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COPS5 (COP9 signalosome subunit 5)

Identity

Alias_namesCOP9 (constitutive photomorphogenic, Arabidopsis, homolog) subunit 5
COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)
Alias_symbol (synonym)JAB1
SGN5
MOV-34
CSN5
Other alias
HGNC (Hugo) COPS5
LocusID (NCBI) 10987
Atlas_Id 45824
Location 8q13.1  [Link to chromosome band 8q13]
Location_base_pair Starts at 67043080 and ends at 67062327 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
COPS5 (8q13.1) / COPS5 (8q13.1)COPS5 (8q13.1) / HNRNPH3 (10q21.3)PDE7A (8q13.1) / COPS5 (8q13.1)
TPD52 (8q21.13) / COPS5 (8q13.1)PDE7A 8q13.1 / COPS5 8q13.1TPD52 8q21.13 / COPS5 8q13.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)COPS5   2240
Cards
Entrez_Gene (NCBI)COPS5  10987  COP9 signalosome subunit 5
AliasesCSN5; JAB1; MOV-34; SGN5
GeneCards (Weizmann)COPS5
Ensembl hg19 (Hinxton)ENSG00000121022 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000121022 [Gene_View]  chr8:67043080-67062327 [Contig_View]  COPS5 [Vega]
ICGC DataPortalENSG00000121022
TCGA cBioPortalCOPS5
AceView (NCBI)COPS5
Genatlas (Paris)COPS5
WikiGenes10987
SOURCE (Princeton)COPS5
Genetics Home Reference (NIH)COPS5
Genomic and cartography
GoldenPath hg38 (UCSC)COPS5  -     chr8:67043080-67062327 -  8q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)COPS5  -     8q13.1   [Description]    (hg19-Feb_2009)
EnsemblCOPS5 - 8q13.1 [CytoView hg19]  COPS5 - 8q13.1 [CytoView hg38]
Mapping of homologs : NCBICOPS5 [Mapview hg19]  COPS5 [Mapview hg38]
OMIM604850   
Gene and transcription
Genbank (Entrez)AA203444 AB209134 AK056967 AK128519 AK310434
RefSeq transcript (Entrez)NM_006837
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)COPS5
Cluster EST : UnigeneHs.491912 [ NCBI ]
CGAP (NCI)Hs.491912
Alternative Splicing GalleryENSG00000121022
Gene ExpressionCOPS5 [ NCBI-GEO ]   COPS5 [ EBI - ARRAY_EXPRESS ]   COPS5 [ SEEK ]   COPS5 [ MEM ]
Gene Expression Viewer (FireBrowse)COPS5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10987
GTEX Portal (Tissue expression)COPS5
Human Protein AtlasENSG00000121022-COPS5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92905   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92905  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92905
Splice isoforms : SwissVarQ92905
Catalytic activity : Enzyme3.4.-.- [ Enzyme-Expasy ]   3.4.-.-3.4.-.- [ IntEnz-EBI ]   3.4.-.- [ BRENDA ]   3.4.-.- [ KEGG ]   
PhosPhoSitePlusQ92905
Domains : Interpro (EBI)JAMM/MPN+_dom   
Domain families : Pfam (Sanger)JAB (PF01398)   
Domain families : Pfam (NCBI)pfam01398   
Domain families : Smart (EMBL)JAB_MPN (SM00232)  
Conserved Domain (NCBI)COPS5
DMDM Disease mutations10987
Blocks (Seattle)COPS5
PDB (SRS)4D10    4D18    4F7O    4WSN    5JOG    5JOH    5M5Q   
PDB (PDBSum)4D10    4D18    4F7O    4WSN    5JOG    5JOH    5M5Q   
PDB (IMB)4D10    4D18    4F7O    4WSN    5JOG    5JOH    5M5Q   
PDB (RSDB)4D10    4D18    4F7O    4WSN    5JOG    5JOH    5M5Q   
Structural Biology KnowledgeBase4D10    4D18    4F7O    4WSN    5JOG    5JOH    5M5Q   
SCOP (Structural Classification of Proteins)4D10    4D18    4F7O    4WSN    5JOG    5JOH    5M5Q   
CATH (Classification of proteins structures)4D10    4D18    4F7O    4WSN    5JOG    5JOH    5M5Q   
SuperfamilyQ92905
Human Protein Atlas [tissue]ENSG00000121022-COPS5 [tissue]
Peptide AtlasQ92905
HPRD06888
IPIIPI00009958   IPI00791215   IPI00985306   IPI01011570   IPI00980479   IPI00974152   
Protein Interaction databases
DIP (DOE-UCLA)Q92905
IntAct (EBI)Q92905
FunCoupENSG00000121022
BioGRIDCOPS5
STRING (EMBL)COPS5
ZODIACCOPS5
Ontologies - Pathways
QuickGOQ92905
Ontology : AmiGOprotein deneddylation  protein deneddylation  nucleotide-excision repair, DNA damage recognition  transcription coactivator activity  translation initiation factor activity  thiol-dependent ubiquitin-specific protease activity  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  eukaryotic translation initiation factor 3 complex  transcription-coupled nucleotide-excision repair  transcription from RNA polymerase II promoter  translation  translational initiation  synaptic vesicle  COP9 signalosome  metallopeptidase activity  protein deubiquitination  cell junction  positive regulation of transcription from RNA polymerase II promoter  regulation of JNK cascade  metal ion binding  perinuclear region of cytoplasm  regulation of cell cycle  regulation of IRE1-mediated unfolded protein response  exosomal secretion  
Ontology : EGO-EBIprotein deneddylation  protein deneddylation  nucleotide-excision repair, DNA damage recognition  transcription coactivator activity  translation initiation factor activity  thiol-dependent ubiquitin-specific protease activity  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  eukaryotic translation initiation factor 3 complex  transcription-coupled nucleotide-excision repair  transcription from RNA polymerase II promoter  translation  translational initiation  synaptic vesicle  COP9 signalosome  metallopeptidase activity  protein deubiquitination  cell junction  positive regulation of transcription from RNA polymerase II promoter  regulation of JNK cascade  metal ion binding  perinuclear region of cytoplasm  regulation of cell cycle  regulation of IRE1-mediated unfolded protein response  exosomal secretion  
Pathways : BIOCARTAHypoxia-Inducible Factor in the Cardiovascular System [Genes]   
NDEx NetworkCOPS5
Atlas of Cancer Signalling NetworkCOPS5
Wikipedia pathwaysCOPS5
Orthology - Evolution
OrthoDB10987
GeneTree (enSembl)ENSG00000121022
Phylogenetic Trees/Animal Genes : TreeFamCOPS5
HOVERGENQ92905
HOGENOMQ92905
Homologs : HomoloGeneCOPS5
Homology/Alignments : Family Browser (UCSC)COPS5
Gene fusions - Rearrangements
Fusion : MitelmanPDE7A/COPS5 [8q13.1/8q13.1]  [t(8;8)(q13;q13)]  
Fusion : MitelmanTPD52/COPS5 [8q21.13/8q13.1]  [t(8;8)(q13;q21)]  
Fusion: TCGA_MDACCPDE7A 8q13.1 COPS5 8q13.1 BRCA
Fusion: TCGA_MDACCTPD52 8q21.13 COPS5 8q13.1 BRCA
Tumor Fusion PortalCOPS5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCOPS5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)COPS5
dbVarCOPS5
ClinVarCOPS5
1000_GenomesCOPS5 
Exome Variant ServerCOPS5
ExAC (Exome Aggregation Consortium)ENSG00000121022
GNOMAD BrowserENSG00000121022
Genetic variants : HAPMAP10987
Genomic Variants (DGV)COPS5 [DGVbeta]
DECIPHERCOPS5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCOPS5 
Mutations
ICGC Data PortalCOPS5 
TCGA Data PortalCOPS5 
Broad Tumor PortalCOPS5
OASIS PortalCOPS5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCOPS5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCOPS5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch COPS5
DgiDB (Drug Gene Interaction Database)COPS5
DoCM (Curated mutations)COPS5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)COPS5 (select a term)
intoGenCOPS5
Cancer3DCOPS5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604850   
Orphanet
DisGeNETCOPS5
MedgenCOPS5
Genetic Testing Registry COPS5
NextProtQ92905 [Medical]
TSGene10987
GENETestsCOPS5
Target ValidationCOPS5
Huge Navigator COPS5 [HugePedia]
snp3D : Map Gene to Disease10987
BioCentury BCIQCOPS5
ClinGenCOPS5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10987
Chemical/Pharm GKB GenePA26757
Clinical trialCOPS5
Miscellaneous
canSAR (ICR)COPS5 (select the gene name)
Probes
Litterature
PubMed211 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCOPS5
EVEXCOPS5
GoPubMedCOPS5
iHOPCOPS5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:08:37 CET 2017

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