COTL1 (coactosin like F-actin binding protein 1)

2007-02-01  

Identity

HGNC
COTL1
LOCATION
16q24.1
LOCUSID
23406
ALIAS
CLP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23406
MIM: 606748
HGNC: 18304
Ensembl: ENSG00000103187

Variants:

dbSNP: 23406
ClinVar: 23406
TCGA: ENSG00000103187
COSMIC: COTL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103187ENST00000262428Q14019
ENSG00000103187ENST00000262428A0A384MTY2
ENSG00000103187ENST00000564057H3BT58
ENSG00000103187ENST00000567786A0A087WWC7

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
169241042006Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production.25
198076932009Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102.16
250342522014Roles of coactosin-like protein (CLP) and 5-lipoxygenase-activating protein (FLAP) in cellular leukotriene biosynthesis.14
118706272002Cellular and humoral immune responses to a human pancreatic cancer antigen, coactosin-like protein, originally defined by the SEREX method.12
244547962014Coactosin-like 1 antagonizes cofilin to promote lamellipodial protrusion at the immune synapse.11
278934172017Genetic and epigenetic silencing of mircoRNA-506-3p enhances COTL1 oncogene expression to foster non-small lung cancer progression.11
170701222006Binding model of human coactosin-like protein with filament actin revealed by mutagenesis.7
193077562009Polymorphisms of COTL1 gene identified by proteomic approach and their association with autoimmune disorders.7
193077562009Polymorphisms of COTL1 gene identified by proteomic approach and their association with autoimmune disorders.7
210470532011Proteomic analysis of human small cell lung cancer tissues: up-regulation of coactosin-like protein-1.7

Citation

Dessen P

COTL1 (coactosin like F-actin binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46173/cotl1