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COPS8 (COP9 signalosome subunit 8)

Identity

Alias_namesCOP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)
Alias_symbol (synonym)COP9
CSN8
MGC1297
SGN8
Other alias
HGNC (Hugo) COPS8
LocusID (NCBI) 10920
Atlas_Id 53242
Location 2q37.3  [Link to chromosome band 2q37]
Location_base_pair Starts at 237085441 and ends at 237098846 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CLTC (17q23.1) / COPS8 (2q37.3)COPS8 (2q37.3) / FAM19A1 (3p14.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)COPS8   24335
Cards
Entrez_Gene (NCBI)COPS8  10920  COP9 signalosome subunit 8
AliasesCOP9; CSN8; SGN8
GeneCards (Weizmann)COPS8
Ensembl hg19 (Hinxton)ENSG00000198612 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198612 [Gene_View]  chr2:237085441-237098846 [Contig_View]  COPS8 [Vega]
ICGC DataPortalENSG00000198612
TCGA cBioPortalCOPS8
AceView (NCBI)COPS8
Genatlas (Paris)COPS8
WikiGenes10920
SOURCE (Princeton)COPS8
Genetics Home Reference (NIH)COPS8
Genomic and cartography
GoldenPath hg38 (UCSC)COPS8  -     chr2:237085441-237098846 +  2q37.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)COPS8  -     2q37.3   [Description]    (hg19-Feb_2009)
EnsemblCOPS8 - 2q37.3 [CytoView hg19]  COPS8 - 2q37.3 [CytoView hg38]
Mapping of homologs : NCBICOPS8 [Mapview hg19]  COPS8 [Mapview hg38]
OMIM616011   
Gene and transcription
Genbank (Entrez)AA004869 AI077560 AI690743 AK289891 AK294078
RefSeq transcript (Entrez)NM_006710 NM_198189
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)COPS8
Cluster EST : UnigeneHs.531713 [ NCBI ]
CGAP (NCI)Hs.531713
Alternative Splicing GalleryENSG00000198612
Gene ExpressionCOPS8 [ NCBI-GEO ]   COPS8 [ EBI - ARRAY_EXPRESS ]   COPS8 [ SEEK ]   COPS8 [ MEM ]
Gene Expression Viewer (FireBrowse)COPS8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10920
GTEX Portal (Tissue expression)COPS8
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99627   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99627  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99627
Splice isoforms : SwissVarQ99627
PhosPhoSitePlusQ99627
Domains : Interpro (EBI)COP9_CSN8    CSN8_PSD8_EIF3K   
Domain families : Pfam (Sanger)CSN8_PSD8_EIF3K (PF10075)   
Domain families : Pfam (NCBI)pfam10075   
Conserved Domain (NCBI)COPS8
DMDM Disease mutations10920
Blocks (Seattle)COPS8
PDB (SRS)4D10    4D18    4WSN   
PDB (PDBSum)4D10    4D18    4WSN   
PDB (IMB)4D10    4D18    4WSN   
PDB (RSDB)4D10    4D18    4WSN   
Structural Biology KnowledgeBase4D10    4D18    4WSN   
SCOP (Structural Classification of Proteins)4D10    4D18    4WSN   
CATH (Classification of proteins structures)4D10    4D18    4WSN   
SuperfamilyQ99627
Human Protein AtlasENSG00000198612
Peptide AtlasQ99627
HPRD16737
IPIIPI00009480   IPI00377080   IPI00916030   IPI00916216   IPI00915801   IPI00916489   
Protein Interaction databases
DIP (DOE-UCLA)Q99627
IntAct (EBI)Q99627
FunCoupENSG00000198612
BioGRIDCOPS8
STRING (EMBL)COPS8
ZODIACCOPS8
Ontologies - Pathways
QuickGOQ99627
Ontology : AmiGOprotein deneddylation  nucleotide-excision repair, DNA damage recognition  protein binding  nucleus  nucleoplasm  nucleoplasm  cytosol  cytosol  transcription-coupled nucleotide-excision repair  activation of NF-kappaB-inducing kinase activity  COP9 signalosome  negative regulation of cell proliferation  COP9 signalosome assembly  perinuclear region of cytoplasm  extracellular exosome  
Ontology : EGO-EBIprotein deneddylation  nucleotide-excision repair, DNA damage recognition  protein binding  nucleus  nucleoplasm  nucleoplasm  cytosol  cytosol  transcription-coupled nucleotide-excision repair  activation of NF-kappaB-inducing kinase activity  COP9 signalosome  negative regulation of cell proliferation  COP9 signalosome assembly  perinuclear region of cytoplasm  extracellular exosome  
NDEx NetworkCOPS8
Atlas of Cancer Signalling NetworkCOPS8
Wikipedia pathwaysCOPS8
Orthology - Evolution
OrthoDB10920
GeneTree (enSembl)ENSG00000198612
Phylogenetic Trees/Animal Genes : TreeFamCOPS8
HOVERGENQ99627
HOGENOMQ99627
Homologs : HomoloGeneCOPS8
Homology/Alignments : Family Browser (UCSC)COPS8
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCOPS8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)COPS8
dbVarCOPS8
ClinVarCOPS8
1000_GenomesCOPS8 
Exome Variant ServerCOPS8
ExAC (Exome Aggregation Consortium)COPS8 (select the gene name)
Genetic variants : HAPMAP10920
Genomic Variants (DGV)COPS8 [DGVbeta]
DECIPHERCOPS8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCOPS8 
Mutations
ICGC Data PortalCOPS8 
TCGA Data PortalCOPS8 
Broad Tumor PortalCOPS8
OASIS PortalCOPS8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCOPS8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCOPS8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch COPS8
DgiDB (Drug Gene Interaction Database)COPS8
DoCM (Curated mutations)COPS8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)COPS8 (select a term)
intoGenCOPS8
Cancer3DCOPS8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616011   
Orphanet
MedgenCOPS8
Genetic Testing Registry COPS8
NextProtQ99627 [Medical]
TSGene10920
GENETestsCOPS8
Target ValidationCOPS8
Huge Navigator COPS8 [HugePedia]
snp3D : Map Gene to Disease10920
BioCentury BCIQCOPS8
ClinGenCOPS8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10920
Chemical/Pharm GKB GenePA134968686
Clinical trialCOPS8
Miscellaneous
canSAR (ICR)COPS8 (select the gene name)
Probes
Litterature
PubMed74 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCOPS8
EVEXCOPS8
GoPubMedCOPS8
iHOPCOPS8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:29:14 CEST 2017

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