CP (ceruloplasmin)

2007-02-01  

Identity

HGNC
CP
LOCATION
3q24
LOCUSID
1356
ALIAS
CP-2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1356
MIM: 117700
HGNC: 2295
Ensembl: ENSG00000047457

Variants:

dbSNP: 1356
ClinVar: 1356
TCGA: ENSG00000047457
COSMIC: CP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000047457ENST00000264613P00450
ENSG00000047457ENST00000455472D6RE86
ENSG00000047457ENST00000479771H7C5N5
ENSG00000047457ENST00000481169E9PFZ2
ENSG00000047457ENST00000494544H7C5R1

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Porphyrin and chlorophyll metabolismKEGGko00860
Porphyrin and chlorophyll metabolismKEGGhsa00860
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Metal ion SLC transportersREACTOMER-HSA-425410
Iron uptake and transportREACTOMER-HSA-917937
FerroptosisKEGGko04216
FerroptosisKEGGhsa04216

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
157412202005Copper-dependent activation of hypoxia-inducible factor (HIF)-1: implications for ceruloplasmin regulation.61
211095022011Decreased serum ceruloplasmin levels characteristically aggravate nigral iron deposition in Parkinson's disease.38
183070392008Free copper, ferroxidase and SOD1 activities, lipid peroxidation and NO(x) content in the CSF. A different marker profile in four neurodegenerative diseases.37
245331652014Glial cell ceruloplasmin and hepcidin differentially regulate iron efflux from brain microvascular endothelial cells.31
233062002013Ceruloplasmin is an endogenous inhibitor of myeloperoxidase.30
123516282002Mechanisms of copper incorporation into human ceruloplasmin.29
127081322003Copper and ceruloplasmin status in serum of prostate and colon cancer patients.28
129529742003Role of ceruloplasmin in macrophage iron efflux during hypoxia.28
176013502007A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.27
206553812010Biological effects of mutant ceruloplasmin on hepcidin-mediated internalization of ferroportin.27

Citation

Dessen P

CP (ceruloplasmin)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45927/cp