CPA4 (carboxypeptidase A4)

2009-05-01  

Identity

HGNC
CPA4
LOCATION
7q32.2
LOCUSID
51200
ALIAS
CPA3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51200
MIM: 607635
HGNC: 15740
Ensembl: ENSG00000128510

Variants:

dbSNP: 51200
ClinVar: 51200
TCGA: ENSG00000128510
COSMIC: CPA4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128510ENST00000222482Q9UI42
ENSG00000128510ENST00000222482A4D1M3
ENSG00000128510ENST00000445470Q9UI42
ENSG00000128510ENST00000473956C9J6N7
ENSG00000128510ENST00000486598C9J7D6
ENSG00000128510ENST00000492072C9J3P4
ENSG00000128510ENST00000493259B7Z5J4

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
203855632010Characterization of the substrate specificity of human carboxypeptidase A4 and implications for a role in extracellular peptide processing.24
125523182003The novel imprinted carboxypeptidase A4 gene ( CPA4) in the 7q32 imprinting domain.19
192457162009Carboxypeptidase 4 gene variants and early-onset intermediate-to-high risk prostate cancer.18
192457162009Carboxypeptidase 4 gene variants and early-onset intermediate-to-high risk prostate cancer.18
222946942012Crystal structure of novel metallocarboxypeptidase inhibitor from marine mollusk Nerita versicolor in complex with human carboxypeptidase A4.7
160918432005Detailed molecular comparison between the inhibition mode of A/B-type carboxypeptidases in the zymogen state and by the endogenous inhibitor latexin.6
277809212016Serum carboxypeptidaseA4 levels predict liver metastasis in colorectal carcinoma.6
282090922016Fibroblast growth factor-1 (FGF-1) promotes adipogenesis by downregulation of carboxypeptidase A4 (CPA4) - a negative regulator of adipogenesis implicated in the modulation of local and systemic insulin sensitivity.6
237468052013A noncanonical mechanism of carboxypeptidase inhibition revealed by the crystal structure of the Tri-Kunitz SmCI in complex with human CPA4.3
312798842019Carboxypeptidase A4 promotes cell growth via activating STAT3 and ERK signaling pathways and predicts a poor prognosis in colorectal cancer.3

Citation

Dessen P

CPA4 (carboxypeptidase A4)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50869/cpa4