mutations8533
Blocks (Seattle)COPS3
PDB (SRS)4D10    4D18    4WSN   
PDB (PDBSum)4D10    4D18    4WSN   
PDB (IMB)4D10    4D18    4WSN   
PDB (RSDB)4D10    4D18    4WSN   
Structural Biology KnowledgeBase4D10    4D18    4WSN   
SCOP (Structural Classification of Proteins)4D10    4D18    4WSN   
CATH (Classification of proteins structures)4D10    4D18    4WSN   
SuperfamilyQ9UNS2
Human Protein AtlasENSG00000141030
Peptide AtlasQ9UNS2
HPRD07262
IPIIPI00025721   IPI00980899   IPI00797314   IPI00797970   
Protein Interaction databases
DIP (DOE-UCLA)Q9UNS2
IntAct (EBI)Q9UNS2
FunCoupENSG00000141030
BioGRIDCOPS3
STRING (EMBL)COPS3
ZODIACCOPS3
Ontologies - Pathways
QuickGOQ9UNS2
Ontology : AmiGOprotein deneddylation  nucleotide-excision repair, DNA damage recognition  in utero embryonic development  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  cytosol  transcription-coupled nucleotide-excision repair  ubiquitin-dependent protein catabolic process  signal transduction  COP9 signalosome  response to light stimulus  
Ontology : EGO-EBIprotein deneddylation  nucleotide-excision repair, DNA damage recognition  in utero embryonic development  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  cytosol  transcription-coupled nucleotide-excision repair  ubiquitin-dependent protein catabolic process  signal transduction  COP9 signalosome  response to light stimulus  
NDEx NetworkCOPS3
Atlas of Cancer Signalling NetworkCOPS3
Wikipedia pathwaysCOPS3
Orthology - Evolution
OrthoDB8533
GeneTree (enSembl)ENSG00000141030
Phylogenetic Trees/Animal Genes : TreeFamCOPS3
HOVERGENQ9UNS2
HOGENOMQ9UNS2
Homologs : HomoloGeneCOPS3
Homology/Alignments : Family Browser (UCSC)COPS3
Gene fusions - Rearrangements
Fusion : MitelmanCOPS3/TEKT3 [17p11.2/17p12]  
Fusion: TCGACOPS3 17p11.2 TEKT3 17p12 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCOPS3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)COPS3
dbVarCOPS3
ClinVarCOPS3
1000_GenomesCOPS3 
Exome Variant ServerCOPS3
ExAC (Exome Aggregation Consortium)COPS3 (select the gene name)
Genetic variants : HAPMAP8533
Genomic Variants (DGV)COPS3 [DGVbeta]
DECIPHERCOPS3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCOPS3 
Mutations
ICGC Data PortalCOPS3 
TCGA Data PortalCOPS3 
Broad Tumor PortalCOPS3
OASIS PortalCOPS3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCOPS3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCOPS3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch COPS3
DgiDB (Drug Gene Interaction Database)COPS3
DoCM (Curated mutations)COPS3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)COPS3 (select a term)
intoGenCOPS3
Cancer3DCOPS3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604665   
Orphanet
MedgenCOPS3
Genetic Testing Registry COPS3
NextProtQ9UNS2 [Medical]
TSGene8533
GENETestsCOPS3
Huge Navigator COPS3 [HugePedia]
snp3D : Map Gene to Disease8533
BioCentury BCIQCOPS3
ClinGenCOPS3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8533
Chemical/Pharm GKB GenePA26755
Clinical trialCOPS3
Miscellaneous
canSAR (ICR)COPS3 (select the gene name)
Probes
Litterature
PubMed88 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCOPS3
EVEXCOPS3
GoPubMedCOPS3
iHOPCOPS3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:11:25 CEST 2017

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