Atlas of Genetics and Cytogenetics in Oncology and Haematology

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COTL1 (coactosin like F-actin binding protein 1)

Identity

Alias (NCBI)CLP
HGNC (Hugo) COTL1
HGNC Alias symbCLP
HGNC Previous namecoactosin-like 1 (Dictyostelium)
 coactosin-like F-actin binding protein 1
LocusID (NCBI) 23406
Atlas_Id 46173
Location 16q24.1  [Link to chromosome band 16q24]
Location_base_pair Starts at 84565598 and ends at 84618078 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CHST6 (16q23.1) / COTL1 (16q24.1)CMIP (16q23.2) / COTL1 (16q24.1)COTL1 (16q24.1) / FAM65A (16q22.1)
COTL1 (16q24.1) / G6PC3 (17q21.31)COTL1 (16q24.1) / METTL7A (12q13.12)COTL1 (16q24.1) / TMEM232 (5q22.1)
FURIN (15q26.1) / COTL1 (16q24.1)USP10 (16q24.1) / COTL1 (16q24.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)COTL1   18304
Cards
Entrez_Gene (NCBI)COTL1  23406  coactosin like F-actin binding protein 1
AliasesCLP
GeneCards (Weizmann)COTL1
Ensembl hg19 (Hinxton)ENSG00000103187 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000103187 [Gene_View]  ENSG00000103187 [Sequence]  chr16:84565598-84618078 [Contig_View]  COTL1 [Vega]
ICGC DataPortalENSG00000103187
TCGA cBioPortalCOTL1
AceView (NCBI)COTL1
Genatlas (Paris)COTL1
WikiGenes23406
SOURCE (Princeton)COTL1
Genetics Home Reference (NIH)COTL1
Genomic and cartography
GoldenPath hg38 (UCSC)COTL1  -     chr16:84565598-84618078 -  16q24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)COTL1  -     16q24.1   [Description]    (hg19-Feb_2009)
GoldenPathCOTL1 - 16q24.1 [CytoView hg19]  COTL1 - 16q24.1 [CytoView hg38]
ImmunoBaseENSG00000103187
genome Data Viewer NCBICOTL1 [Mapview hg19]  
OMIM606748   
Gene and transcription
Genbank (Entrez)AK026033 AK093712 AK125645 AK127352 AK315675
RefSeq transcript (Entrez)NM_021149
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)COTL1
Alternative Splicing GalleryENSG00000103187
Gene ExpressionCOTL1 [ NCBI-GEO ]   COTL1 [ EBI - ARRAY_EXPRESS ]   COTL1 [ SEEK ]   COTL1 [ MEM ]
Gene Expression Viewer (FireBrowse)COTL1 [ Firebrowse - Broad ]
GenevisibleExpression of COTL1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23406
GTEX Portal (Tissue expression)COTL1
Human Protein AtlasENSG00000103187-COTL1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14019   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14019  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14019
Splice isoforms : SwissVarQ14019
PhosPhoSitePlusQ14019
Domaine pattern : Prosite (Expaxy)ADF_H (PS51263)   
Domains : Interpro (EBI)ADF-H    ADF-H/Gelsolin-like_dom_sf    CLP   
Domain families : Pfam (Sanger)Cofilin_ADF (PF00241)   
Domain families : Pfam (NCBI)pfam00241   
Domain families : Smart (EMBL)ADF (SM00102)  
Conserved Domain (NCBI)COTL1
DMDM Disease mutations23406
Blocks (Seattle)COTL1
PDB (RSDB)1T2L    1T3X    1T3Y    1TMW    1VFQ    1WNJ   
PDB Europe1T2L    1T3X    1T3Y    1TMW    1VFQ    1WNJ   
PDB (PDBSum)1T2L    1T3X    1T3Y    1TMW    1VFQ    1WNJ   
PDB (IMB)1T2L    1T3X    1T3Y    1TMW    1VFQ    1WNJ   
Structural Biology KnowledgeBase1T2L    1T3X    1T3Y    1TMW    1VFQ    1WNJ   
SCOP (Structural Classification of Proteins)1T2L    1T3X    1T3Y    1TMW    1VFQ    1WNJ   
CATH (Classification of proteins structures)1T2L    1T3X    1T3Y    1TMW    1VFQ    1WNJ   
SuperfamilyQ14019
Human Protein Atlas [tissue]ENSG00000103187-COTL1 [tissue]
Peptide AtlasQ14019
HPRD09482
IPIIPI00017704   IPI00921562   
Protein Interaction databases
DIP (DOE-UCLA)Q14019
IntAct (EBI)Q14019
FunCoupENSG00000103187
BioGRIDCOTL1
STRING (EMBL)COTL1
ZODIACCOTL1
Ontologies - Pathways
QuickGOQ14019
Ontology : AmiGOactin binding  protein binding  extracellular region  nucleus  cytosol  actin filament  plasma membrane  biological_process  enzyme binding  regulation of actin filament polymerization  cortical actin cytoskeleton  secretory granule lumen  neutrophil degranulation  defense response to fungus  actin filament binding  extracellular exosome  ficolin-1-rich granule lumen  
Ontology : EGO-EBIactin binding  protein binding  extracellular region  nucleus  cytosol  actin filament  plasma membrane  biological_process  enzyme binding  regulation of actin filament polymerization  cortical actin cytoskeleton  secretory granule lumen  neutrophil degranulation  defense response to fungus  actin filament binding  extracellular exosome  ficolin-1-rich granule lumen  
NDEx NetworkCOTL1
Atlas of Cancer Signalling NetworkCOTL1
Wikipedia pathwaysCOTL1
Orthology - Evolution
OrthoDB23406
GeneTree (enSembl)ENSG00000103187
Phylogenetic Trees/Animal Genes : TreeFamCOTL1
HOGENOMQ14019
Homologs : HomoloGeneCOTL1
Homology/Alignments : Family Browser (UCSC)COTL1
Gene fusions - Rearrangements
Fusion : QuiverCOTL1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCOTL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)COTL1
dbVarCOTL1
ClinVarCOTL1
MonarchCOTL1
1000_GenomesCOTL1 
Exome Variant ServerCOTL1
GNOMAD BrowserENSG00000103187
Varsome BrowserCOTL1
Genetic variants : HAPMAP23406
Genomic Variants (DGV)COTL1 [DGVbeta]
DECIPHERCOTL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCOTL1 
Mutations
ICGC Data PortalCOTL1 
TCGA Data PortalCOTL1 
Broad Tumor PortalCOTL1
OASIS PortalCOTL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCOTL1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCOTL1
Mutations and Diseases : HGMDCOTL1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch COTL1
DgiDB (Drug Gene Interaction Database)COTL1
DoCM (Curated mutations)COTL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)COTL1 (select a term)
intoGenCOTL1
Cancer3DCOTL1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606748   
Orphanet
DisGeNETCOTL1
MedgenCOTL1
Genetic Testing Registry COTL1
NextProtQ14019 [Medical]
TSGene23406
GENETestsCOTL1
Target ValidationCOTL1
Huge Navigator COTL1 [HugePedia]
snp3D : Map Gene to Disease23406
BioCentury BCIQCOTL1
ClinGenCOTL1
Clinical trials, drugs, therapy
Protein Interactions : CTD23406
Pharm GKB GenePA38522
Clinical trialCOTL1
Miscellaneous
canSAR (ICR)COTL1 (select the gene name)
HarmonizomeCOTL1
DataMed IndexCOTL1
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCOTL1
EVEXCOTL1
GoPubMedCOTL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 14 14:06:59 CEST 2020
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