Atlas of Genetics and Cytogenetics in Oncology and Haematology


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COX8A (cytochrome c oxidase subunit 8A)

Identity

Alias_namesCOX8
cytochrome c oxidase subunit VIII
cytochrome c oxidase subunit VIIIA (ubiquitous)
Alias_symbol (synonym)COX8-2
COX8L
VIII-L
COX
VIII
Other alias
HGNC (Hugo) COX8A
LocusID (NCBI) 1351
Atlas_Id 47192
Location 11q13.1  [Link to chromosome band 11q13]
Location_base_pair Starts at 63974607 and ends at 63976543 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
COX8A (11q13.1) / AGFG1 (2q36.3)COX8A (11q13.1) / SHMT2 (12q13.3)OTUB1 (11q13.1) / COX8A (11q13.1)
RILPL1 (12q24.31) / COX8A (11q13.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)COX8A   2294
Cards
Entrez_Gene (NCBI)COX8A  1351  cytochrome c oxidase subunit 8A
AliasesCOX; COX8; COX8-2; COX8L; 
VIII; VIII-L
GeneCards (Weizmann)COX8A
Ensembl hg19 (Hinxton)ENSG00000176340 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000176340 [Gene_View]  chr11:63974607-63976543 [Contig_View]  COX8A [Vega]
ICGC DataPortalENSG00000176340
TCGA cBioPortalCOX8A
AceView (NCBI)COX8A
Genatlas (Paris)COX8A
WikiGenes1351
SOURCE (Princeton)COX8A
Genetics Home Reference (NIH)COX8A
Genomic and cartography
GoldenPath hg38 (UCSC)COX8A  -     chr11:63974607-63976543 +  11q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)COX8A  -     11q13.1   [Description]    (hg19-Feb_2009)
EnsemblCOX8A - 11q13.1 [CytoView hg19]  COX8A - 11q13.1 [CytoView hg38]
Mapping of homologs : NCBICOX8A [Mapview hg19]  COX8A [Mapview hg38]
OMIM123870   
Gene and transcription
Genbank (Entrez)AK311934 BC000501 BC063025 BT009803 CR407687
RefSeq transcript (Entrez)NM_004074
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)COX8A
Cluster EST : UnigeneHs.743989 [ NCBI ]
CGAP (NCI)Hs.743989
Alternative Splicing GalleryENSG00000176340
Gene ExpressionCOX8A [ NCBI-GEO ]   COX8A [ EBI - ARRAY_EXPRESS ]   COX8A [ SEEK ]   COX8A [ MEM ]
Gene Expression Viewer (FireBrowse)COX8A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1351
GTEX Portal (Tissue expression)COX8A
Protein : pattern, domain, 3D structure
UniProt/SwissProtP10176   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP10176  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP10176
Splice isoforms : SwissVarP10176
PhosPhoSitePlusP10176
Domains : Interpro (EBI)Cyt_c_oxidase_su8    Cyt_c_oxidase_su8/PSI_RC_su9   
Domain families : Pfam (Sanger)COX8 (PF02285)   
Domain families : Pfam (NCBI)pfam02285   
Conserved Domain (NCBI)COX8A
DMDM Disease mutations1351
Blocks (Seattle)COX8A
SuperfamilyP10176
Human Protein AtlasENSG00000176340
Peptide AtlasP10176
HPRD00468
IPIIPI00019505   
Protein Interaction databases
DIP (DOE-UCLA)P10176
IntAct (EBI)P10176
FunCoupENSG00000176340
BioGRIDCOX8A
STRING (EMBL)COX8A
ZODIACCOX8A
Ontologies - Pathways
QuickGOP10176
Ontology : AmiGOcytochrome-c oxidase activity  protein binding  mitochondrial inner membrane  mitochondrial respiratory chain complex IV  generation of precursor metabolites and energy  mitochondrial electron transport, cytochrome c to oxygen  mitochondrial electron transport, cytochrome c to oxygen  integral component of membrane  hydrogen ion transmembrane transport  
Ontology : EGO-EBIcytochrome-c oxidase activity  protein binding  mitochondrial inner membrane  mitochondrial respiratory chain complex IV  generation of precursor metabolites and energy  mitochondrial electron transport, cytochrome c to oxygen  mitochondrial electron transport, cytochrome c to oxygen  integral component of membrane  hydrogen ion transmembrane transport  
Pathways : KEGGOxidative phosphorylation    Cardiac muscle contraction    Non-alcoholic fatty liver disease (NAFLD)    Alzheimer's disease    Parkinson's disease    Huntington's disease   
NDEx NetworkCOX8A
Atlas of Cancer Signalling NetworkCOX8A
Wikipedia pathwaysCOX8A
Orthology - Evolution
OrthoDB1351
GeneTree (enSembl)ENSG00000176340
Phylogenetic Trees/Animal Genes : TreeFamCOX8A
HOVERGENP10176
HOGENOMP10176
Homologs : HomoloGeneCOX8A
Homology/Alignments : Family Browser (UCSC)COX8A
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCOX8A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)COX8A
dbVarCOX8A
ClinVarCOX8A
1000_GenomesCOX8A 
Exome Variant ServerCOX8A
ExAC (Exome Aggregation Consortium)COX8A (select the gene name)
Genetic variants : HAPMAP1351
Genomic Variants (DGV)COX8A [DGVbeta]
DECIPHERCOX8A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCOX8A 
Mutations
ICGC Data PortalCOX8A 
TCGA Data PortalCOX8A 
Broad Tumor PortalCOX8A
OASIS PortalCOX8A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCOX8A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCOX8A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch COX8A
DgiDB (Drug Gene Interaction Database)COX8A
DoCM (Curated mutations)COX8A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)COX8A (select a term)
intoGenCOX8A
Cancer3DCOX8A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM123870   
Orphanet19799   
MedgenCOX8A
Genetic Testing Registry COX8A
NextProtP10176 [Medical]
TSGene1351
GENETestsCOX8A
Target ValidationCOX8A
Huge Navigator COX8A [HugePedia]
snp3D : Map Gene to Disease1351
BioCentury BCIQCOX8A
ClinGenCOX8A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1351
Chemical/Pharm GKB GenePA26814
Clinical trialCOX8A
Miscellaneous
canSAR (ICR)COX8A (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCOX8A
EVEXCOX8A
GoPubMedCOX8A
iHOPCOX8A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:29:21 CEST 2017

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