Atlas of Genetics and Cytogenetics in Oncology and Haematology


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COX4I1 (cytochrome c oxidase subunit 4I1)

Identity

Alias (NCBI)COX IV-1
COX4
COX4-1
COXIV
COXIV-1
MC4DN16
HGNC (Hugo) COX4I1
HGNC Alias symbCOX4-1
HGNC Previous nameCOX4
HGNC Previous namecytochrome c oxidase subunit IV
 cytochrome c oxidase subunit IV isoform 1
LocusID (NCBI) 1327
Atlas_Id 47235
Location 16q24.1  [Link to chromosome band 16q24]
Location_base_pair Starts at 85799695 and ends at 85807068 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
COX4I1 (16q24.1) / NOP16 (5q35.2)COX4I1 (16q24.1) / TOMM22 (22q13.1)KMT5B (11q13.2) / COX4I1 (16q24.1)
WHSC1L1 (8p11.23) / COX4I1 (16q24.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)COX4I1   2265
Cards
Entrez_Gene (NCBI)COX4I1    cytochrome c oxidase subunit 4I1
AliasesCOX; COX4; COX4-1; COXIV; 
COXIV-1; MC4DN16
GeneCards (Weizmann)COX4I1
Ensembl hg19 (Hinxton)ENSG00000131143 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000131143 [Gene_View]  ENSG00000131143 [Sequence]  chr16:85799695-85807068 [Contig_View]  COX4I1 [Vega]
ICGC DataPortalENSG00000131143
TCGA cBioPortalCOX4I1
AceView (NCBI)COX4I1
Genatlas (Paris)COX4I1
SOURCE (Princeton)COX4I1
Genetics Home Reference (NIH)COX4I1
Genomic and cartography
GoldenPath hg38 (UCSC)COX4I1  -     chr16:85799695-85807068 +  16q24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)COX4I1  -     16q24.1   [Description]    (hg19-Feb_2009)
GoldenPathCOX4I1 - 16q24.1 [CytoView hg19]  COX4I1 - 16q24.1 [CytoView hg38]
ImmunoBaseENSG00000131143
Genome Data Viewer NCBICOX4I1 [Mapview hg19]  
OMIM123864   619060   
Gene and transcription
Genbank (Entrez)AK027136 AK311847 BC008704 BC021236 BC039013
RefSeq transcript (Entrez)NM_001318786 NM_001318788 NM_001318794 NM_001318797 NM_001318802 NM_001861
Consensus coding sequences : CCDS (NCBI)COX4I1
Gene ExpressionCOX4I1 [ NCBI-GEO ]   COX4I1 [ EBI - ARRAY_EXPRESS ]   COX4I1 [ SEEK ]   COX4I1 [ MEM ]
Gene Expression Viewer (FireBrowse)COX4I1 [ Firebrowse - Broad ]
GenevisibleExpression of COX4I1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1327
GTEX Portal (Tissue expression)COX4I1
Human Protein AtlasENSG00000131143-COX4I1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP13073   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP13073  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP13073
PhosPhoSitePlusP13073
Domains : Interpro (EBI)Cyt_c_oxidase_su4    Cyt_c_oxidase_su4_fam    Cyt_c_oxidase_su4_sf   
Domain families : Pfam (Sanger)COX4 (PF02936)   
Domain families : Pfam (NCBI)pfam02936   
Conserved Domain (NCBI)COX4I1
PDB (RSDB)5Z62   
PDB Europe5Z62   
PDB (PDBSum)5Z62   
PDB (IMB)5Z62   
Structural Biology KnowledgeBase5Z62   
SCOP (Structural Classification of Proteins)5Z62   
CATH (Classification of proteins structures)5Z62   
SuperfamilyP13073
AlphaFold pdb e-kbP13073   
Human Protein Atlas [tissue]ENSG00000131143-COX4I1 [tissue]
HPRD00466
Protein Interaction databases
DIP (DOE-UCLA)P13073
IntAct (EBI)P13073
BioGRIDCOX4I1
STRING (EMBL)COX4I1
ZODIACCOX4I1
Ontologies - Pathways
QuickGOP13073
Ontology : AmiGOcytochrome-c oxidase activity  protein binding  nucleoplasm  mitochondrion  mitochondrion  mitochondrial inner membrane  mitochondrial inner membrane  mitochondrial respiratory chain complex IV  mitochondrial respiratory chain complex IV  cytosol  generation of precursor metabolites and energy  mitochondrial electron transport, cytochrome c to oxygen  mitochondrial electron transport, cytochrome c to oxygen  response to nutrient  membrane  integral component of membrane  proton transmembrane transport  
Ontology : EGO-EBIcytochrome-c oxidase activity  protein binding  nucleoplasm  mitochondrion  mitochondrion  mitochondrial inner membrane  mitochondrial inner membrane  mitochondrial respiratory chain complex IV  mitochondrial respiratory chain complex IV  cytosol  generation of precursor metabolites and energy  mitochondrial electron transport, cytochrome c to oxygen  mitochondrial electron transport, cytochrome c to oxygen  response to nutrient  membrane  integral component of membrane  proton transmembrane transport  
Pathways : KEGGOxidative phosphorylation    Cardiac muscle contraction    Non-alcoholic fatty liver disease (NAFLD)    Alzheimer's disease    Parkinson's disease    Huntington's disease   
NDEx NetworkCOX4I1
Atlas of Cancer Signalling NetworkCOX4I1
Wikipedia pathwaysCOX4I1
Orthology - Evolution
OrthoDB1327
GeneTree (enSembl)ENSG00000131143
Phylogenetic Trees/Animal Genes : TreeFamCOX4I1
Homologs : HomoloGeneCOX4I1
Homology/Alignments : Family Browser (UCSC)COX4I1
Gene fusions - Rearrangements
Fusion : QuiverCOX4I1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCOX4I1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)COX4I1
dbVarCOX4I1
ClinVarCOX4I1
MonarchCOX4I1
1000_GenomesCOX4I1 
Exome Variant ServerCOX4I1
GNOMAD BrowserENSG00000131143
Varsome BrowserCOX4I1
ACMGCOX4I1 variants
VarityP13073
Genomic Variants (DGV)COX4I1 [DGVbeta]
DECIPHERCOX4I1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCOX4I1 
Mutations
ICGC Data PortalCOX4I1 
TCGA Data PortalCOX4I1 
Broad Tumor PortalCOX4I1
OASIS PortalCOX4I1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCOX4I1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCOX4I1
Mutations and Diseases : HGMDCOX4I1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCOX4I1
DgiDB (Drug Gene Interaction Database)COX4I1
DoCM (Curated mutations)COX4I1
CIViC (Clinical Interpretations of Variants in Cancer)COX4I1
Cancer3DCOX4I1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM123864    619060   
Orphanet
DisGeNETCOX4I1
MedgenCOX4I1
Genetic Testing Registry COX4I1
NextProtP13073 [Medical]
GENETestsCOX4I1
Target ValidationCOX4I1
Huge Navigator COX4I1 [HugePedia]
ClinGenCOX4I1
Clinical trials, drugs, therapy
MyCancerGenomeCOX4I1
Protein Interactions : CTDCOX4I1
Pharm GKB GenePA26781
PharosP13073
Clinical trialCOX4I1
Miscellaneous
canSAR (ICR)COX4I1
HarmonizomeCOX4I1
DataMed IndexCOX4I1
Probes
Litterature
PubMed91 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCOX4I1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:04:56 CEST 2021

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