CPA2 (carboxypeptidase A2)

2014-11-01  

Identity

HGNC
LOCATION
7q32.2
LOCUSID
ALIAS
-

Other Information

Locus ID:

NCBI: 1358
MIM: 600688
HGNC: 2297
Ensembl: ENSG00000158516

Variants:

dbSNP: 1358
ClinVar: 1358
TCGA: ENSG00000158516
COSMIC: CPA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000158516ENST00000222481P48052
ENSG00000158516ENST00000416698J3QT58

Expression (GTEx)

0
5000
10000
15000

Pathways

PathwaySourceExternal ID
Pancreatic secretionKEGGko04972
Pancreatic secretionKEGGhsa04972
Protein digestion and absorptionKEGGko04974
Protein digestion and absorptionKEGGhsa04974

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA445220PancreatitisDiseaseClinicalAnnotationassociatedPD27114598
PA446155Precursor Cell Lymphoblastic Leukemia-LymphomaDiseaseClinicalAnnotationassociatedPD27114598
PA448492asparaginaseChemicalClinicalAnnotationassociatedPD27114598

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
194016822010High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility.52
171969782007High-resolution structural and thermodynamic analysis of extreme stabilization of human procarboxypeptidase by computational protein design.41
210980232011Chymotrypsin C is a co-activator of human pancreatic procarboxypeptidases A1 and A2.16
117437342001Changes in zinc ligation promote remodeling of the active site in the zinc hydrolase superfamily.9
273584032016Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2.8
263165922015Variants in pancreatic carboxypeptidase genes CPA2 and CPB1 are not associated with chronic pancreatitis.5
198175002009Influence of aggregation propensity and stability on amyloid fibril formation as studied by Fourier transform infrared spectroscopy and two-dimensional COS analysis.4
125388932003NMR solution structure of the activation domain of human procarboxypeptidase A2.1
261150972015Probing the Residual Structure of the Low Populated Denatured State of ADA2h under Folding Conditions by Relaxation Dispersion Nuclear Magnetic Resonance Spectroscopy.0

Citation

Dessen P

CPA2 (carboxypeptidase A2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62044/cpa2