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COPS3 (COP9 signalosome subunit 3)

Identity

Alias (NCBI)CSN3
SGN3
HGNC (Hugo) COPS3
HGNC Alias symbSGN3
CSN3
HGNC Previous nameCOP9 (constitutive photomorphogenic, Arabidopsis, homolog) subunit 3
 COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)
LocusID (NCBI) 8533
Atlas_Id 46656
Location 17p11.2  [Link to chromosome band 17p11]
Location_base_pair Starts at 17246616 and ends at 17281246 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
COPS3 (17p11.2)::TEKT3 (17p12)HSD17B4 (5q23.1)::COPS3 (17p11.2)COPS3 17p11.2::TEKT3 17p12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)COPS3   2239
Cards
Entrez_Gene (NCBI)COPS3    COP9 signalosome subunit 3
AliasesCSN3; SGN3
GeneCards (Weizmann)COPS3
Ensembl hg19 (Hinxton)ENSG00000141030 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000141030 [Gene_View]  ENSG00000141030 [Sequence]  chr17:17246616-17281246 [Contig_View]  COPS3 [Vega]
ICGC DataPortalENSG00000141030
TCGA cBioPortalCOPS3
AceView (NCBI)COPS3
Genatlas (Paris)COPS3
SOURCE (Princeton)COPS3
Genetics Home Reference (NIH)COPS3
Genomic and cartography
GoldenPath hg38 (UCSC)COPS3  -     chr17:17246616-17281246 -  17p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)COPS3  -     17p11.2   [Description]    (hg19-Feb_2009)
GoldenPathCOPS3 - 17p11.2 [CytoView hg19]  COPS3 - 17p11.2 [CytoView hg38]
ImmunoBaseENSG00000141030
Genome Data Viewer NCBICOPS3 [Mapview hg19]  
OMIM604665   
Gene and transcription
Genbank (Entrez)AF031647 AF098109 AK297706 AK302304 AK312476
RefSeq transcript (Entrez)NM_001199125 NM_001316354 NM_001316355 NM_001316356 NM_001316357 NM_001316358 NM_003653
Consensus coding sequences : CCDS (NCBI)COPS3
Gene ExpressionCOPS3 [ NCBI-GEO ]   COPS3 [ EBI - ARRAY_EXPRESS ]   COPS3 [ SEEK ]   COPS3 [ MEM ]
Gene Expression Viewer (FireBrowse)COPS3 [ Firebrowse - Broad ]
GenevisibleExpression of COPS3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8533
GTEX Portal (Tissue expression)COPS3
Human Protein AtlasENSG00000141030-COPS3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UNS2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UNS2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UNS2
PhosPhoSitePlusQ9UNS2
Domaine pattern : Prosite (Expaxy)PCI (PS50250)   
Domains : Interpro (EBI)CSN3    PCI_dom    WH-like_DNA-bd_sf    WH_DNA-bd_sf   
Domain families : Pfam (Sanger)PCI (PF01399)   
Domain families : Pfam (NCBI)pfam01399   
Domain families : Smart (EMBL)PINT (SM00088)  
Conserved Domain (NCBI)COPS3
PDB (RSDB)4D10    4D18    4WSN    6R6H    6R7F    6R7H    6R7I    6R7N   
PDB Europe4D10    4D18    4WSN    6R6H    6R7F    6R7H    6R7I    6R7N   
PDB (PDBSum)4D10    4D18    4WSN    6R6H    6R7F    6R7H    6R7I    6R7N   
PDB (IMB)4D10    4D18    4WSN    6R6H    6R7F    6R7H    6R7I    6R7N   
Structural Biology KnowledgeBase4D10    4D18    4WSN    6R6H    6R7F    6R7H    6R7I    6R7N   
SCOP (Structural Classification of Proteins)4D10    4D18    4WSN    6R6H    6R7F    6R7H    6R7I    6R7N   
CATH (Classification of proteins structures)4D10    4D18    4WSN    6R6H    6R7F    6R7H    6R7I    6R7N   
SuperfamilyQ9UNS2
AlphaFold pdb e-kbQ9UNS2   
Human Protein Atlas [tissue]ENSG00000141030-COPS3 [tissue]
HPRD07262
Protein Interaction databases
DIP (DOE-UCLA)Q9UNS2
IntAct (EBI)Q9UNS2
BioGRIDCOPS3
STRING (EMBL)COPS3
ZODIACCOPS3
Ontologies - Pathways
QuickGOQ9UNS2
Ontology : AmiGOprotein deneddylation  in utero embryonic development  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  cytosol  ubiquitin-dependent protein catabolic process  signal transduction  COP9 signalosome  COP9 signalosome  COP9 signalosome  response to light stimulus  perinuclear region of cytoplasm  regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator  
Ontology : EGO-EBIprotein deneddylation  in utero embryonic development  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  cytosol  ubiquitin-dependent protein catabolic process  signal transduction  COP9 signalosome  COP9 signalosome  COP9 signalosome  response to light stimulus  perinuclear region of cytoplasm  regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator  
NDEx NetworkCOPS3
Atlas of Cancer Signalling NetworkCOPS3
Wikipedia pathwaysCOPS3
Orthology - Evolution
OrthoDB8533
GeneTree (enSembl)ENSG00000141030
Phylogenetic Trees/Animal Genes : TreeFamCOPS3
Homologs : HomoloGeneCOPS3
Homology/Alignments : Family Browser (UCSC)COPS3
Gene fusions - Rearrangements
Fusion : MitelmanCOPS3::TEKT3 [17p11.2/17p12]  
Fusion : QuiverCOPS3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCOPS3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)COPS3
dbVarCOPS3
ClinVarCOPS3
MonarchCOPS3
1000_GenomesCOPS3 
Exome Variant ServerCOPS3
GNOMAD BrowserENSG00000141030
Varsome BrowserCOPS3
ACMGCOPS3 variants
VarityQ9UNS2
Genomic Variants (DGV)COPS3 [DGVbeta]
DECIPHERCOPS3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCOPS3 
Mutations
ICGC Data PortalCOPS3 
TCGA Data PortalCOPS3 
Broad Tumor PortalCOPS3
OASIS PortalCOPS3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCOPS3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCOPS3
Mutations and Diseases : HGMDCOPS3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCOPS3
DgiDB (Drug Gene Interaction Database)COPS3
DoCM (Curated mutations)COPS3
CIViC (Clinical Interpretations of Variants in Cancer)COPS3
Cancer3DCOPS3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604665   
Orphanet
DisGeNETCOPS3
MedgenCOPS3
Genetic Testing Registry COPS3
NextProtQ9UNS2 [Medical]
GENETestsCOPS3
Target ValidationCOPS3
Huge Navigator COPS3 [HugePedia]
ClinGenCOPS3
Clinical trials, drugs, therapy
MyCancerGenomeCOPS3
Protein Interactions : CTDCOPS3
Pharm GKB GenePA26755
PharosQ9UNS2
Clinical trialCOPS3
Miscellaneous
canSAR (ICR)COPS3
HarmonizomeCOPS3
ARCHS4COPS3
DataMed IndexCOPS3
Probes
Litterature
PubMed136 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCOPS3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Jan 20 12:28:33 CET 2022

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