CORIN (corin, serine peptidase)

2014-11-01  

Identity

HGNC
LOCATION
4p12
LOCUSID
ALIAS
ATC2,CRN,Lrp4,PEE5,TMPRSS10
FUSION GENES

Other Information

Locus ID:

NCBI: 10699
MIM: 605236
HGNC: 19012
Ensembl: ENSG00000145244

Variants:

dbSNP: 10699
ClinVar: 10699
TCGA: ENSG00000145244
COSMIC: CORIN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145244ENST00000273857Q9Y5Q5
ENSG00000145244ENST00000502252J3KR88
ENSG00000145244ENST00000504584J3KR83
ENSG00000145244ENST00000505909J3KR90
ENSG00000145244ENST00000508498E7EQE7
ENSG00000145244ENST00000610355A0A087X1D5

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Muscle contractionREACTOMER-HSA-397014
Cardiac conductionREACTOMER-HSA-5576891
Physiological factorsREACTOMER-HSA-5578768

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
162169582005Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension.75
162169582005Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension.75
224375032012Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy.73
172968752007Corin I555(P568) allele is associated with enhanced cardiac hypertrophic response to increased systemic afterload.54
186699222008Corin variant associated with hypertension and cardiac hypertrophy exhibits impaired zymogen activation and natriuretic peptide processing activity.54
212168312011Decompensated heart failure is associated with reduced corin levels and decreased cleavage of pro-atrial natriuretic peptide.41
176605142007Role of glycosylation in corin zymogen activation.39
212889002011Ectodomain shedding and autocleavage of the cardiac membrane protease corin.37
118844162002Processing of pro-atrial natriuretic peptide by corin in cardiac myocytes.36

Citation

Dessen P

CORIN (corin, serine peptidase)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62031/corin