COPS5 (COP9 signalosome subunit 5)

2007-02-01 Affiliation

Identity

HGNC

COPS5

LOCATION

8q13.1

LOCUSID

10987

ALIAS

CSN5,JAB1,MOV-34,SGN5

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10987
MIM: 604850
HGNC: 2240
Ensembl: ENSG00000121022

Variants:

dbSNP: 10987
ClinVar: 10987
TCGA: ENSG00000121022
COSMIC: COPS5

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000121022	ENST00000357849	Q92905
ENSG00000121022	ENST00000357849	A0A024R7W9
ENSG00000121022	ENST00000517406	E5RK55
ENSG00000121022	ENST00000517736	E5RHH5
ENSG00000121022	ENST00000518374	E5RG35
ENSG00000121022	ENST00000518747	E5RHF2
ENSG00000121022	ENST00000523890	E5RFS1

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Vesicle-mediated transport	REACTOME	R-HSA-5653656
Membrane Trafficking	REACTOME	R-HSA-199991
DNA Repair	REACTOME	R-HSA-73894
Nucleotide Excision Repair	REACTOME	R-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)	REACTOME	R-HSA-5696399
DNA Damage Recognition in GG-NER	REACTOME	R-HSA-5696394
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	REACTOME	R-HSA-6781827
Formation of TC-NER Pre-Incision Complex	REACTOME	R-HSA-6781823
Clathrin-mediated endocytosis	REACTOME	R-HSA-8856828
Cargo recognition for clathrin-mediated endocytosis	REACTOME	R-HSA-8856825

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
16122907	2006	Rapid and transient activation of the ERK MAPK signalling pathway by macrophage migration inhibitory factor (MIF) and dependence on JAB1/CSN5 and Src kinase activity.	62
16000397	2005	Array-based comparative genomic hybridization reveals recurrent chromosomal aberrations and Jab1 as a potential target for 8q gain in hepatocellular carcinoma.	41
16624822	2006	Jab1 induces the cytoplasmic localization and degradation of p53 in coordination with Hdm2.	41
14993265	2004	Jab1/CSN5, a component of the COP9 signalosome, regulates transforming growth factor beta signaling by binding to Smad7 and promoting its degradation.	39
16882664	2006	Jab1 mediates cytoplasmic localization and degradation of West Nile virus capsid protein.	35
17879958	2008	Roles for CSN5 in control of p53/MDM2 activities.	33
15899841	2005	CSN5/Jab1 is involved in ligand-dependent degradation of estrogen receptor {alpha} by the proteasome.	31
22797071	2013	Suppression of Jab1/CSN5 induces radio- and chemo-sensitivity in nasopharyngeal carcinoma through changes to the DNA damage and repair pathways.	31
23288897	2013	Insights into the regulation of the human COP9 signalosome catalytic subunit, CSN5/Jab1.	31
15353483	2005	The Jab1/COP9 signalosome subcomplex is a downstream mediator of Bcr-Abl kinase activity and facilitates cell-cycle progression.	28

Citation

Dessen P

COPS5 (COP9 signalosome subunit 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45824/cops5