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CORIN (corin, serine peptidase)

Identity

Alias_namescorin, serine protease
Alias_symbol (synonym)PRSC
CRN
ATC2
Lrp4
TMPRSS10
Other aliasPEE5
HGNC (Hugo) CORIN
LocusID (NCBI) 10699
Atlas_Id 62031
Location 4p12  [Link to chromosome band 4p12]
Location_base_pair Starts at 47593998 and ends at 47838106 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CORIN (4p12) / HECW2 (2q32.3)MEMO1 (2p23.1) / CORIN (4p12)OSBPL3 (7p15.3) / CORIN (4p12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CORIN   19012
Cards
Entrez_Gene (NCBI)CORIN  10699  corin, serine peptidase
AliasesATC2; CRN; Lrp4; PEE5; 
TMPRSS10
GeneCards (Weizmann)CORIN
Ensembl hg19 (Hinxton)ENSG00000145244 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000145244 [Gene_View]  chr4:47593998-47838106 [Contig_View]  CORIN [Vega]
ICGC DataPortalENSG00000145244
TCGA cBioPortalCORIN
AceView (NCBI)CORIN
Genatlas (Paris)CORIN
WikiGenes10699
SOURCE (Princeton)CORIN
Genetics Home Reference (NIH)CORIN
Genomic and cartography
GoldenPath hg38 (UCSC)CORIN  -     chr4:47593998-47838106 -  4p12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CORIN  -     4p12   [Description]    (hg19-Feb_2009)
EnsemblCORIN - 4p12 [CytoView hg19]  CORIN - 4p12 [CytoView hg38]
Mapping of homologs : NCBICORIN [Mapview hg19]  CORIN [Mapview hg38]
OMIM605236   614595   
Gene and transcription
Genbank (Entrez)AF113248 AF133845 AI338960 AI378383 AI872582
RefSeq transcript (Entrez)NM_001278585 NM_001278586 NM_006587
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CORIN
Cluster EST : UnigeneHs.604887 [ NCBI ]
CGAP (NCI)Hs.604887
Alternative Splicing GalleryENSG00000145244
Gene ExpressionCORIN [ NCBI-GEO ]   CORIN [ EBI - ARRAY_EXPRESS ]   CORIN [ SEEK ]   CORIN [ MEM ]
Gene Expression Viewer (FireBrowse)CORIN [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10699
GTEX Portal (Tissue expression)CORIN
Human Protein AtlasENSG00000145244-CORIN [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y5Q5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y5Q5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y5Q5
Splice isoforms : SwissVarQ9Y5Q5
Catalytic activity : Enzyme3.4.21.- [ Enzyme-Expasy ]   3.4.21.-3.4.21.- [ IntEnz-EBI ]   3.4.21.- [ BRENDA ]   3.4.21.- [ KEGG ]   
PhosPhoSitePlusQ9Y5Q5
Domaine pattern : Prosite (Expaxy)FZ (PS50038)    LDLRA_1 (PS01209)    LDLRA_2 (PS50068)    SRCR_1 (PS00420)    TRYPSIN_DOM (PS50240)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)Corin    Frizzled_dom    LDLR_class-A_CS    LDrepeatLR_classA_rpt    Peptidase_S1_PA    SRCR-like_dom    Trypsin_dom    TRYPSIN_SER   
Domain families : Pfam (Sanger)Fz (PF01392)    Ldl_recept_a (PF00057)    SRCR_2 (PF15494)    Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam01392    pfam00057    pfam15494    pfam00089   
Domain families : Smart (EMBL)FRI (SM00063)  LDLa (SM00192)  SR (SM00202)  Tryp_SPc (SM00020)  
Conserved Domain (NCBI)CORIN
DMDM Disease mutations10699
Blocks (Seattle)CORIN
SuperfamilyQ9Y5Q5
Human Protein Atlas [tissue]ENSG00000145244-CORIN [tissue]
Peptide AtlasQ9Y5Q5
HPRD05573
IPIIPI00295138   IPI00965412   IPI00965120   IPI00966447   IPI00965984   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y5Q5
IntAct (EBI)Q9Y5Q5
FunCoupENSG00000145244
BioGRIDCORIN
STRING (EMBL)CORIN
ZODIACCORIN
Ontologies - Pathways
QuickGOQ9Y5Q5
Ontology : AmiGOregulation of systemic arterial blood pressure by atrial natriuretic peptide  regulation of systemic arterial blood pressure by atrial natriuretic peptide  serine-type endopeptidase activity  serine-type endopeptidase activity  extracellular region  plasma membrane  plasma membrane  female pregnancy  regulation of blood pressure  cell surface  actin cytoskeleton  integral component of membrane  peptide hormone processing  nuclear body  regulation of renal sodium excretion  regulation of cardiac conduction  
Ontology : EGO-EBIregulation of systemic arterial blood pressure by atrial natriuretic peptide  regulation of systemic arterial blood pressure by atrial natriuretic peptide  serine-type endopeptidase activity  serine-type endopeptidase activity  extracellular region  plasma membrane  plasma membrane  female pregnancy  regulation of blood pressure  cell surface  actin cytoskeleton  integral component of membrane  peptide hormone processing  nuclear body  regulation of renal sodium excretion  regulation of cardiac conduction  
Pathways : BIOCARTACorticosteroids and cardioprotection [Genes]   
NDEx NetworkCORIN
Atlas of Cancer Signalling NetworkCORIN
Wikipedia pathwaysCORIN
Orthology - Evolution
OrthoDB10699
GeneTree (enSembl)ENSG00000145244
Phylogenetic Trees/Animal Genes : TreeFamCORIN
HOVERGENQ9Y5Q5
HOGENOMQ9Y5Q5
Homologs : HomoloGeneCORIN
Homology/Alignments : Family Browser (UCSC)CORIN
Gene fusions - Rearrangements
Fusion: Tumor Portal CORIN
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCORIN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CORIN
dbVarCORIN
ClinVarCORIN
1000_GenomesCORIN 
Exome Variant ServerCORIN
ExAC (Exome Aggregation Consortium)ENSG00000145244
GNOMAD BrowserENSG00000145244
Genetic variants : HAPMAP10699
Genomic Variants (DGV)CORIN [DGVbeta]
DECIPHERCORIN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCORIN 
Mutations
ICGC Data PortalCORIN 
TCGA Data PortalCORIN 
Broad Tumor PortalCORIN
OASIS PortalCORIN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCORIN  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCORIN
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CORIN
DgiDB (Drug Gene Interaction Database)CORIN
DoCM (Curated mutations)CORIN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CORIN (select a term)
intoGenCORIN
Cancer3DCORIN(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605236    614595   
Orphanet20319   
MedgenCORIN
Genetic Testing Registry CORIN
NextProtQ9Y5Q5 [Medical]
TSGene10699
GENETestsCORIN
Target ValidationCORIN
Huge Navigator CORIN [HugePedia]
snp3D : Map Gene to Disease10699
BioCentury BCIQCORIN
ClinGenCORIN
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10699
Chemical/Pharm GKB GenePA134972424
Clinical trialCORIN
Miscellaneous
canSAR (ICR)CORIN (select the gene name)
Probes
Litterature
PubMed49 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCORIN
EVEXCORIN
GoPubMedCORIN
iHOPCORIN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 11:43:13 CET 2017

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