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COPS4 (COP9 signalosome subunit 4)

Identity

Alias_namesCOP9 (constitutive photomorphogenic, Arabidopsis, homolog) subunit 4
COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)
Alias_symbol (synonym)CSN4
Other aliasSGN4
HGNC (Hugo) COPS4
LocusID (NCBI) 51138
Atlas_Id 40133
Location 4q21.22  [Link to chromosome band 4q21]
Location_base_pair Starts at 83035086 and ends at 83075818 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
SNRNP25 (16p13.3) / COPS4 (4q21.22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

=TR>¼TD$WIDTH=15%>Domain families : Pfam (Sanger)
Nomenclature
HGNC (Hugo)COPS4   16702
Cards
Entrez_Gene (NCBI)COPS4  51138  COP9 signalosome subunit 4
AliasesCSN4; SGN4
GeneCards (Weizmann)COPS4
Ensembl hg19 (Hinxton)ENSG00000138663 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138663 [Gene_View]  chr4:83035086-83075818 [Contig_View]  COPS4 [Vega]
ICGC DataPortalENSG00000138663
TCGA cBioPortalCOPS4
AceView (NCBI)COPS4
Genatlas (Paris)COPS4
WikiGenes51138
SOURCE (Princeton)COPS4
Genetics Home Reference (NIH)COPS4
Genomic and cartography
GoldenPath hg38 (UCSC)COPS4  -     chr4:83035086-83075818 +  4q21.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)COPS4  -     4q21.22   [Description]    (hg19-Feb_2009)
EnsemblCOPS4 - 4q21.22 [CytoView hg19]  COPS4 - 4q21.22 [CytoView hg38]
Mapping of homologs : NCBICOPS4 [Mapview hg19]  COPS4 [Mapview hg38]
OMIM616008   
Gene and transcription
Genbank (Entrez)AF100757 AK001148 AK001210 AK024005 AK094238
RefSeq transcript (Entrez)NM_001258006 NM_001330727 NM_016129
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)COPS4
Cluster EST : UnigeneHs.190384 [ NCBI ]
CGAP (NCI)Hs.190384
Alternative Splicing GalleryENSG00000138663
Gene ExpressionCOPS4 [ NCBI-GEO ]   COPS4 [ EBI - ARRAY_EXPRESS ]   COPS4 [ SEEK ]   COPS4 [ MEM ]
Gene Expression Viewer (FireBrowse)COPS4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51138
GTEX Portal (Tissue expression)COPS4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BT78   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BT78  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BT78
Splice isoforms : SwissVarQ9BT78
PhosPhoSitePlusQ9BT78
Domains : Interpro (EBI)PCI_dom    WHTH_DNA-bd_dom   
PCI (PF01399)   
Domain families : Pfam (NCBI)pfam01399   
Domain families : Smart (EMBL)PINT (SM00088)  
Conserved Domain (NCBI)COPS4
DMDM Disease mutations51138
Blocks (Seattle)COPS4
PDB (SRS)4D0P    4D10    4D18    4WSN   
PDB (PDBSum)4D0P    4D10    4D18    4WSN   
PDB (IMB)4D0P    4D10    4D18    4WSN   
PDB (RSDB)4D0P    4D10    4D18    4WSN   
Structural Biology KnowledgeBase4D0P    4D10    4D18    4WSN   
SCOP (Structural Classification of Proteins)4D0P    4D10    4D18    4WSN   
CATH (Classification of proteins structures)4D0P    4D10    4D18    4WSN   
SuperfamilyQ9BT78
Human Protein AtlasENSG00000138663
Peptide AtlasQ9BT78
HPRD09888
IPIIPI00171844   IPI00966482   IPI00967027   IPI00966770   IPI00965682   IPI00966084   
Protein Interaction databases
DIP (DOE-UCLA)Q9BT78
IntAct (EBI)Q9BT78
FunCoupENSG00000138663
BioGRIDCOPS4
STRING (EMBL)COPS4
ZODIACCOPS4
Ontologies - Pathways
QuickGOQ9BT78
Ontology : AmiGOprotein deneddylation  protein deneddylation  nucleotide-excision repair, DNA damage recognition  protein binding  nucleus  nucleoplasm  cytosol  cytosol  transcription-coupled nucleotide-excision repair  synaptic vesicle  COP9 signalosome  nuclear speck  NEDD8-specific protease activity  NEDD8-specific protease activity  cell junction  extracellular exosome  
Ontology : EGO-EBIprotein deneddylation  +protein deneddylation  nucleotide-excision repair, DNA damage recognition  protein binding  nucleus  nucleoplasm  cytosol  cytosol  transcription-coupled nucleotide-excision repair  synaptic vesicle  COP9 signalosome  nuclear speck  NEDD8-specific protease activity  NEDD8-specific protease activity  cell junction  extracellular exosome  
NDEx NetworkCOPS4
Atlas of Cancer Signalling NetworkCOPS4
Wikipedia pathwaysCOPS4
Orthology - Evolution
OrthoDB51138
GeneTree (enSembl)ENSG00000138663
Phylogenetic Trees/Animal Genes : TreeFamCOPS4
HOVERGENQ9BT78
HOGENOMQ9BT78
Homologs : HomoloGeneCOPS4
Homology/Alignments : Family Browser (UCSC)COPS4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCOPS4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)COPS4
dbVarCOPS4
ClinVarCOPS4
1000_GenomesCOPS4 
Exome Variant ServerCOPS4
ExAC (Exome Aggregation Consortium)COPS4 (select the gene name)
Genetic variants : HAPMAP51138
Genomic Variants (DGV)COPS4 [DGVbeta]
DECIPHERCOPS4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCOPS4 
Mutations
ICGC Data PortalCOPS4 
TCGA Data PortalCOPS4 
Broad Tumor PortalCOPS4
OASIS PortalCOPS4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCOPS4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCOPS4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch COPS4
DgiDB (Drug Gene Interaction Database)COPS4
DoCM (Curated mutations)COPS4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)COPS4 (select a term)
intoGenCOPS4
Cancer3DCOPS4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616008   
Orphanet
MedgenCOPS4
Genetic Testing Registry COPS4
NextProtQ9BT78 [Medical]
TSGene51138
GENETestsCOPS4
Target ValidationCOPS4
Huge Navigator COPS4 [HugePedia]
snp3D : Map Gene to Disease51138
BioCentury BCIQCOPS4
ClinGenCOPS4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51138
Chemical/Pharm GKB GenePA26756
Clinical trialCOPS4
Miscellaneous
canSAR (ICR)COPS4 (select the gene name)
Probes
Litterature
PubMed81 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCOPS4
EVEXCOPS4
GoPubMedCOPS4
iHOPCOPS4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:50:25 CEST 2017

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