Atlas of Genetics and Cytogenetics in Oncology and Haematology


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COTL1 (coactosin like F-actin binding protein 1)

Identity

Other namesCLP
HGNC (Hugo) COTL1
LocusID (NCBI) 23406
Atlas_Id 46173
Location 16q24.1
Location_base_pair Starts at 84599204 and ends at 84651702 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CHST6 (16q23.1) / COTL1 (16q24.1)CMIP (16q23.2) / COTL1 (16q24.1)COTL1 (16q24.1) / FAM65A (16q22.1)
COTL1 (16q24.1) / G6PC3 (17q21.31)COTL1 (16q24.1) / METTL7A (12q13.12)COTL1 (16q24.1) / TMEM232 (5q22.1)
FURIN (15q26.1) / COTL1 (16q24.1)USP10 (16q24.1) / COTL1 (16q24.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)COTL1   18304
Cards
Entrez_Gene (NCBI)COTL1  23406  coactosin like F-actin binding protein 1
GeneCards (Weizmann)COTL1
Ensembl hg19 (Hinxton)ENSG00000103187 [Gene_View]  chr16:84599204-84651702 [Contig_View]  COTL1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000103187 [Gene_View]  chr16:84599204-84651702 [Contig_View]  COTL1 [Vega]
ICGC DataPortalENSG00000103187
TCGA cBioPortalCOTL1
AceView (NCBI)COTL1
Genatlas (Paris)COTL1
WikiGenes23406
SOURCE (Princeton)COTL1
Genomic and cartography
GoldenPath hg19 (UCSC)COTL1  -     chr16:84599204-84651702 -  16q24.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)COTL1  -     16q24.1   [Description]    (hg38-Dec_2013)
EnsemblCOTL1 - 16q24.1 [CytoView hg19]  COTL1 - 16q24.1 [CytoView hg38]
Mapping of homologs : NCBICOTL1 [Mapview hg19]  COTL1 [Mapview hg38]
OMIM606748   
Gene and transcription
Genbank (Entrez)AK026033 AK093712 AK125645 AK127352 AK315675
RefSeq transcript (Entrez)NM_021149
RefSeq genomic (Entrez)NC_000016 NC_018927 NT_010498 NW_004929402
Consensus coding sequences : CCDS (NCBI)COTL1
Cluster EST : UnigeneHs.289092 [ NCBI ]
CGAP (NCI)Hs.289092
Alternative Splicing : Fast-db (Paris)GSHG0012033
Alternative Splicing GalleryENSG00000103187
Gene ExpressionCOTL1 [ NCBI-GEO ]   COTL1 [ EBI - ARRAY_EXPRESS ]   COTL1 [ SEEK ]   COTL1 [ MEM ]
Gene Expression Viewer (FireBrowse)COTL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)23406
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14019 (Uniprot)
NextProtQ14019  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14019
Splice isoforms : SwissVarQ14019 (Swissvar)
PhosPhoSitePlusQ14019
Domaine pattern : Prosite (Expaxy)ADF_H (PS51263)   
Domains : Interpro (EBI)ADF-H    ADF-H/Gelsolin-like_dom   
Domain families : Pfam (Sanger)Cofilin_ADF (PF00241)   
Domain families : Pfam (NCBI)pfam00241   
Domain families : Smart (EMBL)ADF (SM00102)  
DMDM Disease mutations23406
Blocks (Seattle)COTL1
PDB (SRS)1T2L    1T3X    1T3Y    1TMW    1VFQ    1WNJ   
PDB (PDBSum)1T2L    1T3X    1T3Y    1TMW    1VFQ    1WNJ   
PDB (IMB)1T2L    1T3X    1T3Y    1TMW    1VFQ    1WNJ   
PDB (RSDB)1T2L    1T3X    1T3Y    1TMW    1VFQ    1WNJ   
Structural Biology KnowledgeBase1T2L    1T3X    1T3Y    1TMW    1VFQ    1WNJ   
SCOP (Structural Classification of Proteins)1T2L    1T3X    1T3Y    1TMW    1VFQ    1WNJ   
CATH (Classification of proteins structures)1T2L    1T3X    1T3Y    1TMW    1VFQ    1WNJ   
SuperfamilyQ14019
Human Protein AtlasENSG00000103187
Peptide AtlasQ14019
HPRD09482
IPIIPI00017704   IPI00921562   
Protein Interaction databases
DIP (DOE-UCLA)Q14019
IntAct (EBI)Q14019
FunCoupENSG00000103187
BioGRIDCOTL1
STRING (EMBL)COTL1
ZODIACCOTL1
Ontologies - Pathways
QuickGOQ14019
Ontology : AmiGOactin binding  protein binding  nucleus  cytoplasm  cytoskeleton  biological_process  enzyme binding  defense response to fungus  extracellular exosome  
Ontology : EGO-EBIactin binding  protein binding  nucleus  cytoplasm  cytoskeleton  biological_process  enzyme binding  defense response to fungus  extracellular exosome  
NDEx Network
Atlas of Cancer Signalling NetworkCOTL1
Wikipedia pathwaysCOTL1
Orthology - Evolution
OrthoDB23406
GeneTree (enSembl)ENSG00000103187
Phylogenetic Trees/Animal Genes : TreeFamCOTL1
Homologs : HomoloGeneCOTL1
Homology/Alignments : Family Browser (UCSC)COTL1
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerCOTL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)COTL1
dbVarCOTL1
ClinVarCOTL1
1000_GenomesCOTL1 
Exome Variant ServerCOTL1
ExAC (Exome Aggregation Consortium)COTL1 (select the gene name)
SNP (GeneSNP Utah)COTL1
SNP : HGBaseCOTL1
Genetic variants : HAPMAPCOTL1
Genomic Variants (DGV)COTL1 [DGVbeta]
Mutations
ICGC Data PortalCOTL1 
TCGA Data PortalCOTL1 
Broad Tumor PortalCOTL1
OASIS PortalCOTL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCOTL1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch COTL1
DgiDB (Drug Gene Interaction Database)COTL1
DoCM (Curated mutations)COTL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)COTL1 (select a term)
intoGenCOTL1
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)16:84599204-84651702
CONAN: Copy Number AnalysisCOTL1 
Mutations and Diseases : HGMDCOTL1
OMIM606748   
MedgenCOTL1
Genetic Testing Registry COTL1
NextProtQ14019 [Medical]
TSGene23406
GENETestsCOTL1
Huge Navigator COTL1 [HugePedia]  COTL1 [HugeCancerGEM]
snp3D : Map Gene to Disease23406
BioCentury BCIQCOTL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23406
Chemical/Pharm GKB GenePA38522
Clinical trialCOTL1
Miscellaneous
canSAR (ICR)COTL1 (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCOTL1
GoPubMedCOTL1
iHOPCOTL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Apr 16 17:40:54 CEST 2016

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