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COPS6 (COP9 signalosome subunit 6)

Identity

Alias_names34 kD)
Alias_symbol (synonym)MOV34-34KD
CSN6
Other alias
HGNC (Hugo) COPS6
LocusID (NCBI) 10980
Atlas_Id 47367
Location 7q22.1  [Link to chromosome band 7q22]
Location_base_pair Starts at 100088960 and ends at 100092199 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PLPPR2 (19p13.2) / COPS6 (7q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)COPS6   21749
Cards
Entrez_Gene (NCBI)COPS6  10980  COP9 signalosome subunit 6
AliasesCSN6; MOV34-34KD
GeneCards (Weizmann)COPS6
Ensembl hg19 (Hinxton)ENSG00000168090 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168090 [Gene_View]  chr7:100088960-100092199 [Contig_View]  COPS6 [Vega]
ICGC DataPortalENSG00000168090
TCGA cBioPortalCOPS6
AceView (NCBI)COPS6
Genatlas (Paris)COPS6
WikiGenes10980
SOURCE (Princeton)COPS6
Genetics Home Reference (NIH)COPS6
Genomic and cartography
GoldenPath hg38 (UCSC)COPS6  -     chr7:100088960-100092199 +  7q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)COPS6  -     7q22.1   [Description]    (hg19-Feb_2009)
EnsemblCOPS6 - 7q22.1 [CytoView hg19]  COPS6 - 7q22.1 [CytoView hg38]
Mapping of homologs : NCBICOPS6 [Mapview hg19]  COPS6 [Mapview hg38]
OMIM614729   
Gene and transcription
Genbank (Entrez)AK295237 AK312024 BC002520 BI113801 CB990467
RefSeq transcript (Entrez)NM_006833
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)COPS6
Cluster EST : UnigeneHs.15591 [ NCBI ]
CGAP (NCI)Hs.15591
Alternative Splicing GalleryENSG00000168090
Gene ExpressionCOPS6 [ NCBI-GEO ]   COPS6 [ EBI - ARRAY_EXPRESS ]   COPS6 [ SEEK ]   COPS6 [ MEM ]
Gene Expression Viewer (FireBrowse)COPS6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10980
GTEX Portal (Tissue expression)COPS6
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7L5N1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7L5N1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7L5N1
Splice isoforms : SwissVarQ7L5N1
PhosPhoSitePlusQ7L5N1
Domains : Interpro (EBI)JAMM/MPN+_dom    MPN_CSN6    Rpn11/EIF3F_C   
Domain families : Pfam (Sanger)JAB (PF01398)    MitMem_reg (PF13012)   
Domain families : Pfam (NCBI)pfam01398    pfam13012   
Domain families : Smart (EMBL)JAB_MPN (SM00232)  
Conserved Domain (NCBI)COPS6
DMDM Disease mutations10980
Blocks (Seattle)COPS6
PDB (SRS)4D10    4D18    4QFT    4R14    4WSN   
PDB (PDBSum)4D10    4D18    4QFT    4R14    4WSN   
PDB (IMB)4D10    4D18    4QFT    4R14    4WSN   
PDB (RSDB)4D10    4D18    4QFT    4R14    4WSN   
Structural Biology KnowledgeBase4D10    4D18    4QFT    4R14    4WSN   
SCOP (Structural Classification of Proteins)4D10    4D18    4QFT    4R14    4WSN   
CATH (Classification of proteins structures)4D10    4D18    4QFT    4R14    4WSN   
SuperfamilyQ7L5N1
Human Protein AtlasENSG00000168090
Peptide AtlasQ7L5N1
HPRD16735
IPIIPI00163230   IPI00924791   IPI01021789   IPI00925574   
Protein Interaction databases
DIP (DOE-UCLA)Q7L5N1
IntAct (EBI)Q7L5N1
FunCoupENSG00000168090
BioGRIDCOPS6
STRING (EMBL)COPS6
ZODIACCOPS6
Ontologies - Pathways
QuickGOQ7L5N1
Ontology : AmiGOprotein deneddylation  nucleotide-excision repair, DNA damage recognition  protein binding  nucleoplasm  nucleoplasm  cytosol  transcription-coupled nucleotide-excision repair  COP9 signalosome  viral process  extracellular exosome  
Ontology : EGO-EBIprotein deneddylation  nucleotide-excision repair, DNA damage recognition  protein binding  nucleoplasm  nucleoplasm  cytosol  transcription-coupled nucleotide-excision repair  COP9 signalosome  viral process  extracellular exosome  
NDEx NetworkCOPS6
Atlas of Cancer Signalling NetworkCOPS6
Wikipedia pathwaysCOPS6
Orthology - Evolution
OrthoDB10980
GeneTree (enSembl)ENSG00000168090
Phylogenetic Trees/Animal Genes : TreeFamCOPS6
HOVERGENQ7L5N1
HOGENOMQ7L5N1
Homologs : HomoloGeneCOPS6
Homology/Alignments : Family Browser (UCSC)COPS6
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCOPS6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)COPS6
dbVarCOPS6
ClinVarCOPS6
1000_GenomesCOPS6 
Exome Variant ServerCOPS6
ExAC (Exome Aggregation Consortium)COPS6 (select the gene name)
Genetic variants : HAPMAP10980
Genomic Variants (DGV)COPS6 [DGVbeta]
DECIPHERCOPS6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCOPS6 
Mutations
ICGC Data PortalCOPS6 
TCGA Data PortalCOPS6 
Broad Tumor PortalCOPS6
OASIS PortalCOPS6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCOPS6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCOPS6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch COPS6
DgiDB (Drug Gene Interaction Database)COPS6
DoCM (Curated mutations)COPS6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)COPS6 (select a term)
intoGenCOPS6
Cancer3DCOPS6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614729   
Orphanet
MedgenCOPS6
Genetic Testing Registry COPS6
NextProtQ7L5N1 [Medical]
TSGene10980
GENETestsCOPS6
Huge Navigator COPS6 [HugePedia]
snp3D : Map Gene to Disease10980
BioCentury BCIQCOPS6
ClinGenCOPS6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10980
Chemical/Pharm GKB GenePA134919933
Clinical trialCOPS6
Miscellaneous
canSAR (ICR)COPS6 (select the gene name)
Probes
Litterature
PubMed86 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCOPS6
EVEXCOPS6
GoPubMedCOPS6
iHOPCOPS6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:11:26 CEST 2017

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